Mucoepidermoid carcinoma of the head and neck in children

Dombrowski, Natasha D.; Wolter, Nikolaus E.; Irace, Alexandria L.; Cunningham, Michael J.; Mack, Jennifer W.; Marcus, Karen J.; Vargas, Sara O.; Perez‐Atayde, Antonio R.; Robson, Caroline D.; Rahbar, Reza

doi:10.1016/j.ijporl.2019.02.020

Cited by 21 publications

(14 citation statements)

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“…MEC is the most common malignant tumor of the salivary glands (12%-29%) in children and young adults [9,25,28,29], and according to some authors, the most common malignancy in minor salivary glands [8][9][10][11][12][13]20]; its peak incidence is between the third and sixth decade, with predilection for females [25,28,29]. As confirmed by the results of the present study, the palate remains the most common site for MECs occurring in minor salivary glands, while they less frequently occur in the retromolar area, the floor of the mouth, the buccal mucosa, the lips and the tongue [3,5,18,23].…”

Section: Discussionmentioning

confidence: 99%

Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases

Capodiferro

Ingravallo

Limongelli

et al. 2020

JCM

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Aims: To report on the clinico-pathological features of a series of 14 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth. Materials and methods: All mucoepidermoid carcinomas diagnosed in the period 1990–2012 were retrieved; the original histological preparations were reviewed to confirm the diagnosis and from selected cases, showing exclusive intra-cystic neoplastic components, additional sections were cut at three subsequent 200 m intervals and stained with Hematoxylin–Eosin, PAS, Mucicarmine and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Additionally, pertinent findings collected from the clinical charts and follow-up data were analyzed. Results: We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of five years. The neoplasms were located in the hard palate (nine cases), the soft palate (two), the cheek (two) and the retromolar trigone (one). In all instances, histological examination revealed the presence of a single cystic space, containing clusters of columnar, intermediate, epidermoid, clear and mucous-producing cells, the latter exhibiting distinct intra-cytoplasmic mucin production, as confirmed by PAS, Mucicarmine and Alcian Blue stains. The cysts were entirely circumscribed by fibrous connective tissue, and no solid areas or infiltrating tumor cell clusters were detected. Conservative surgical resection was performed in all cases, and no recurrences or nodal metastases were observed during follow up. Conclusions: Mucoepidermoid carcinomas showing prominent (>20%) intra-cystic proliferation currently are considered low-grade tumors. In addition, we also unveil the possibility that mucoepidermoid carcinomas, at least in their early growth phase, may display an exclusive intra-cystic component and might be considered as in situ carcinomas, unable to infiltrate adjacent tissues and metastasize.

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Section: Discussionmentioning

confidence: 99%

Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases

Capodiferro

Ingravallo

Limongelli

et al. 2020

JCM

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“…Nevertheless, high-grade MEC has to be differentiated from other high-grade carcinomas, including salivary duct carcinoma, adenocarcinoma not otherwise specified, squamous cell carcinoma, and epithelial-myoepithelial carcinoma. These neoplasms are very rare in paediatric age, and only squamous cell carcinoma and epithelial-myoepithelial carcinoma have been reported [4, 27, 42]. However, in our series, an accurate preoperative cytological diagnosis was rendered in all the 5 cases, and subsequently confirmed by the histological examination of the surgical samples, with a diagnostic sensitivity and specificity of 100%.…”

Section: Discussionmentioning

confidence: 53%

“…In our previous series, FNAC of paediatric SGTs demonstrated high diagnostic performance, with a sensitivity of 92% and a specificity of 86% [2]. Regarding MEC in particular, cytological diagnostic features were generally described in adult patients series [25, 26], while few cases with cytological diagnosis were reported in paediatric population [26, 27]. The cytological characteristics of MEC were firstly described by Mavec et al [28] and subsequently by Persson and Zettergren, [29] describing a total of 4 cases of adult MECs.…”

Section: Introductionmentioning

confidence: 99%

Fine-Needle Aspiration Cytology Is an Effective Diagnostic Tool in Paediatric Patients with Mucoepidermoid Carcinoma as Secondary Neoplasm

et al. 2020

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Background: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumour in paediatric population, accounting for 16% of all cases. Patients affected by a previous solid or leukaemic neoplasm during their childhood may develop a second different tumour during the follow-up. In this setting, salivary gland MEC is relatively frequent, accounting for 6% of the second neoplasms in paediatric patients. Consequently, the occurrence of salivary gland nodules in paediatric patients with a previous neoplasm should be considered an event with a high risk of malignancy that poses peculiar diagnostic challenges. Summary: This study was designed to define clinical and instrumental findings and morphological features of MEC on fine-needle aspiration cytology (FNAC) samples in paediatric patients with and without a previous neoplasm. Five patients under 19 years are included in this series. FNAC was performed in all patients on a parotid nodule. We have identified 2 groups of patients: (a) 2 cases with previous history of malignancy (acute lymphoblastic leukaemia and Hodgkin lymphoma) and (b) 3 cases without previous malignant neoplasms. In all cases, a final diagnosis of MEC was rendered. Key Messages: MEC may occur as a second malignancy in paediatric patients. FNAC is certainly a valid and accurate diagnostic tool for this type of neoplasm, even in the paediatric age, allowing the correct management of the patients.

