Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles

Bravo‐Osuna, Irene; Vauthier, Christine; Farabollini, Alessandra; Palmieri, Gianni; Ponchel, Gilles

doi:10.1016/j.biomaterials.2007.01.005

Cited by 287 publications

(164 citation statements)

References 48 publications

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“…Chitosan is a semi-synthetic polymer obtained by the deacetylation of chitin and has been extensively investigated as a drug delivery mucoadhesive systems (Woodley, 2001). Studies have demonstrated that chitosan can promote the absorption of hydrophilic molecules by the structural reorganization of the proteins associated to the intercellular junctions (Bravo-Osuna et al, 2007). The presence of chitosan at the surface of nanoparticles clearly increased their intestinal mucoadhesive behavior in rats (Bravo-Osuna et al, 2007).…”

Section: First Generation Mucoadhesive Materialsmentioning

confidence: 99%

“…Studies have demonstrated that chitosan can promote the absorption of hydrophilic molecules by the structural reorganization of the proteins associated to the intercellular junctions (Bravo-Osuna et al, 2007). The presence of chitosan at the surface of nanoparticles clearly increased their intestinal mucoadhesive behavior in rats (Bravo-Osuna et al, 2007). Bocataj et al (2003) demonstrated in their studies that chitosan showed higher mucoadhesion than carboxymethylcellulose and polycarbophil.…”

Section: First Generation Mucoadhesive Materialsmentioning

confidence: 99%

“…They are an alternative to non-specific bioadhesives (Smart, 2005) because they bind or adhere to specific chemical structures on the cell or mucus surface. Good examples of these molecules are lectins, invasins, fimbrial proteins (Woodley, 2001), antibodies (Chowdary, Rao, 2004), and those obtained by the addition of thiol groups to known molecules (Bravo-Osuna et al, 2007).…”

Section: Second Generation Mucoadhesive Materialsmentioning

confidence: 99%

“…Bravo-Osuna et al (2007) showed that thiolated chitosan increased mucoadhesive properties due to formation of disulfide bridges with cystein domains of glycoproteins of the mucus. Additionally, these products promoted mucus permeation by a mechanism of glutathione regeneration.…”

Section: Second Generation Mucoadhesive Materialsmentioning

confidence: 99%

“…This approach to confer Bioadhesion properties has been widely applied in the development of a number of drug delivery systems. Solid micro-and nano-particulate systems based on chitosan and derivatives have been the focus of several studies (Bravo-Osuna et al, 2007;Wittaya-Areekul, Kruenate, Prahsarn, 2006): microemulsions are thermodynamically stable and isotropic liquid systems, which allow the incorporation of bioadhesive molecules, such as polycarbophil (Vyas et al, 2006); colloidal dispersions of bioadhesive polymers frequently used in preparations for oral hygiene (Kockisch et al, 2001); semi-solid systems, as liquid crystalline mesophases (Bruschi et al, 2007(Bruschi et al, , 2008 and hydrogels (Bruschi et al, 2007;Huang et al, 2000), which can increase the contact time between preparation and mucous membrane after they undergo in situ gelation.…”

Section: Introductionmentioning

confidence: 99%

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Mucoadhesive drug delivery systems

Carvalho

Bruschi

Evangelista

et al. 2010

Braz. J. Pharm. Sci.

255

181

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Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.Uniterms: Mucoadhesion. Bioadhesion. Mucoadhesive systems. Drugs/delivery. O efeito de fármacos pode ser potencializado através do desenvolvimento de novos sistemas de liberação como os sistemas mucoadesivos. Estes sistemas permanecem em contato íntimo com o tecido de absorção, as mucosas, liberando o fármaco no local de ação, com o consequente aumento da biodisponibilidade, podendo promover efeitos locais e sistêmicos. A mucoadesão, atualmente, é explicada por seis teorias, a eletrônica, da adsorção, da molhabilidade, da difusão, da fratura e a mecânica. Para estudar seus mecanismos e quantificá-la, são propostas várias metodologias in vitro e in vivo. Porém, a mucoadesão ainda não é totalmente compreendida. Esse trabalho tem por objetivo revisar os mecanismos e as teorias envolvidas na mucoadesão, além de descrever as metodologias e os polímeros mais utilizados em sistemas mucoadesivos para liberação de fármacos.Unitermos: Mucoadesão. Bioadesão. Sistemas mucoadesivos. Fármacos/liberação.

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Section: First Generation Mucoadhesive Materialsmentioning

confidence: 99%