Mucocutaneous manifestations of HIV‐infected patients in the era of HAART in Guangxi Zhuang Autonomous Region, China

Han, Junyan; Lun, Wenhui; Meng, Zhihao; Huang, Kui; Mao, Yurong; Zhu, Wei; Lian, Shi

doi:10.1111/j.1468-3083.2011.04429.x

Cited by 28 publications

(34 citation statements)

References 31 publications

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“…However some of the lesions were nonspecific. There was a positive correlation between CD4 cell counts and mucocutaneous manifestations in our study which were similar to findings of Han et al 24 The mean CD4 cell count in the study group was 277.24 cells/mm3 which is similar to reports of many studies in India. 25 Most of the mucocutaneous manifestations were noticed in stag-3 and stage 4.…”

Section: Discussionsupporting

confidence: 82%

Mucocutaneous manifestations in newly diagnosed cases of HIV, correlation with CD4 counts and WHO staging at a tertiary care center

2017

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Background:Mucocutaneous infections have played an important role in initial diagnosis of HIV infection and in clinical staging of the disease. Mucocutaneous manifestations in HIV infected individuals are myriad and can serve as a main indicator of other problems. Health care personnel involved in HIV health care must therefore have a clear idea of type, pattern, and prevalence of skin diseases in their locality. The objective of the study was to determine the various mucocutaneous manifestations in newly diagnosed cases of HIV and to correlate them with CD4 cell counts. The manifestations and CD4 cell counts are correlated with WHO staging of the disease.Methods:Data was collected from all the newly diagnosed cases of HIV presenting to the Department of Dermatology. Thorough clinical examination was done and findings were noted. CD4 cell counts were performed by FACS counter and supportive laboratory tests were done for diagnosis of other skin manifestations.Results:250 cases were enrolled with males 148 and 102 females. Most common age group was middle age group and hetero sexual route was the most common route of transmission. Bacterial skin infections were more common and candidiasis was most common among fungal infections. Herpes zoster was most common in viral infections. Significant correlation was observed between CD4 cell counts and WHO clinical staging of disease. Majority of infections were more common at advanced stage of HIV.Conclusions:To conclude, HIV-related mucocutaneous manifestations are a good clinical clue in diagnosis of advanced stages of HIV. Most of these manifestations can serve as diagnostic and prognostic markers in HIV infection. Management of HIV related mucocutaneous manifestations should always be precluded with a screening of CD4 cell counts. A lowered CD4 cell counts will prolong the duration of treatment and may significantly alter the outcome of the disease.

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Section: Discussionsupporting

confidence: 82%

Mucocutaneous manifestations in newly diagnosed cases of HIV, correlation with CD4 counts and WHO staging at a tertiary care center

2017

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“…Though fungal infections were the most common infections occurring in 30 patients (17.6%) followed by viral (10.6%) and bacterial (9.4%) infections in our study, the overall prevalence is low compared to previous studies in the literature. [12] This could be attributed to the fact that most of our patients were on HAART.…”

Section: Discussionmentioning

confidence: 99%

“…The mean CD4 count of patients with candidiasis (120 cells/mm 3 ) was significantly low compared to those without candidiasis as observed in previous studies wherein candidiasis occurred with low CD4 count (<200 cells/mm 3 ). [14]…”

Section: Discussionmentioning

confidence: 99%

“…The pervasive use of HAART may also have changed the patterns and rates of HIV-related cutaneous manifestations. [1] Although, mucocutaneous lesions have diminished in their frequency following the introduction of HAART, the therapy itself can lead to increased incidence of adverse cutaneous drug reactions. [2] Hence, we undertook this study to study the various mucocutaneous manifestations encountered in treatment-naïve HIV-infected individuals and those on HAART.…”

Section: Introductionmentioning

confidence: 99%

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Effect of antiretroviral therapy on mucocutaneous manifestations among Human Immunodeficiency Virus-infected patients in a tertiary care centre in South India

Nagendran

Jaisankar

Hamide

et al. 2015

Indian J Sex Transm Dis

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Background:Human Immunodeficiency Virus (HIV) infection produces a wide range of infectious and noninfectious dermatoses which correlate with the degree of immunodeficiency. Since the introduction of highly active antiretroviral therapy (HAART), there has been a dramatic decrease in the incidence of HIV-associated dermatoses. However, HAART itself causes various cutaneous adverse drug reactions.Aims:To assess the various mucocutaneous manifestations in HIV-infected individuals and its association with CD4 count and to assess the effect of HAART on mucocutaneous manifestations.Materials and Methods:Of the 170 patients recruited, 110 patients were previously diagnosed with HIV and were on follow-up. The rest 60 patients were newly diagnosed cases at recruitment, and these patients were followed up every month for mucocutaneous manifestations for a period of 6 months.Results:Of the 170 patients screened, 69.41% patients had at least one mucocutaneous lesion at presentation. Fungal, viral, and bacterial infections were observed present in 17.6%, 10.6%, and 9.4% patients, respectively. There was a significant difference in the occurrence of candidal infections in the HAART versus non-HAART group (P = 0.0002). Candidiasis (P ≤ 0.0001) and human papillomavirus infection (P = 0.0475) occurred more commonly with CD4 count <200 cells/mm 3 . Among the noninfectious dermatoses, inflammatory dermatoses (17.6%) were more commonly observed at recruitment followed by adverse cutaneous drug reactions (16.5%) and neoplasms (5.3%).Conclusion:HAART has significantly altered the patterns of mucocutaneous manifestations. The prevalence of both infectious and inflammatory dermatoses has come down. However, there is an increase in the incidence of adverse cutaneous drug reactions.

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“…Inhaled P. marneffei conidia are engulfed by the macrophages and processed in the reticuloendothelial system [35]. The organisms then remain dormant and proliferate upon deterioration of the immune system of the host.…”

Section: Penicilliosismentioning

confidence: 99%

Skin and subcutaneous infections in south-east Asia

Nor

Baseri

2015

Current Opinion in Infectious Diseases

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Mucocutaneous manifestations of HIV‐infected patients in the era of HAART in Guangxi Zhuang Autonomous Region, China

Abstract: A wide range of mucocutaneous disorders were observed in HIV-infected Chinese patients. Oral candidiasis, P. marneffei infection and PPE may be the signs of advanced HIV infection. HAART had an impact on the spectrum of HIV-associated mucocutaneous disorders.

Cited by 28 publications

References 31 publications

Mucocutaneous manifestations in newly diagnosed cases of HIV, correlation with CD4 counts and WHO staging at a tertiary care center

Mucocutaneous manifestations in newly diagnosed cases of HIV, correlation with CD4 counts and WHO staging at a tertiary care center

Effect of antiretroviral therapy on mucocutaneous manifestations among Human Immunodeficiency Virus-infected patients in a tertiary care centre in South India

Skin and subcutaneous infections in south-east Asia

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