Mucinous tubular and spindle cell carcinoma of kidney and problems in diagnosis

Sarsık, Banu; Şimşir, Adnan; Karaarslan, Serap; Şen, Sait

doi:10.5146/tjpath.2011.01059

Cited by 13 publications

(14 citation statements)

References 28 publications

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“…Immunohistochemical assay demonstrated that the tumor cells of MTSC and sPRCC were positive for AMACR, CK, CK7, CK19, EMA, HMWK, E-cadherin, vimentin and Ki - 67 index was <5%. These results were similar to the previous studies [ 7 - 10 , 13 ]. Whereas some differences were observed such as psammoma bodies was only seen in sPRCC (case 3) and two cases of MTSC were negative for CD10 and RCC.…”

Section: Discussionsupporting

confidence: 93%

Mucinous tubular and spindle cell carcinoma and solid variant papillary renal cell carcinoma: a clinicopathologic comparative analysis of four cases with similar molecular genetics datum

Zhang

Xiang

et al. 2014

Diagn Pathol

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Mucinous tubular and spindle cell carcinoma (MTSC) was first recognized as a specific entity in the World Health Organization 2004 classification. The “classic” tumor presentation includes an extracellular blue-gray mucinous/myxoid matrix accompanying the typical tubular and spindle cell epithelial components. Tubules are lined by cuboidal to columnar cells with bland nuclei, central small to medium sized nucleoli, and few to no mitoses. By expanding the histologic spectrum, a number of studies highlighted the distinction between MTSC and solid variant of papillary renal cell carcinoma (sPRCC), although controversy still exists. Here, we evaluated two cases of MTSC and compared two cases of sPRCC by light microscopy, special staining, immunohistochemical staining and fluorescence in situ hybridization (FISH). We found that morphologic and immunophenotyping features showed more overlap between MTSC and sPRCC. In addition, gains of chromosomes 7 and 17 and loss of Y, which are characteristic of PRCC, were observed in two cases of sPRCC and one case of MTSC, suggesting that MTSC is similar to sPRCC or may be a subtype of PRCC.Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_194

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Section: Discussionsupporting

confidence: 93%

Mucinous tubular and spindle cell carcinoma and solid variant papillary renal cell carcinoma: a clinicopathologic comparative analysis of four cases with similar molecular genetics datum

Zhang

Xiang

et al. 2014

Diagn Pathol

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“…Typically, there is a female predilection of 2:1 to 4:1 in reported series [2,[8][9][10][11]. In several series, nearly all the patients are female [12]. Patients present at a wide range of ages, with a mean age in the sixth decade [2,8,9,11].…”

Section: Introductionmentioning

confidence: 99%

Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: a detailed study of radiological, pathological and clinical outcomes

et al. 2015

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ObjectiveTo characterise the clinical, radiological and histological features of mucinous tubular and spindle cell carcinoma (MTSCC), as well as oncological outcomes. Patients and methodsThis is a single institution retrospective analysis of all patients with MTSCC from 2002 to 2011. Patients were excluded if MTSCC could not be confirmed on pathology re-review (four patients). Clinical characteristics, pathology, imaging, and outcomes were reviewed for the 19 included patients. ResultsThe median (range) age at diagnosis was 59 (17-71) years with a female predominance (78.9%). On contrast-enhanced computed tomography, MTSCC enhanced less than the cortex during the corticomedullary phase. The mean (range) tumour attenuation was 36 (24-48), 67 (41-133), 89 (49-152), and 76 (52-106) Hounsfield units in the pre-contrast, corticomedullary, nephrographic and excretory phases, respectively. In all, 16 patients were treated with partial (five patients) or radical nephrectomy (11) for pT1 (62.5%), pT2 (31.3%), and pT3a disease (6.3%). One patient underwent active surveillance. Of three patients (13.0%) managed with energy ablation, there was one recurrence that was treated with salvage surgery. One patient (5.3%) had metastatic disease at diagnosis and died from disease 64.7 months later. A patient with a pT2bN0M0 MTSCC with sarcomatoid dedifferentiation developed bone metastases 9.5 months after diagnosis and was alive at 19.0 months. The remainder were free of recurrence or progression. ConclusionMTSCC is a rare renal cell carcinoma (RCC) variant. In this largest series to date, MTSCC presented at a broad range of ages and displayed a female predilection. Imaging and pathological features of MTSCC display some overlap with papillary RCC. MTSCC is associated with excellent outcomes overall, but is not universally indolent.

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“…Also, in a comparative study of 27 cases of MTSCC and 20 cases of papillary renal cell carcinoma, the two type of tumors exhibit similar expression of AMACR (93% versus 95%), CK7 (81% versus 65%), EMA (95% versus 88%), high molecular weight cytokeratin (HMWK) (15% versus 15%), and c-kit (5% versus 18%), with CD10 being the only marker that showed a significant difference of expression (15% versus 80%) [10]. A more recent, similar, comparative research between MTSCC and papillary renal cell carcinoma (9, respectively 10 cases) confirmed the importance of CD10 in the differential diagnosis of the two entities [32]. Curiously, MTSCC also could present positive expression of neuroendocrine markers (neuron-specific enolase, chromogranin, and synaptophysin), of still uncertain signification [9,33].…”

Section: Discussionmentioning

confidence: 92%

A rare type of renal tumor – mucinous tubular and spindle cell carcinoma

Dima¹,

Aignătoaiei²,

Căruntu³

et al. 2015

Arch Clin Cases

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Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney, a rare renal cell carcinoma, is a low grade malignant tumor with histogenesis still under debate. We report the case of a 60-years-old female, asymptomatic, with no significant personal or family history, diagnosed on routine ultrasound examination with a unilateral non-homogenous mass in the right kidney. On gross examination the tumor was solid, well circumscribed, and limited to the kidney parenchyma. Microscopically, the tumor was composed from eosinophilic small cuboidal cell arranged in small, tightly packed, parallel tubular structures, myxoid stroma and mucinous areas (PAS and Alcian Blue positive). Therefore, the differential diagnosis between MTSCC and papillary renal cell carcinoma was compulsory. The immunohistochemistry assays confirmed MTSCC as the final diagnosis, based on the intense positive reaction for CK7 and negative reaction for CD10. The present report aimed to highlight the pathological characteristics of this rare subtype of renal cell tumors and to point out the differential diagnosis -particularly with the papillary renal cell carcinoma, given the different prognosis and therapeutic approach of these two entities.

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Mucinous tubular and spindle cell carcinoma of kidney and problems in diagnosis

Cited by 13 publications

References 28 publications

Mucinous tubular and spindle cell carcinoma and solid variant papillary renal cell carcinoma: a clinicopathologic comparative analysis of four cases with similar molecular genetics datum

Mucinous tubular and spindle cell carcinoma and solid variant papillary renal cell carcinoma: a clinicopathologic comparative analysis of four cases with similar molecular genetics datum

Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: a detailed study of radiological, pathological and clinical outcomes

A rare type of renal tumor – mucinous tubular and spindle cell carcinoma

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