2013
DOI: 10.1038/nrgastro.2013.120
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Mucins in pancreatic cancer and its microenvironment

Abstract: Pancreatic cancer remains a lethal malignancy with poor prognosis owing to therapeutic resistance, frequent recurrence and the absence of treatment strategies that specifically target the tumour and its supporting stroma. Deregulated cell-surface proteins drive neoplastic transformations and are envisioned to mediate crosstalk between the tumour and its microenvironment. Emerging studies have elaborated on the role of mucins in diverse biological functions, including enhanced tumorigenicity, invasiveness, meta… Show more

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Cited by 250 publications
(293 citation statements)
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References 133 publications
(135 reference statements)
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“…Some have been studied as biomarkers or targeted for pancreatic cancer treatment. Clinical studies suggest a correlation between the overexpression of mucins and pancreatic cancer (10)(11)(12)(13), and have demonstrated a link between the aberrant expression and differential overexpression of mucin glycoproteins and the initiation, progression, and poor prognosis of the disease (14-16, 19, 30). However, little advancement has been made in this area.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Some have been studied as biomarkers or targeted for pancreatic cancer treatment. Clinical studies suggest a correlation between the overexpression of mucins and pancreatic cancer (10)(11)(12)(13), and have demonstrated a link between the aberrant expression and differential overexpression of mucin glycoproteins and the initiation, progression, and poor prognosis of the disease (14-16, 19, 30). However, little advancement has been made in this area.…”
Section: Discussionmentioning
confidence: 99%
“…The mucins may prevent drugs from accessing their sites of action. The expression of several mucins, including MUC1, MUC4, MUC5AC, and MUC16, is highly upregulated in pancreatic ductal adenocarcinoma (PDAC), pancreatic intraepithelial neoplasia (PanIN), intrapapillary mucinous neoplasms, and mucinous cystic neoplasms from patients with pancreatic cancer (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The extent to which the dense mucin mesh influences the antiproliferative activity of 5-fluorouracil (5-FU) was investigated using human pancreatic cancer cells (2,3).…”
Section: Introductionmentioning
confidence: 99%
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“…Mucins (MUCs) are genes that are reported to influence homeostasis and carcinogenesis. Particularly in pancreatic cancer MUC1 and MUC2 are showed to be specific markers of aggressive types (66). It has been shown that MUC protein expression can be measured by EUS-FNA.…”
Section: Current Practice and The Updates On The Genomic Fieldmentioning
confidence: 99%
“…Multiple mucins are erroneously expressed in pancreatic cancer, in contrast to healthy pancreas which is devoid of mucins or expresses them at low levels. With emerging recognition of the role of mucins in malignancy of tumors, it is becoming evident that pancreatic cancer cells exploit the properties of mucins to interact with their microenvironment, survive in an inhospitable local environment, and metastasise to distant sites [25]. Numerous reports have suggested that MUC1 [26], MUC4 [27], MUC16 [28] and MUC20 [29] expression is increased in pancreatic cancers.…”
Section: Introductionmentioning
confidence: 99%