Mucormicosis cutánea primaria por Rhizopus arrhizus en una niña de 8 años

Albízuri-Prado, María Fátima; Sánchez-Orta, A.; Rodríguez-Bandera, A.I.; Feito-Rodríguez, M.

doi:10.1016/j.ad.2017.07.020

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…Authors from different parts of the world (India, Spain and the United States) have described cases of cutaneous mucormycosis in pediatric patients with various risk factors. In concordance with our case, most of them were with hematological malignancies (Hodgkin lymphoma, acute myeloblastic leukemia, aplastic anemia) or had underwent hematopoietic stem cell transplantation, but the cutaneous infection was presented only by a single focus without spreading to other skin areas and mainly affected the arm or the face [ 6 , 16 , 17 , 18 ]. In addition, trauma to the affected area usually preceded the development of infection.…”

Section: Discussionsupporting

confidence: 87%

“…The cutaneous form of mucormycosis manifests with a red and swollen plaque, which can later ulcerate and necrotize. Blood vessels, subcutaneous layers and muscles may also be affected [ 16 ]. Upon hospitalization, our patient developed new lesions and infiltration in the cubital fossa rapidly increased after starting chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…One of the most severe complications of cutaneous mucormycosis is the hematogenous dissemination of the pathogen, observed mainly in individuals with underlying diseases and various risk factors [ 25 ]. When dissemination occurs, mortality rates may reach up to 94% [ 16 ]. A specific and rarely observed feature of the presented clinical case is that despite the presence of several significant risk factors (young age, acute lymphoblastic leukemia, chemotherapy, neutropenia) and the formation of multiple skin lesions, no dissemination of the pathogen and the involvement of the internal organs and central nervous system had developed.…”

Section: Discussionmentioning

confidence: 99%

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A Case of Primary Multifocal Cutaneous Mucormycosis in a Pediatric Patient with Newly Diagnosed Acute Lymphoblastic Leukemia

et al. 2023

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Mucormycosis, caused by the widespread molds of the Mucorales order, is an insidious infection that manifests in different clinical forms. Even the most benign form, the cutaneous mucormycosis, can present with severe complications and a fatal outcome in patients with a suppressed immune system and underlining comorbidities. We present a rare case of a proven primary multifocal cutaneous mucormycosis in a child with newly diagnosed acute leukemia without multiorgan dissemination. Various laboratory techniques (histopathological, cultural and molecular-genetic) were used to detect and confirm the diagnosis. Etiological therapy (liposomal amphotericin B, 5 mg/kg) combined with surgical intervention were used to manage the infection. The case shows that a rapid and complex diagnostic approach is of crucial importance for the timely initiation of adequate therapy, as well as for the successful management of this life-threatening fungal infection.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Case of Primary Multifocal Cutaneous Mucormycosis in a Pediatric Patient with Newly Diagnosed Acute Lymphoblastic Leukemia

et al. 2023

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“…Primary cutaneous mucormycosis (PCM) represents 10%–22% of all cases and is often preceded by trauma. It commonly presents in immunocompetent hosts; however, it also has been reported in immunocompromised patients [3]. We present a case of PCM in a patient with bone marrow failure secondary to paroxysmal nocturnal haemoglobinuria (PNH).…”

Section: Introductionmentioning

confidence: 99%

Primary cutaneous mucormycosis due to Rhizopus arrhizus in an immunosuppressed patient with paroxysmal nocturnal haemoglobinuria

Osorio‐Aragón,

Toussaint‐Caire,

Guzmán‐Bucio

et al. 2023

Tropical Med Int Health

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Objective We present a case of primary cutaneous mucormycosis in a patient with bone marrow failure secondary to paroxysmal nocturnal haemoglobinuria (PNH). Clinical case A 60‐year‐old male patient with a history of PNH, complicated to a severe aplastic anaemia, presented to the emergency department complaining of papules on the lower limbs that rapidly turned into necrotic plaques within 2 months. Histopathological examination showed granulomatous and suppurative dermatitis with tissue necrosis and the presence of non‐septate hyphae. Molecular identification was achieved by amplification and sequencing of the 18S‐ITS1‐5.8S‐ITS2‐28S rRNA region using the polymerase chain reaction. The sequence showed 100% identity with Rhizopus arrhizus. The patient received treatment with liposomal amphotericin B and surgical debridement. Nonetheless, the patient suffered from severe low red blood cells and platelets and also underwent septic shock; he died 6 days after admission to the hospital. Conclusion Mucormycosis in the setting of immunosuppression is challenging. Upon suspicion of a diagnosis, immediate treatment is required. Adjunctive therapies may be considered; however, the case fatality rate remains high.

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Promotion of Metabolite Synthesis in Isaria cicadae, a Dominant Species in the Cicada Flower Microbiota, by Cicada Pupae

Chunyu

Lü

Luo

et al. 2019

J. Agric. Food Chem.

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Cicada flowers, which are edible and medicinal mushrooms, are the fruiting bodies of Isaria cicadae, a fungus that is parasitic on the larvae of cicada pupae. We hypothesize that host factors might possess stimulatory activity on metabolite synthesis in Isaria cicadae. Here, we first compared the microbial community structures of different wild cicada flowers across geographical regions, compartments, and growth stages via high-throughput sequencing. Isaria cicadae TZC-3, an isolate of the most abundant operational taxonomic unit (OTU6782) in all the fungal communities, was isolated from wild cicada flowers. Furthermore, the effects of cicada pupae on metabolite synthesis in Isaria cicadae TZC-3 were studied in submerged culture. The contents of intercellular polysaccharides, adenosine, N6-(2-hydroxyethyl)-adenosine, free amino acids, and hydrolyzed monosaccharides in the mycelia cultured with cicada pupa powder (4%) were significantly increased as compared with the contents in the control group. This indicates that a cicada pupa can act as an elicitor for metabolite synthesis in Isaria cicadae.

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Mucormicosis cutánea primaria por Rhizopus arrhizus en una niña de 8 años

Cited by 4 publications

References 12 publications

A Case of Primary Multifocal Cutaneous Mucormycosis in a Pediatric Patient with Newly Diagnosed Acute Lymphoblastic Leukemia

A Case of Primary Multifocal Cutaneous Mucormycosis in a Pediatric Patient with Newly Diagnosed Acute Lymphoblastic Leukemia

Primary cutaneous mucormycosis due to Rhizopus arrhizus in an immunosuppressed patient with paroxysmal nocturnal haemoglobinuria

Promotion of Metabolite Synthesis in Isaria cicadae, a Dominant Species in the Cicada Flower Microbiota, by Cicada Pupae

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