Mucoadhesive drug carriers based on complexes of poly(acrylic acid) and PEGylated drugs having hydrolysable PEG–anhydride–drug linkages

Lele, B. S.; Hoffman, Allan S.

doi:10.1016/s0168-3659(00)00303-5

Cited by 130 publications

(87 citation statements)

References 23 publications

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“…Gelatin-based systems can give zero order release of biologically active agents such as drugs, peptides and proteins. [72] It is possible to entrap bioactive compounds into pegylated liposome-gelatin gel.…”

Section: Gelatinmentioning

confidence: 99%

A Systematic Review on Mucoadhesive Drug Delivery System

Tandel¹

2017

WJPR

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The prospect of writing this review article is to present comprehensive information related to mucoadhesion and mucoadhesive drug delivery systems. The article has highlighted all the aspects of mucoadhesive drug delivery systems which will be helpful for researches and academics. The article includes detailed information about mucosa-the anatomy and physiology, the mechanisms and theories related to mucoadhesion, evaluation parameters of mucoadhesive dosage forms, mucoadhesive polymers and novel approaches related to mucoadhesive drug delivery system. The potential merits and demerits of mucoadhesive drug delivery as well as that of the polymers are also discussed.

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Section: Gelatinmentioning

confidence: 99%

A Systematic Review on Mucoadhesive Drug Delivery System

Tandel¹

2017

WJPR

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“…Poly Acrylic Acid forms hydrogen bonds between its carboxylic acid groups and sialic acidcarboxylic acid groups present in the mucus [ 40 ]. The most recent method for synthesis of Alginate PEG-Ac is a two stage procedure.…”

Section: Thiomersmentioning

confidence: 99%

Novel Mucoadhesive Polymers for Nasal Drug Delivery

Anand¹,

Feridooni²,

Agu³

2012

Recent Advances in Novel Drug Carrier Systems

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“…In this study, we have selected a specially designed buccal film. Ethyl cellulose (EC) was used as the backing layer and hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) were used as the drug-containing layer [10][11][12][13][14] . Therefore, the aim of this study was to develop a bi-layered strip consisting of a tooth-adhesive layer and a non-adhesive protective layer to deliver lidocaine.…”

Section: Introductionmentioning

confidence: 99%

The <i>in vitro</i> and <i>in vivo</i> effects of a fast-dissolving mucoadhesive bi-layered strip as topical anesthetics

et al. 2016

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To overcome pain on injection, the dentist can apply a topical anesthetic spray. Despite the convenience, it is not easy to apply it locally. So, we developed an oral mucoadhesive bi-layer film containing an anesthetic. We used polyvinylpyrrolidone (PVP)/ hydroxypropyl methylcellulose (HPMC) and HPMC-only layer as the drug-containing layer and ethyl cellulose (EC) as the backing layer. The lidocaine released was tested in vitro together with the adhesion time and cytotoxicity of the film. Mucosa permeability was tested in vivo. Statistical analysis was performed, with p at 0.05 taken to be significant. The lidocaine was released significantly faster in the PVP/HPMC than HPMC-only group and 80% of the drug was released within 1 min (p<0.05) and they attached at least 3 h. The test groups showed no toxicity and the drug effectively permeated the mucosa (p<0.05). We suggest this new mucoadhesive anesthetic may reduce dental phobia.

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Mucoadhesive drug carriers based on complexes of poly(acrylic acid) and PEGylated drugs having hydrolysable PEG–anhydride–drug linkages

Cited by 130 publications

References 23 publications

A Systematic Review on Mucoadhesive Drug Delivery System

A Systematic Review on Mucoadhesive Drug Delivery System

Novel Mucoadhesive Polymers for Nasal Drug Delivery

The <i>in vitro</i> and <i>in vivo</i> effects of a fast-dissolving mucoadhesive bi-layered strip as topical anesthetics

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