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“…Among such patients there were 3 males and 11 females, with a median age of 36.8 years; 9 MECs involved the hard palate, 2 cases the soft palate, 2 the cheek mucosa and 1 case the retromolar trigone. In all instances, the neoplasms appeared as intra-oral nodules ( MEC is the most common malignant tumor of the salivary glands (12-29%) in children and young adults 9,26,29,30 and, according to some authors, the most common malignancy in minor salivary glands: [8][9][10][11][12][13]20 its peak of incidence is between the third and sixth decade but it is one of the most salivary malignancies that may occur in children and adolescent under 20 years of age with predilection for women. 26,29,30 As confirmed by the results of the present study, the palate remains the most commonly involved site by MECs occurring in minor salivary glands, while they less frequently occur in the retromolar area, the floor of the mouth, the buccal mucosa, the lips and the tongue.…”

Section: Introductionmentioning

confidence: 99%

“…In all instances, the neoplasms appeared as intra-oral nodules ( MEC is the most common malignant tumor of the salivary glands (12-29%) in children and young adults 9,26,29,30 and, according to some authors, the most common malignancy in minor salivary glands: [8][9][10][11][12][13]20 its peak of incidence is between the third and sixth decade but it is one of the most salivary malignancies that may occur in children and adolescent under 20 years of age with predilection for women. 26,29,30 As confirmed by the results of the present study, the palate remains the most commonly involved site by MECs occurring in minor salivary glands, while they less frequently occur in the retromolar area, the floor of the mouth, the buccal mucosa, the lips and the tongue. 3,5,18,24 The cases reported herewith showed the distinctive morphological features of "classical" MEC 5,31,32 i.e., an epithelial tumor composed by intermediate, epidermoid, mucous-producing and clear cells, arranged in irregular clusters of variable size but, at variance with conventional MEC, no foci of stromal invasion were detected and the neoplastic proliferation manifested an exclusive intracystic growth.…”

Section: Introductionmentioning

confidence: 99%

<strong>Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases</strong>

Capodiferro

Ingravallo

Limongelli

et al. 2020

Preprint

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Aims:To report on the clinico-pathological features of a series of 12 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth.Methods and methods: All mucoepidermoid carcinomas diagnosed in the period 1990-2012 were retrieved, the original histological preparations were reviewed to confirm the diagnosis, and from selected cases, showing exclusive intra-cystic neoplastic component, additional sections were cut Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 8 April 2020 at 3 subsequent 200 m intervals and stained with Hematoxylin-Eosin, PAS and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Also, pertinent findings collected from the clinical charts and follow-up data were analyzed. Results:We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of 5 years. The neosplasm were located in the hard palate (9 cases), the soft palate (2), the cheeck (2) and the retromolar trigone (1). In all instances histological examination was revealed the presence of a single cystic space, containing clusters of columnar, intermediate, epidermoid, clear and mucous-producing cells, the latter exhibiting distinct intracytoplasmic mucin production, as confirmed by PAS and Alcian Blue stains. The cysts were entirely circumscribed by fibrous connective tissue and no solid areas or infiltrating tumour clusters were detected. Conservative surgical resection was performed in all cases and no recurrences or nodal metastases were observed during the follow up period. Conclusions:Mucoepidermoid carcinomas showing prominent (>20%) intra-cystic proliferation currently are considered low-grade tumours. In addition, we also unveil the possibility that mucoepidermoid carcinomas, at least in their early growth phase, may display an exclusive intracystic fashion and might be considered as in situ carcinomas, unable to infiltrate adjacent tissues or metastasize.KEY WORDS: salivary glands, minor salivary glands, salivary gland carcinoma, mucoepidermoid carcinoma, in situ carcinoma, intra-cystic carcinoma Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 8 April 2020

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Mucoepidermoid carcinoma of the head and neck in children

Cited by 21 publications

References 31 publications

Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases

Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases

Fine-Needle Aspiration Cytology Is an Effective Diagnostic Tool in Paediatric Patients with Mucoepidermoid Carcinoma as Secondary Neoplasm

<strong>Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases</strong>

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