Mucopurulent Cervicitis andMycoplasma genitalium

Abstract

Many cases of mucopurulent cervicitis (MPC) are idiopathic and cannot be attributed to the known cervical pathogens Neisseria gonorrhoeae, Chlamydia trachomatis, or herpes simplex virus. Because Mycoplasma genitalium is associated with nongonoccocal urethritis in men, its role in MPC, the corresponding syndrome in women, was investigated. Archived cervical specimens from women recruited in the Harborview Sexually Transmitted Disease Clinic in Seattle from 1984 to 1986 were tested, using polymerase chain reaction, in a study that identified other causes of and risk factors for MPC. M. genitalium was detected in 50 (7.0%) of 719 women. Young age, multiple recent partners, prior miscarriage, smoking, menstrual cycle, and douching were positively associated with M. genitalium, whereas bacterial vaginosis and cunnilingus were negatively associated. After adjustment for age, phase of menstrual cycle, and presence of known cervical pathogens, women with M. genitalium had a 3.3-fold greater risk (95% confidence interval, 1.7-6.4) of MPC, which suggests that this organism may be a cause of MPC.

Mycoplasma genitalium among Adolescent Women and their Partners

“…The implications for management of M. genitalium and C. trachomatis infections warrant further study into this association. While others [10] have not shown an association between these two organisms, the difference in study findings may be explained by our sample population of adolescents in whom STI infection is highly prevalent.…”

“…Point prevalence ranged from 0.8-4.1%. Previous cross-sectional studies that included some adolescents found a point prevalence between 3.5-7% [10,17,18]. The difference in point prevalence found here may be attributable to the target population for this project as the young women were not recruited from STD or family planning clinics.…”

“…The difference in point prevalence found here may be attributable to the target population for this project as the young women were not recruited from STD or family planning clinics. In one study, the average age among M. genitalium infected women was 20 years, compared to 23 years among uninfected women [10]. This suggests that risk for M. genitalium detection, as with other STI, is increased for adolescent women.…”

“…M. genitalium is associated with NGU, mucopurulent cervicitis, and other reproductive tract infections [8][9][10][11].…”

Aplicación de método molecular en la detección de Mycoplasma genitalium en hombres y en mujeres embarazadas

“…Varios estudios efectuados mediante RPC han detectado M. genitalium en 15 a 25% de hombres con UNG [5][6][7][8][9] . En la mujer, M. genitalium ha sido asociado con cervicitis 5,[10][11] , enfermedad inflama-muestras clínicas fueron obtenidas con tórula fina de algodón e inmediatamente inoculadas en medio de transporte Stuart y en 1,5 ml de buffer de transporte sacarosa fosfato (buffer 2SP). Mujeres sexualmente activas: se obtuvieron dos muestras de secreción vaginal de 40 mujeres atendidas consecutivamente en el Departamento de Alto Riesgo Obstétrico (DARO) del Hospital San Juan de Dios.…”