Mucormycosis: A triple burden in patients with diabetes during COVID-19 Pandemic

Atypical presentations of fungal osteomyelitis during post COVID-19 outbreak – Case series

“…Based on the system it involves, it is classified as: Rhinocerebral Mucormycosis (RCM), Cutaneous, Pulmonary, Gastrointestinal, Renal, and Hepatic Mucormycosis [8] . The sinuses (39%), pulmonary (24%), disseminated (23%), skin and soft tissue infection (19%) are the most prevalent sites of mucormycosis infections in India [9] . The classical signs and symptoms of RCM as described by Smith and Krichner (1950) include [10] : soft peri-nasal or peri-orbital swelling with discoloration and induration, ptosis of the eyeball and complete ophthalmoplegia, black necrotic turbinates, blood-tinged nasal discharge and ipsilateral facial pain, and multiple cranial nerve palsies [11] .…”

“…According to Code Mucor, Posaconazole oral is used as step down therapy for 3-6 months [4] . It’s safety and efficacy was studied in Rhino-orbito-cerebral Mucormycosis patients of South India, the study reported no morbidity and disease clearance in about 66.6% of patients [9] .…”

Eye and SARS-CoV-2 in 2022

“…These infections are classically associated with immunocompromised and diabetic patients. Patients with severe COviD-19 often have comorbidities that may predispose them to mucormycosis, and the use of systemic corticosteroids as standard therapy likely further contributes to its development [42][43][44][45].…”

Mucormycosis (black fungus) infection and misuse of corticosteroids in COVID 19 patients in Syria

“…Mucormycosis (also known as zygomycosis) is a serious and rare fungal infection, which observed in a number of COVID-19 cases recently. Mucormycosis is found throughout the environment, mostly in the soil [ 1 , 2 ]. Mucormycosis is an aggressive infection that usually affects immunocompromised conditions, poorly managed diabetics, and COVID-19 patients who are on steroid therapy on a long-term basis such as dexamethasone [ 3 , 4 ].…”

“…Generally, Mucormycosis spores are transmitted in several ways, especially by inhaling from the air to our sinuses, causing many symptoms like fever, headache, nasal congestion, and the most important sign is “black lesions” that quickly become more severe. Also, it may damage the lung, skin, digestive system, brain, and up to death [ 1 , 2 ]. For the serious complications of mucormycosis infection, we would highlight in this paper, the relationship between this infection and the misuse of steroids in our country.…”