Mucoadhesive electrospun chitosan-based nanofibre mats for dental caries prevention

Samprasit, Wipada; Kaomongkolgit, Ruchadaporn; Sukma, Monrudee; Rojanarata, Theerasak; Ngawhirunpat, Tanasait; Opanasopit, Praneet

doi:10.1016/j.carbpol.2014.10.026

Cited by 78 publications

(49 citation statements)

References 23 publications

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“…They are classified into polyphenolic compounds and have been reported to have high antioxidant activities [2][3][4]. Some delivery methods to improve the bioavailability of -mangostin have recently been studied, including microgel [5], solid dispersion [6], microsphere [7], and nanofiber mat [8].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Sriyanti

Edikresnha

Rahma

et al. 2017

Journal of Nanomaterials

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Nanofiber mats of polyvinyl(pyrrolidone) (PVP) with Garcinia mangostana extract (GME) as the encapsulated drug have been developed using electrospinning. SEM images of all electrospun PVP/GME composite nanofiber mats showed that they had similar and smooth morphology, no beads, and spindle shape. Its average diameter decreased and its surface area therefore increased with the decrease of its PVP concentration. The benefit of high surface area is obvious in drug delivery systems for poorly water-soluble drugs. Their FTIR spectra indicated that PVP and GME interacted intermolecularly via hydrogen bonds in the composite nanofiber mats. A conformational change in the C-H chain of PVP occurred in the composite nanofiber mats due to the intermolecular interactions. Their XRD patterns confirmed that they were amorphous because of amorphization during electrospinning. The XRD analyses also strengthened the FTIR studies; namely, GME and PVP formed intermolecular interactions in the electrospun composite nanofiber mats. As a result, GME as the encapsulated drug was molecularly dispersed in the electrospun PVP nanofiber matrix that functioned as a drug delivery system. From the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the composite nanofiber mats exhibited very high antioxidant activities despite having been exposed to high voltage during electrospinning. Therefore, they are potential antioxidant products for food and pharmaceutics.

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Section: Introductionmentioning

confidence: 99%

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Sriyanti

Edikresnha

Rahma

et al. 2017

Journal of Nanomaterials

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show abstract

“…60 Oral hijyenin sağlanması amacıyla ağız gargaralarında ve çürük oluşumunu önlemek ve bakteriyal çoğalmayı azaltmak için kullanılabileceği belirtilmiştir. 61,62 Demineralizasyonu inhibe ettiği ve tamir dentini oluşumunu sağladığı gösterilmiştir. 63,64 Hidrojeller; kitozanın kullanıldığı başka bir ilaç taşıyıcı sistemdir.…”

Section: Kitozanın Biyomedikal Ve Farmasötik Uygulamalarıunclassified

Di̇ş Heki̇mli̇ği̇nde Ki̇ti̇n Ve Ki̇tozan

Oyar¹

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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“…60 Çürük oluşumunu önlemek ve bakteriyal çoğal-mayı azaltmak için oral hijyenin sağlanması amacıyla ağız gargaralarında kullanılabileceği belirtilmiştir. 61,62 Tamir dentini oluşumunu sağladığı ve demineralizasyonu inhibe ettiği bulunmuştur. 63,64 Kitozanın kullanıldığı başka bir ilaç taşıyıcı sistem hidrojellerdir.…”

Section: Kitozanın Biyomedikal Ve Farmasötik Uygulamalarıunclassified

Di̇ş Heki̇mli̇ği̇nde Ki̇ti̇n Ve Ki̇tozan

OYAR¹

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Mucoadhesive electrospun chitosan-based nanofibre mats for dental caries prevention

Cited by 78 publications

References 23 publications

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Di̇ş Heki̇mli̇ği̇nde Ki̇ti̇n Ve Ki̇tozan

Di̇ş Heki̇mli̇ği̇nde Ki̇ti̇n Ve Ki̇tozan

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