Muco-ciliary transport: Effect of mucus viscosity, cilia beat frequency and cilia density

Lee, W.L.; Jayathilake, Pahala Gedara; Tan, Zhijun; Le, Duc Vinh; Lee, H.P.; Khoo, Boo Cheong

doi:10.1016/j.compfluid.2011.05.016

Cited by 76 publications

(77 citation statements)

References 42 publications

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“…Similarly, the third assumption is one made out of necessity, as there is a lack of data on the actual force density distribution generated by the ependymal cilia. This distribution could, principally, be determined based on analytical [41] or computational models [42][43][44][45], or be derived from measured velocity profiles. If the true force density distribution has a steeper slope than assumed here, our model would underestimate the effect of the cilia.…”

Section: Limitationsmentioning

confidence: 99%

Flow induced by ependymal cilia dominates near-wall cerebrospinal fluid dynamics in the lateral ventricles

Siyahhan

Knobloch

Zélicourt

et al. 2014

J. R. Soc. Interface.

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While there is growing experimental evidence that cerebrospinal fluid (CSF) flow induced by the beating of ependymal cilia is an important factor for neuronal guidance, the respective contribution of vascular pulsation-driven macroscale oscillatory CSF flow remains unclear. This work uses computational fluid dynamics to elucidate the interplay between macroscale and cilia-induced CSF flows and their relative impact on near-wall dynamics. Physiological macroscale CSF dynamics are simulated in the ventricular space using subject-specific anatomy, wall motion and choroid plexus pulsations derived from magnetic resonance imaging. Near-wall flow is quantified in two subdomains selected from the right lateral ventricle, for which dynamic boundary conditions are extracted from the macroscale simulations. When cilia are neglected, CSF pulsation leads to periodic flow reversals along the ventricular surface, resulting in close to zero time-averaged force on the ventricle wall. The cilia promote more aligned wall shear stresses that are on average two orders of magnitude larger compared with those produced by macroscopic pulsatile flow. These findings indicate that CSF flow-mediated neuronal guidance is likely to be dominated by the action of the ependymal cilia in the lateral ventricles, whereas CSF dynamics in the centre regions of the ventricles is driven predominantly by wall motion and choroid plexus pulsation.

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Section: Limitationsmentioning

confidence: 99%

Flow induced by ependymal cilia dominates near-wall cerebrospinal fluid dynamics in the lateral ventricles

Siyahhan

Knobloch

Zélicourt

et al. 2014

J. R. Soc. Interface.

View full text Add to dashboard Cite

show abstract

“…1 , the standard no-slip condition is prescribed on the lung wall at bottom boundary. The top boundary where air moves above the mucus is assumed to free-slip boundary [5,17,18] . In this study the flow is assumed to be periodic in the horizontal direction.…”

Section: Governing Equationsmentioning

confidence: 99%

“…These cilia have two quite distinct stages of their beating cycle in which the effective stroke is when the cilium is extended out of the cell surface and the recovery stroke is when it moves back slowly to the start of its effective stroke. The effective stroke occupies a shorter period of the beat than the recovery stroke so the work done during the effective stroke is several times the amount of work done during the recovery stroke [5] .…”

Section: Introductionmentioning

confidence: 99%

“…This method was introduced by Peskin [8] at the first time for studying the flow patterns around heart valves and blood flow in the heart [9] . The IBM has been used by many researchers, especially in solving biological problems [5,[10][11][12][13][14][15][16][17][18] . Lee et al [5] used a hybrid immersed boundary-finite difference method to simulate the muco-ciliary transport process.…”

Section: Introductionmentioning

confidence: 99%

“…The IBM has been used by many researchers, especially in solving biological problems [5,[10][11][12][13][14][15][16][17][18] . Lee et al [5] used a hybrid immersed boundary-finite difference method to simulate the muco-ciliary transport process. The effects of the viscosity of the mucus, the cilia beat frequency, the numbers of cilia, the thickness of PCL and the surface tension at the interface between the mucus and PCL on the mean mucus velocity have been studied by them.…”

Section: Introductionmentioning

confidence: 99%

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