Mucoepidermoid penile carcinoma: clinical, histologic, and immunohistochemical characterization of an uncommon neoplasm

Froehner, Michael; Schöbl, R; Wirth, Manfred P.

doi:10.1016/s0090-4295(00)00530-6

Cited by 13 publications

(21 citation statements)

References 10 publications

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“…3 The most important consideration in the differential diagnosis of adenosquamous carcinoma is mucoepidermoid carcinoma. 6,7,8 Both types of carcinoma present glandular elements, but in adenosquamous carcinoma, the squamous component predominates and there is a true glandular differentiation. 7,8 In many instances, the terms "adenosquamous" and "mucoepidermoid carcinoma" have been used as synonyms.…”

Section: Discussionmentioning

confidence: 99%

“…6,7,8 Both types of carcinoma present glandular elements, but in adenosquamous carcinoma, the squamous component predominates and there is a true glandular differentiation. 7,8 In many instances, the terms "adenosquamous" and "mucoepidermoid carcinoma" have been used as synonyms. 5,8 However, these tumors may have different clinical courses and prognoses.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 In many instances, the terms "adenosquamous" and "mucoepidermoid carcinoma" have been used as synonyms. 5,8 However, these tumors may have different clinical courses and prognoses. 7,8 A poor prognosis has been attributed to both variants 7,8 but, similarly to skin cancer, adenosquamous carcinoma appears to have a more aggressive course 8 (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…5,8 However, these tumors may have different clinical courses and prognoses. 7,8 A poor prognosis has been attributed to both variants 7,8 but, similarly to skin cancer, adenosquamous carcinoma appears to have a more aggressive course 8 (Table 1). Other tumors that are considerations in the differential diagnosis are adenoid or pseudoglandular SCC, urethral carcinomas, and metastatic lesions to the penis.…”

Section: Discussionmentioning

confidence: 99%

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Adenosquamous Carcinoma of the Penis

Romero

Castro

Garcia

et al. 2006

Clinics

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Adenosquamous Carcinoma of the Penis

Romero

Castro

Garcia

et al. 2006

Clinics

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“…Squamous cell carcinoma (SCC) accounts for 95% of the histological types of penile cancer, 1 but other rarer types, such as mucoepidermoid carcinoma (MC), may also affect the penis. The origin of SCC of the penis is usually the scamous epithelial surface, while the MC of the penis does not have a known source.…”

Section: Introductionmentioning

confidence: 99%

Mucoepidermoid carcinoma of penis: Case report and review

Costa¹,

Sugita²,

Vilela³

et al. 2015

CUAJ

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We describe the fifth case of mucoepidermoid carcinoma. The patient had penile ulcer with bilateral inguinal and pelvic lymphadenopathy and underwent total penectomy. After antibiotic therapy, the patient began outpatient chemotherapy, but the treatment was discontinued due to his intolerance. The patient died due to infectious complications of the inguinal lymphatic fistula 7 months after the histological diagnosis. Notably, the periurethral area was involved in the anatomopathological evaluation of the excised penis. The penile mucoepidermoid carcinoma was aggressive and the perimeatal region was involved. This case helps demystify the origins and prognosis of this rare case. More reports documenting patient characteristics and their evolution with penile mucoepidermoid carcinoma are needed. IntroductionSquamous cell carcinoma (SCC) accounts for 95% of the histological types of penile cancer, 1 but other rarer types, such as mucoepidermoid carcinoma (MC), may also affect the penis. The origin of SCC of the penis is usually the scamous epithelial surface, while the MC of the penis does not have a known source. Glans cancer frequently arises from the periurethral glands of Littré, bulbar Cowper, and sweat glands. 2-4The prognosis of penile cancer in its early stages is good. The survival and the risk of metastasis of SCC of the penis are different according to histologic variants. The histological subtypes verrucous, papillary, and verrucoid are low risk, and the usual SCC is intermediate risk and the sarcomatoid or basaloid variants are high risk.5 Although non-SCC types are not classified in risk, their behaviour and prognosis can be ascertained. Basal cell carcinomas are highly curable and have a low potential for metastasis; they are prone to local recurrence, but metastases are rare and the melanomas are aggressive but can be cured if treated early. 6 The adenosquamous carcinoma is locally aggressive, with high histologic grade differentiation at diagnosis and a high rate of lymphovascular invasion.7 It well-known that, generally, metastatic tumours to the penis have a poor prognosis.6 MC of the penis is extremely rare and has a pattern of behavior has not yet been established.We used 4 databases for our analysis (PubMed, Portal de Periódicos da Capes, Lilacs, and SciELO) on February 17, 2014. We searched without filtres and with the intersection of the following MESH terms: "Penile neoplasms" versus "Mucoepidermoid Tumour" or "Carcinoma, Mucoepidermoid" and "Penis" versus "Mucoepidermoid Tumor" or "Carcinoma, Mucoepidermoid." In doing so, we identified 4 cases of primary penile MC (Table 1). This is the fifth case, which adds to the literature and helps delineate the behaviour and origin of this disease. Case reportOur patient, a 47-year-old had a wound on the penis after circumcision. He sought medical attention 45 days after lesion onset; it was a single lesion, showing ulcerative and infiltrative aspect, about 7 cm, occupying the entire glans and about four-fifths of the distal penile shaft (Fig...

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