Mucinous Eccrine Adenocarcinoma of the Periocular Region

Abstract

Mucinous eccrine adenocarcinoma is a rare ocular adnexal neoplasm that can involve the eyelid and periocular skin, can be locally invasive, and has a high risk of local recurrence despite Mohs surgery.

Primary Mucinous Carcinoma of the Skin with Orbital Invasion

“…In reviewing 14 primary mucinous carcinoma treated since 1988 either with Mohs surgery or frozen section control of the margins, Papalas [9] identified a lower recurrence rate (7%) than previously reported. However, recurences can still occur despite a successful Mohs surgery with clear margins [10]. In our situation, the presence of positive deep orbital margins despite a wide excision prompted the need for an exenteration.…”

Mucinous Eccrine Carcinoma

“…8 The differential diagnosis is diverse, including both benign entities such as cutaneous cyst, neuroma, or lipoma and malignant tumors such as sebaceous cell carcinoma, cystic basal cell carcinoma, squamous cell carcinoma, melanoma, and metastatic adenocarcinoma. 6 …”

“…6,7,17 Thirty percent of recurrences occur in the periorbital skin. 2,3 Other reported extension sites include: skeletal muscle, periosteum, bone, sinuses, lymphatic invasion, and perineural tissue.…”

“…2,5-7 Fewer than 5 cases of death have been reported, associated with multiple tumor recurrences and widespread metastatic disease. 6 The clinical appearance of MEC is highly varied. Most commonly, it appears as a solid, slow-growing nodule, cyst, or ulcerative lesion.…”

Mucinous eccrine adenocarcinoma of the eyelid: report of 6 cases

“…There is controversy regarding whether mucinous eccrine carcinoma arrises in a sweat gland or apocrine gland 3. This tumor has been described to arise in the eyelid, mostly in individual case reports 4–9.…”