Mucoepidermoid Carcinoma of the Breast Found during Treatment of Lymphoma

Fujino, Minoru; Mori, Daisuke; Akashi, Michiaki; Yamamoto, Hidetaka; Aibe, Hitoshi; Matake, Kunishige; Shirahane, Kengo

doi:10.1159/000452792

Cited by 11 publications

(14 citation statements)

References 20 publications

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“…MG in 6 cases showed a well-defined or ill-defined mass with an oval, lobulated, or irregular shape. Only 1 of these involved coarse calcification in the mass on MG. [ 7 ] US examinations in 8 cases showed a solid or complex echoic mass. Five cases of low-grade MEC showed a complex echoic mass with various amounts of anechoic areas representing internal cystic components and 2 cases of intermediate-grade MECs showed a heterogeneous echoic solid mass without internal cystic portion.…”

Section: Discussionmentioning

confidence: 99%

“…Five cases of low-grade MEC showed a complex echoic mass with various amounts of anechoic areas representing internal cystic components and 2 cases of intermediate-grade MECs showed a heterogeneous echoic solid mass without internal cystic portion. [ 7 ] Only 3 cases involved MRI examinations. [ 4 , 7 ] On MRI, 1 case of low-grade MEC showed an enhancing mass with some areas of high signal intensity on the T2-weighted image, representing cystic components, [ 18 ] and 2 cases of intermediate-grade MEC (including our case) showed a heterogeneously enhancing mass without an internal cystic component.…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 ] Only 3 cases involved MRI examinations. [ 4 , 7 ] On MRI, 1 case of low-grade MEC showed an enhancing mass with some areas of high signal intensity on the T2-weighted image, representing cystic components, [ 18 ] and 2 cases of intermediate-grade MEC (including our case) showed a heterogeneously enhancing mass without an internal cystic component. [ 12 ] Our case is the first to present the tumor enhancement kinetics of MEC, which showed rapid initial enhancement, rapid washout, and kinetic heterogeneity in the tumor.…”

Section: Discussionmentioning

confidence: 99%

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Mucoepidermoid carcinoma of the breast: A case report and literature review focused on radiological findings

et al. 2022

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Rationale: Mucoepidermoid carcinoma (MEC) of the breast is a rare entity, with an estimated incidence of only 0.2% to 0.3% of all primary breast tumors. The radiological features of breast MEC have scarcely been investigated mainly because of its rarity. In this article, we present a case of breast MEC diagnosed at our hospital and review the literature, focusing on radiological findings and radiologic–pathologic correlations that could improve clinical management of this entity. To the best of our knowledge, our study is the first review of the literature that focuses on the radiological features of breast MEC. Patient concerns: A 47-year-old premenopausal woman presented with a painless palpable mass in the right breast. Diagnosis: Mammography and ultrasonography revealed a mass with suspicious malignant features, which was categorized as Breast Imaging Reporting and Data System category 4c. A 14-gauge core-needle biopsy revealed an intermediate-grade MEC of the breast. The patient underwent breast magnetic resonance imaging and chest computed tomography for preoperative evaluation. Postoperative histopathological examination confirmed a diagnosis of intermediate-grade MEC. The clinical staging was T2N0M0. Interventions: The patient underwent breast-conserving surgery, adjuvant chemotherapy, radiotherapy, and hormonal therapy. Outcomes: No evidence of recurrence has been reported over 37 months. Lessons: The imaging characteristics of breast MEC were variable, and there were no specific radiological features for diagnosis. The presence of cystic components on radiological imaging is likely to be an indicator of a low-grade tumor and better prognosis, although the number of reported cases is limited.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Mucoepidermoid carcinoma of the breast: A case report and literature review focused on radiological findings

et al. 2022

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“…In a recent review, Ye et al identified 42 cases of breast MEC published from 1979 when Patchefsky et al first described this tumour type in the breast [ 115 ], of which 19 were classified as low grade, 3 as intermediate grade, 17 as high and 3 had no grade reported. Their table has been completed with treatment information and used to summarize the low and intermediate grade cases ( Supplementary Table S5 ) [ 109 , 111 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 ]. In the non-high grade MEC group, 7 patients had BCS (6 low grade and 1 with intermediate grade) and 16 had mastectomy (13 low grade and 3 intermediate grade) [ 108 ].…”

Section: Mucoepidermoid Carcinoma (Mec) Of the Breastmentioning

confidence: 99%

Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis

Cserni

Quinn

Foschini

et al. 2021

Cancers

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Triple-negative breast cancers (TNBC), as a group of tumours, have a worse prognosis than stage-matched non-TNBC and lack the benefits of routinely available targeted therapy. However, TNBC is a heterogeneous group of neoplasms, which includes some special type carcinomas with a relatively indolent course. This review on behalf of the European Working Group for Breast Screening Pathology reviews the literature on the special histological types of BC that are reported to have a triple negative phenotype and indolent behaviour. These include adenoid cystic carcinoma of classical type, low-grade adenosquamous carcinoma, fibromatosis-like metaplastic carcinoma, low-grade mucoepidermoid carcinoma, secretory carcinoma, acinic cell carcinoma, and tall cell carcinoma with reversed polarity. The pathological and known molecular features as well as clinical data including treatment and prognosis of these special TNBC subtypes are summarised and it is concluded that many patients with these rare TNBC pure subtypes are unlikely to benefit from systemic chemotherapy. A consensus statement of the working group relating to the multidisciplinary approach and treatment of these rare tumour types concludes the review.

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“…Salivary gland neoplasms trend toward malignancy as their size decreases. MEC is not exclusive to the major and minor salivary glands, and can be seen in other areas such as the breast 2. Additionally, MEC can be found as a primarily intraosseous lesion, making up 2%–3% of head and neck MEC, with less than 200 cases reported since 1939 3.…”

Section: Introductionmentioning

confidence: 99%

Primary intraosseous mucoepidermoid carcinoma of the mandible: radiographic evolution and clinicopathological features

Abt¹,

Lawler

Zacharias

et al. 2019

BMJ Case Rep

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Mucoepidermoid carcinoma (MEC) can be rarely found as a primarily intraosseous lesion and mistaken for other intraosseous or odontogenic pathology. A 65-year-old man had a poorly defined radiolucency distal to the left mandibular second molar root. Periapical radiographs demonstrated a minor radiolucency from 2.5 years prior. An oral and maxillofacial surgeon felt the radiolucency represented periodontal disease, extracting tooth #18. The differential diagnosis of mixed radiolucent/radio-opaque mandibular lesions includes: (1) fibro-osseous lesion, (2) odontogenic and non-odontogenic cyst, (3) infection and inflammatory lesion, or (4) benign or malignant neoplasm (odontogenic, non-odontogenic, or metastatic). Histological analysis revealed low-grade MEC. A composite resection was performed with a 1 cm margin from first molar to ascending ramus. A buccal fat pad advancement flap covered the defect with an iliac crest bone graft placed later for a resulting osseous defect. Careful examination and diagnostic work-up for odontogenic cysts should be provided as they may harbour malignant tumours.

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Mucoepidermoid Carcinoma of the Breast Found during Treatment of Lymphoma

Cited by 11 publications

References 20 publications

Mucoepidermoid carcinoma of the breast: A case report and literature review focused on radiological findings

Mucoepidermoid carcinoma of the breast: A case report and literature review focused on radiological findings

Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis

Primary intraosseous mucoepidermoid carcinoma of the mandible: radiographic evolution and clinicopathological features

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