Mucoadhesive and Elastic Films Based on Blends of Chitosan and Hydroxyethylcellulose

Abstract

Mucoadhesive polymeric films have been prepared based on blends of chitosan and hydroxyethylcellulose. The blends have been characterized by IR spectroscopy, DSC, WAXD, TGA, SEM, and mechanical testing. It is demonstrated that the mechanical properties of chitosan are improved significantly upon blending with hydroxyethylcellulose. An increase in hydroxyethylcellulose content in the blends makes the materials more elastic. The thermal treatment of the blends at 100 degrees C leads to partial cross-linking of the polymers and formation of water-insoluble but swellable materials. The adhesion of the films towards porcine buccal mucosa decreases with increasing hydroxyethylcellulose content in the blends.

Exploring the Factors Affecting the Solubility of Chitosan in Water

“…These solutions were analyzed over a broad range of pH in a manner similar to the experiments with unmodified chitosan. Interestingly, HACHI was found to be soluble over the whole range of pH tested (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) in both urea (2-8 mol Á L À1 ) and guanidine hydrochloride (1.5-6.0 mol Á L À1 ) solutions, as turbidity measurements remained at baseline values (data not shown). These findings demonstrate that the reduced polysaccharide crystallinity, combined with the presence of urea or guanidine hydrochloride, result in solubility of HACHI over a broad range of pH.…”

“…In our previous publications, [5,32] we reported X-ray diffractograms of chitosan films, which showed four main diffraction peaks (2u ¼ 8.3, 11.3, 18.1, 22.48), confirming the presence of crystalline domains in their structures. Here, we recorded X-ray diffraction spectra for chitosan and its halfacetylated and fully deacetylated derivatives in the form of lyophilized wavers (Figure 2).…”

“…It is a biocompatible and biodegradable material, produced commercially by alkali N-deacetylation of chitin, the main constituent of crustacean exoskeletons. [1,2] Chitosan has a number of unique physicochemical and biological features including its cationic nature and film forming ability, [3,4] mucoadhesive, [5,6] antimicrobial, and wound healing properties, [7] the ability to bind lipids and fatty acids [8,9] and to enhance penetration through mucosal membranes. [10] It has been recognized as a valuable material for potential applications in drug and gene delivery, [11,12] transdermal, [13] and transmucosal formulations [14] and implants.…”

Characterization of chitosan microparticles reinforced cellulose biocomposite sponges regenerated from ionic liquid

“…The -NH bending in amides and amines was no longer observed in the spectra of the composite sponges because the band shifted to a higher frequency overlapping with the carbonyl stretch in amides. This shifting indicated that the -NH groups of chitosan were involved in hydrogen bonding with the functional groups of cellulose (Luo et al 2008). The interaction between cellulose and chitosan was also identified by the hydroxyl group band present in the range of 3,300-3,500 cm -1 .…”

Effect of the Organobentonite Filler on Structure and Properties of Composites Based on Hydroxyethyl Cellulose

“…Figure 7 shows the X-ray diffraction patterns of pure HEC and HEC/organobentonite composites. Pure HEC film shows the presence of two broad diffraction maxima (halo) centered at 2 = 9 ∘ -10 ∘ and 20 ∘ (Figure 7, pattern 1), which are typical for the semicrystalline structure of this polymer [36,37]. The absence of HEC reflection at angles smaller than 8…”