Mucoadhesive Oro-Gel–Containing Chitosan Lipidic Nanoparticles for the Management of Oral Squamous Cell Carcinoma

Gharat, Sankalp; Basudkar, Vivek; Momin, Munira; Prabhu, A. Antony Muthu

doi:10.1007/s12247-023-09724-7

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…The required time (in seconds) by the glass to slip off from the nanoemulgel in the direction of certain load was recorded. The spreadability of the nanoemulgel is inversely proportional to the time required for complete separation of glass slides [33,34]. Spreading was calculated using the mathematical formula.…”

Section: Evaluation and Characterization Of Nanoemulsion Loaded Gel P...mentioning

confidence: 99%

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Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the management of rheumatoid arthritis

Chando,

Basudkar,

Gharat

et al. 2023

Drug Deliv. and Transl. Res.

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In recent years, natural ingredients have gained importance for therapeutic treatment due to their minimal toxicity. However, the delivery of these phytoconstituents poses a challenge to provide better e cacy. Current research reports the development of nanoemulgel (NEG) loaded with ginger oleoresin (GOR) and lipid guggul extract (LGE) for the management of rheumatoid arthritis (RA). The nanoemulsion (NE) was developed using the spontaneous emulsi cation technique by the pseudo-ternary method. The optimized nanoemulsion exhibited globule size of 16.08±2.55, PDI of 0.187±0.06 and Zeta Potential of-22.4±0.31.The cumulative release from in-vitro diffusion studies at pH 7.4 was about 99.72±3.47%, 57.98±2.11% and 86.42±5.13% of 6-gingerol, E-guggulsterone and Z-guggulsterone respectively at the end of 24 hours.The ex vivo studies on porcine ear skin showed sustained release with 92.8±3.21% for 6-gingerol, 55.61±0.91% for E-guggulsterone, and 84.2±4.22% for Z-guggulsterone released at the end of 24 hours. The cell culture studies on RAW 264.7 cells indicated a robust inhibition of LPS-induced IL-6 and TNF-α production indicating its e cacy in the management of RA. The Preclinical studies on male Wistar rats suggests that the developed NEG exhibited a comparable decrease in paw edema in ammation as compared to the marketed diclofenac sodium gel. These encouraging results demonstrates the potential of the developed nanoemulgel containing combination of GOR and LGE for the management of RA.

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Section: Evaluation and Characterization Of Nanoemulsion Loaded Gel P...mentioning

confidence: 99%

“…Later, MTT solution was replaced with 100 µL of dimethyl sulfoxide (DMSO) (Millipore sigma) for solubilizing the purple formazan crystals. The absorbance was recorded using an ELISA microplate reader ( BioTek Synergy H1 Multimode Reader, USA) at λ max = 570 nm and 630 nm [33,42].…”

Section: Differential Scanning Colorimetrymentioning

confidence: 99%

Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the management of rheumatoid arthritis

Chando,

Basudkar,

Gharat

et al. 2023

Drug Deliv. and Transl. Res.

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In-Vitro and in-Vivo Evaluation of the Developed Curcumin-Cyclosporine-Loaded Nanoemulgel for the Management of Rheumatoid Arthritis

Gharat,

Basudkar,

Momin

2024

Immunological Investigations

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Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the management of rheumatoid arthritis

Chando¹,

Basudkar

Gharat

et al. 2023

Preprint

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In recent years, natural ingredients have gained importance for therapeutic treatment due to their minimal toxicity. However, the delivery of these phytoconstituents poses a challenge to provide better efficacy. Current research reports the development of nanoemulgel (NEG) loaded with ginger oleoresin (GOR) and lipid guggul extract (LGE) for the management of rheumatoid arthritis (RA). The nanoemulsion (NE) was developed using the spontaneous emulsification technique by the pseudo-ternary method. The optimized nanoemulsion exhibited globule size of 16.08±2.55, PDI of 0.187±0.06 and Zeta Potential of-22.4±0.31. The cumulative release from in-vitro diffusion studies at pH 7.4 was about 99.72±3.47%, 57.98±2.11% and 86.42±5.13% of 6-gingerol, E-guggulsterone and Z-guggulsterone respectively at the end of 24 hours. The ex vivo studies on porcine ear skin showed sustained release with 92.8±3.21% for 6-gingerol, 55.61±0.91% for E-guggulsterone, and 84.2±4.22% for Z-guggulsterone released at the end of 24 hours. The cell culture studies on RAW 264.7 cells indicated a robust inhibition of LPS-induced IL-6 and TNF-α production indicating its efficacy in the management of RA. The Preclinical studies on male Wistar rats suggests that the developed NEG exhibited a comparable decrease in paw edema inflammation as compared to the marketed diclofenac sodium gel. These encouraging results demonstrates the potential of the developed nanoemulgel containing combination of GOR and LGE for the management of RA.

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Mucoadhesive Oro-Gel–Containing Chitosan Lipidic Nanoparticles for the Management of Oral Squamous Cell Carcinoma

Cited by 3 publications

References 39 publications

Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the management of rheumatoid arthritis

Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the management of rheumatoid arthritis

In-Vitro and in-Vivo Evaluation of the Developed Curcumin-Cyclosporine-Loaded Nanoemulgel for the Management of Rheumatoid Arthritis

Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the management of rheumatoid arthritis

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