Mucoadhesive Micro-/Nano Carriers in Ophthalmic Drug Delivery: an Overview

Naik, Jitendra; Pardeshi, Sagar R.; Patil, Rahul; Patil, Pritam; Mujumdar, Arun S.

doi:10.1007/s12668-020-00752-y

Cited by 39 publications

(10 citation statements)

References 130 publications

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“…The eye is a highly sensitive organ, being exposed to both environmental harm and internal damaging factors, such as age, genetics, and diabetes. Nonetheless, the eye is protected by several anatomic and physiological barriers (e.g., blinking, different membraneous layers, blood-retinal barrier, choroidal and conjunctival blood flow, lymphatic clearance, lacrimation) that limit the supply of drugs to affected tissues [71,[89][90][91]. Thus, developing nanocarriers for ocular delivery became necessary for improving drugs bioavailability, controlling drug release, decreasing the frequency of administrations, and increasing therapeutic efficiency [71,92,93].…”

Section: Ocular Deliverymentioning

confidence: 99%

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

2022

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Chitosan and alginate are two of the most studied natural polymers that have attracted interest for multiple uses in their nano form. The biomedical field is one of the domains benefiting the most from the development of nanotechnology, as increasing research interest has been oriented to developing chitosan-alginate biocompatible delivery vehicles, antimicrobial agents, and vaccine adjuvants. Moreover, these nanomaterials of natural origin have also become appealing for environmental protection (e.g., water treatment, environmental-friendly fertilizers, herbicides, and pesticides) and the food industry. In this respect, the present paper aims to discuss some of the newest applications of chitosan-alginate-based nanomaterials and serve as an inception point for further research in the field.

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Section: Ocular Deliverymentioning

confidence: 99%

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

2022

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“…Micro/nanocarriers are organic and polymeric materials that are structurally oriented to act like capsules in aqueous and organic media in order to protect, transport, and release cargo [64][65][66][67], among other applications. Liposomes are organic micro/nanocarriers based on phospholipids that form vesicles [68].…”

Section: Organic and Polymeric Micro/nanocarriersmentioning

confidence: 99%

Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery

Mena-Giraldo

Orozco

2021

Polymers

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Smart polymer-based micro/nanoassemblies have emerged as a promising alternative for transporting and delivering a myriad of cargo. Cargo encapsulation into (or linked to) polymeric micro/nanocarrier (PC) strategies may help to conserve cargo activity and functionality when interacting with its surroundings in its journey to the target. PCs for cargo phototriggering allow for excellent spatiotemporal control via irradiation as an external stimulus, thus regulating the delivery kinetics of cargo and potentially increasing its therapeutic effect. Micromotors based on PCs offer an accelerated cargo–medium interaction for biomedical, environmental, and many other applications. This review collects the recent achievements in PC development based on nanomicelles, nanospheres, and nanopolymersomes, among others, with enhanced properties to increase cargo protection and cargo release efficiency triggered by ultraviolet (UV) and near-infrared (NIR) irradiation, including light-stimulated polymeric micromotors for propulsion, cargo transport, biosensing, and photo-thermal therapy. We emphasize the challenges of positioning PCs as drug delivery systems, as well as the outstanding opportunities of light-stimulated polymeric micromotors for practical applications.

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“…15 HA hygroscopic characteristic enables it to form hydrogen bonds with mucin despite its anionic nature. 16 HA is a biodegradable, non-immunogenic biopolymer, and might be an interesting molecule for targeted ocular delivery since it is a major constituent of the vitreous humor. It is found throughout the retina and has the ability to interact with Cluster of differentiation (CD44) receptors on the surface of many retinal cell types.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic-Coated Albumin Nanoparticles for the Non-Invasive Delivery of Apatinib in Diabetic Retinopathy

Radwan¹,

El-Kamel²,

Zaki³

et al. 2021

IJN

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Purpose Apatinib (Apa) is a novel anti-vascular endothelial growth factor with the potential to treat diabetic retinopathy (DR); a serious condition leading to visual impairment and blindness. DR treatment relies on invasive techniques associated with various complications. Investigating topical routes for Apa delivery to the posterior eye segment is thus promising but also challenging due to ocular barriers. Hence, the study objective was to develop Apa-loaded bovine serum albumin nanoparticles (Apa-BSA-NPs) coated with hyaluronic acid (HA); a natural polymer possessing unique mucoadhesive and viscoelastic features with the capacity to actively target CD44 positive retinal cells, for topical administration in DR. Methods Apa-BSA-NPs were prepared by desolvation using glutaraldehyde for cross-linking. HA-coated BSA-NPs were also prepared and HA: NPs ratio optimized. Nanoparticles were characterized for colloidal properties, entrapment efficiency (EE%), in vitro drug release and mucoadhesive potential. In vitro cytotoxicity on rabbit corneal epithelial cells (RCE) was assessed using MTT assay, while efficacy was evaluated in vivo in a diabetic rat model by histopathological examination of the retina by light and transmission electron microscopy. Retinal accumulation of fluorescently labeled BSA-NP and HA-BSA-NP was assessed using confocal microscope scanning. Results Apa-HA-BSA-NPs prepared under optimal conditions showed size, PdI and zeta potential: 222.2±3.56 nm, 0.221±0.02 and −37.3±1.8 mV, respectively. High EE% (69±1%), biphasic sustained release profile with an initial burst effect and mucoadhesion was attained. No evidence of cytotoxicity was observed on RCE cells. In vivo histopathological studies on DR rat model revealed alleviated retinal micro- and ultrastructural changes in the topical HA-Apa-BSA-NP treated eyes with normal basement membrane and retinal thickness comparable to normal control and intravitreally injected nanoparticles. Improved retinal accumulation for HA-BSA-NP was also observed by confocal microscopy. Conclusion Findings present HA-Apa-BSA-NPs as a platform for enhanced topical therapy of DR overcoming the devastating ocular complications of the intravitreal route.

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Mucoadhesive Micro-/Nano Carriers in Ophthalmic Drug Delivery: an Overview

Cited by 39 publications

References 130 publications

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery

Hyaluronic-Coated Albumin Nanoparticles for the Non-Invasive Delivery of Apatinib in Diabetic Retinopathy

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