Mucoepidermoid carcinoma. An update and review of the literature

Labrador, Alberto Jose Peraza; Gomez, Raul; Beltran, J. Saez; Amarista, Felix Jose

doi:10.1016/j.jormas.2020.06.003

Cited by 80 publications

(82 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, given the small number of cases studied so far, these findings need to be confirmed further. The less common form is the mucoepidermoid carcinoma, representing about 5% of sinonasal glandular tumors [ 62 , 71 ].…”

Section: Pathological Classification and Histotypesmentioning

confidence: 99%

Malignant Sinonasal Tumors: Update on Histological and Clinical Management

et al. 2021

View full text Add to dashboard Cite

Tumors of nasal cavity and paranasal sinuses (TuNSs) are rare and heterogeneous malignancies, presenting different histological features and clinical behavior. We reviewed the literature about etiology, biology, and clinical features of TuNSs to define pathologic features and possible treatment strategies. From a diagnostic point of view, it is mandatory to have high expertise and perform an immunohistochemical assessment to distinguish between different histotypes. Due to the extreme rarity of these neoplasms, there are no standard and evidence-based therapeutic strategies, lacking prospective and large clinical trials. In fact, most studies are retrospective analyses. Surgery represents the mainstay of treatment of TuNSs for small and localized tumors allowing complete tumor removal. Locally advanced lesions require more demolitive surgery that should be always followed by adjuvant radio- or chemo-radiotherapy. Recurrent/metastatic disease requires palliative chemo- and/or radiotherapy. Many studies emphasize the role of specific genes mutations in the development of TuNSs like mutations in the exons 4–9 of the TP53 gene, in the exon 9 of the PIK3CA gene and in the promoter of the TERT gene. In the near future, this genetic assessment will have new therapeutic implications. Future improvements in the understanding of the etiology, biology, and clinical features of TuNSs are warranted to improve their management.

show abstract

Section: Pathological Classification and Histotypesmentioning

confidence: 99%

Malignant Sinonasal Tumors: Update on Histological and Clinical Management

et al. 2021

View full text Add to dashboard Cite

show abstract

“…MEC is the most common malignancy of the major and minor salivary glands, accounting for 30% of salivary malignancies [ 1 ]. MEC was first established in 1945 by Stewart et al [ 2 ] as being characterized by a mixture of epidermoid and mucus-secreting cells.…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…Mucoepidermoid carcinoma (MEC) is the most common malignancy of the salivary glands [ 1 ]. MEC is uncommon in other parts of the body, especially in the periocular region.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Cutaneous Mucoepidermoid Carcinoma of the Eyelid: A Case Report and Literature Review

Abrou

Abowd

2021

Case Rep Ophthalmol

View full text Add to dashboard Cite

Mucoepidermoid carcinoma (MEC) is most commonly found to affect the salivary glands and rarely affects other organ systems. In this report, we present an especially rare case of cutaneous MEC affecting the eyelid. A 72-years-old female patient presented with a painless, cyst-like, progressively enlarging lesion of the left upper eyelid. Biopsy revealed characteristic features of MEC, including a mixture of mucus-secreting cells and epidermoid cells. The 3 mm MEC lesion was excised by Mohs micrographic surgery, leaving a 0.8 × 1.1 cm eyelid defect that was repaired by oculoplastic reconstruction. To date, the patient has been in remission for 4 years with good functional and aesthetic outcomes. This case represents the longest reported remission among only 9 previously reported cases of cutaneous MEC of the eyelid and highlights the therapeutic and aesthetic efficacy of Mohs micrographic surgery. We also offer a literature review of the 9 previously reported cases of eyelid MEC and a discussion of patient presentation, treatment comparisons, remission success, and key points in the management of MEC of the eyelid.

show abstract

“…MEC was first described as a distinct pathologic entity of salivary gland tumors in 1945 [5] . Since then, MEC has been discovered in multiple sites including the upper respiratory system, esophagus, breast, and thymus [6 , 7] . It accounts for approximately 10%-15% of all salivary gland neoplasms and 30% of all salivary malignancies [8 , 9] .…”

Section: Discussionmentioning

confidence: 99%

“…It accounts for approximately 10%-15% of all salivary gland neoplasms and 30% of all salivary malignancies [8 , 9] . Approximately 50%-60% of these tumors arise in the major salivary glands with more than 80% occurring in the parotid gland, 8-13% arising in the submandibular gland, 2%-4% arising in the sublingual gland, and the remaining tumors originating in the minor salivary glands (most commonly in the palate) [6] . Low-grade MEC most commonly arises in minor salivary glands while the majority of high-grade MEC arises in the major salivary glands and is more frequently associated with higher T and N-staging status [10 , 11] .…”

Section: Discussionmentioning

confidence: 99%

Mucoepidermoid carcinoma of the thymus incidentally diagnosed following two-years of non-productive cough

Thibodeau

Jafroodifar

Coelho

et al. 2021

Radiology Case Reports

View full text Add to dashboard Cite

Mucoepidermoid carcinoma of the thymus is a rare primary thymic carcinoma. Radiologic imaging of this malignancy is rarely reported in literature. We present a patient who complained of a chronic cough for two years who was later found to have mucoepidermoid carcinoma of the thymus. Chest radiograph revealed a large anterior mediastinal mass. Follow-up computed tomography of the thorax demonstrated a large, heterogeneous anterior mediastinal mass with traversing vessels. F-18 fluorodeoxyglucose positron emission tomography-computed tomography demonstrated high avidity in the lesion with areas of diminished activity thought to represent necrosis. Following surgical resection, pathology revealed high-grade mucoepidermoid carcinoma of the thymus extending into the skeletal muscle and pericardium with evidence of lymphovascular invasion. The patient received external beam radiation therapy and has remained disease-free for three years.

show abstract

Mucoepidermoid carcinoma. An update and review of the literature

Cited by 80 publications

References 46 publications

Malignant Sinonasal Tumors: Update on Histological and Clinical Management

Malignant Sinonasal Tumors: Update on Histological and Clinical Management

A Rare Case of Cutaneous Mucoepidermoid Carcinoma of the Eyelid: A Case Report and Literature Review

Mucoepidermoid carcinoma of the thymus incidentally diagnosed following two-years of non-productive cough

Contact Info

Product

Resources

About