Mucoepidermoid tumors of salivary glands

Abstract

Mucoepidermoid tumors of salivary glands are relative rare and it has often been difficult to correlate the patologic features and clinical aspects. The literature recommends long term follow‐up studies. The object of the present study was therefore to follow this recommendation. The clinico‐pathological features of 39 mucoepidermoid tumors are presented. The material was retrieved from the files of the pathological institute, Rigshospitalet, Copenhagen, during the period 1941–75. All patients, 24 males, 15 females, were followed for a minimum of 5 years. The lesions were classified into low grade (13 cases), intermediate grade (14 cases) and high grade (12 cases). The corresponding 5, 10 and 15 years cumulative survival rates were 92%, 92%, 92% for low grade, 47.4%, 47.4%, 35.5% for intermediate grade and 0%, 0%, 0% for high grade tumors. Thus we found a close correlation between pathology and clinical course. Furthermore, a 5 year observation period appeared an acceptable approach, because 17 of the 18 patients who succumbed of the disease, did so within 4 years following surgery. We consider all grades of mucoepidermoid tumors to be potential malignant. In our study one patient with a low grade tumor died of the disease.

Primary cutaneous mucoepidermoid carcinoma: report of a case

“…They are rare in other locations but have been described in bronchial mucosa (2) and ceruminous glands of the ear. In the skin, however, primary mucoepidermoid carcinomas are exceedingly rare (1,(3)(4)(5). We describe in this report a primary cutaneous mucoepidermoid carcinoma of the right ear.…”

“…Mucoepidermoid carcinomas are the most common malignant neoplasms arising in major salivary glands (1). They are rare in other locations but have been described in bronchial mucosa (2) and ceruminous glands of the ear.…”

Langzeitbeobachtungen von Patienten mit Mukoepidermoidtumoren im Kopf-Hals-Bereich

“…Spiro et al [9] fanden bessere Überlebensraten bei jungen Patienten und bei Frauen, was sie ebenfalls darauf zurückführten, dass in dieser Gruppe die Inzidenz kleinerer hochdifferenzierter Tumo ren am höchsten ist. Bezüglich der Überlebensraten stimmten unsere Ergebnisse mit den in der jüngeren Lite ratur angegebenen im wesentlichen überein [6][7][8]12], Die Vergleichbarkeit der Ergebnisse ist jedoch insofern einge schränkt, als einige Autoren als dritten zusätzlichen Malignitätsgrad den intermediäten Typ des Mukoepider moidtumors unterscheiden. Tabelle 3 gibt einen Über blick über die Ergebnisse verschiedener Autoren.…”

“…Bhaskar und Bernier [ 13] berichteten, dass alle Rezidive innerhalb der ersten 5 Jahre auftraten. Jacobsson et al [5] [7] 92.0 47.4 0 Evans, 1984 [8] 100,0? etwa 65 Spiro et al, 1978 [9] 92.0 49 Jacobsson et al.…”

Tumour growth fraction and apoptosis in salivary gland acinic cell carcinomas. Prognostic implications of Ki-67 andbcl-2 expression and ofin situ end labelling (TUNEL)

“…Numerous studies have been performed seeking for prognostic factors; [5][6][7][8][9][10][11] cell proliferation, in particular, has been extensively studied, although it does not correlate well with the overall tumour growth rate. 12 Two recent studies of cell proliferation in ACC and mucoepidermoid carcinoma using the MIB-1 antibody against the cell cycle-associated Ki-67 antigen have revealed a correlation with prognosis, 13,14 but estimation of the net tumour growth might give additional useful information.…”