Mucoepidermoid carcinoma of the larynx: Case report and review of the literature

Kmeid, Elio; Romanos, Bassam; Chammas, Salim

doi:10.1016/j.xocr.2022.100453

Cited by 1 publication

(3 citation statements)

References 17 publications

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“…Only in a small number of studies a follow-up of 5 or more years (in some of the patients) is reported. 23,25,31,34,37 The Murad MH assessment tool was employed to evaluate the reliability and the quality of the included case series and case reports. Our assessment tool indicated that 11 studies have low risk of bias, 4 studies have unclear risk of bias, and 10 studies have high risk of bias.…”

Section: Resultsmentioning

confidence: 99%

“…Plenty of studies reported brief follow‐up times (up to 1 year) 13,17,19,27,36 or no follow‐up information 12,19,20,22,26,28,30 making difficult to evaluate the long‐term impact of disease on patients. Only in a small number of studies a follow‐up of 5 or more years (in some of the patients) is reported 23,25,31,34,37 …”

Section: Resultsmentioning

confidence: 99%

“…It was a glottic, T1bN0M0, low‐grade MEC that did not recurrent in the 6‐year follow‐up 23 . In 2022, Kmeid et al presented an almost identical case that responded well and had no recurrence in the third year of his follow‐up 37 . Although promising, these data are not conclusive evidence and need further validation with large, randomized studies.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Behavior of the Mucoepidermoid Carcinoma of the Larynx—A Scoping Review

Poutoglidis,

Forozidou,

Fyrmpas

et al. 2023

The Laryngoscope

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ObjectiveMucoepidermoid carcinomas (MEC) of the larynx account for less than 1% of all laryngeal tumors. The unique features and clinical behavior of these rare entities remain unknown. To fill this knowledge gap, we performed a scoping review of every reported case of laryngeal MEC to study the clinical behavior and the treatment modalities in this rare entity.Review MethodsWe followed the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses extension for scoping reviews (PRISMA‐ScR) statement.Data SourcesMedLine, Google Scholar, and Science Direct databases were searched to identify eligible studies.ResultsWe concluded with 25 studies and overall 66 cases. Our study revealed that the average age of cases was 55.7 years, and the range was from 12 to 81 years, with younger onset in females. Supraglottic (60%) is the most common subsite of laryngeal MEC s followed by glottis (27.3%). Supraglottic carcinomas frequently present with metastatic neck disease at the time of the initial diagnosis and require more extensive surgical approaches. Surgery with negative surgical margins seems to be the cornerstone in the treatment of MEC. Radiation therapy has not been tested widely as monotherapy but is considered a useful adjuvant modality.ConclusionThis study suggests that negative surgical margins seem to be associated to higher disease control rate and that high‐grade supraglottic cases likely benefit from addressing neck disease simultaneously.Level of EvidenceNA Laryngoscope, 2023

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