Mucormycosis and acute kidney injury

Gupta, Aarushi

doi:10.5812/nephropathol.8111

Cited by 21 publications

(15 citation statements)

References 29 publications

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“…Renal zygomycosis has been described mainly from India and presents as a febrile illness with invasion of renal vessels leading to tissue infarction. 12,95,96 When bilateral (Fig 3), it causes irreversible kidney failure and carries high mortality despite antifungal therapy and tissue debridement.…”

Section: Fungal Infectionsmentioning

confidence: 99%

CKD and Infectious Diseases in Asia Pacific: Challenges and Opportunities

Jha

Prasad

2016

American Journal of Kidney Diseases

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The exact number of patients with chronic kidney disease (CKD) in Asia Pacific is uncertain. In numeric terms, the region is home to the largest population of patients with untreated chronic kidney failure. The climatic, geographic, social, cultural, economic, and environmental diversity within this region is higher than in any other part of the world. Large parts of the region face a climate-related burden of infectious diseases. Infections contribute to the development and progression of CKD and complicate the course of patients with pre-existing CKD (especially those on dialysis therapy or who are immunosuppressed), increase the cost of CKD care, and contribute to mortality and morbidity. Kidney involvement is a feature of several infectious diseases prevalent in Asia Pacific. Examples include malaria, leptospirosis, scrub typhus, tuberculosis, hepatitis B and C virus, dengue hemorrhagic fever, and Hantaan virus infections. The contribution of infection-associated acute kidney injury to the overall burden of CKD has not been evaluated systematically. Research is needed to quantify the impact of infections on kidney health by undertaking prospective studies. Nephrologists need to work with infectious disease research groups and government infection surveillance and control programs.

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Section: Fungal Infectionsmentioning

confidence: 99%

CKD and Infectious Diseases in Asia Pacific: Challenges and Opportunities

Jha

Prasad

2016

American Journal of Kidney Diseases

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“…Early processing for histopathology of the aspirated material may yield a diagnosis and treatment would entail early debridement and long term Amphotericin. In our case timely percutaneous aspiration yielded the histological diagnosis with the characteristic finding of broad hyphae which branch irregularly at right angles [9]. Our patient had radiological features to suggest involvement of right kidney; with fat stranding, appearance of wedge shaped area in the inferior polar region and a delayed nephrostogram; a thorough search for a systemic source was negative.…”

Section: Introductionmentioning

confidence: 54%

“…Local instillation of Liposomal Amphotericin was successful in those cases where there was only pelviclyceal system involvement [7,8]. In a patient with clinical diagnosis of acute pyelonephritis and radiological features suggestive of a focal abscess in the form of wedge shaped areas appearing like infarcts, delayed contrast uptake with negative cultures, mucormycosis should be thought of early on [9]. Early processing for histopathology of the aspirated material may yield a diagnosis and treatment would entail early debridement and long term Amphotericin.…”

Section: Introductionmentioning

confidence: 99%

Hyponatremia in COVID-19 Infection - Possible Causal Factors and Management

Flor¹,

Valga²,

Alexander³

et al. 2020

J Clin Nephrol Ren Care

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since four days; followed by pain over the right flank, which radiated to the anterior abdomen. There was no dysuria, haematuria, lithuria, gravelurea; or history of passage of any fleshy material in the urine. Furthermore, there was no history of reduction in the urine output nor similar complaints in the past. He looked clinically unwell. He had tachycardia with a pulse rate of 120/minute, with a normal blood pressure and respiratory rate. His temperature was 38 °C, weight was 68 kg and a BMI of 22.6 kg/m 2. A systemic examination revealed tenderness and guarding in the right upper quadrant. A clinical diagnosis of acute right sided pyelonephritis was considered. Investigations revealed a haemoglobin of 13.1 gm/dL (normal range: 12 gm/ dL to 16 gm/dL); and a white cell count of 15000/mm 3 (normal range: 4000/mm 3 to 11000/mm 3), with polymorphs of 73%, lymphocytes of 22% and eosinophils of 03%. Urine analysis showed the urine to be positive for leucocyte esterase. BUN was 19 mg/dL (normal range 15 mg/dL to 40 mg/dL), serum creatinine 1.02 mg/dL (normal range 0.6 mg/dL to 1.4 mg/dl), blood sugar fasting and post-prandial were 80 mg/dL and 103 mg/ dL respectively, serum bilirubin was 0.4 mg/dL, serum albumin 4.2 gm/dL, serum AST/ALT was 19/22 IU/L. HIV, HBsAg, anti-HCV were non-reactive. His blood, urine were sterile, chest X-ray was normal, 2D echocardiography did not reveal any vegetation, serum procalcitonin was 0.6; and his serum beta galactomannan was 0.34 (Normal < 0.50). Ultrasound of the kidneys revealed an enlarged right kidney and a hypoechoic lesion in the inferior pole of right kidney. Contrast-enhanced computerised tomography (CECT) of the kidney, ureter and bladder (KUB) conducted on day two, revealed

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“…Our case of renal mucormycosis had a rare presentation of unilateral hydronephrosis and pyelonephritis. Without early diagnosis and immediate aggressive treatment, renal mucormycosis is almost universally fatal [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Renal Mucormycosis: Post-COVID-19 Infection Presenting as Unilateral Hydronephrosis in a Young Immunocompetent Male

Nepali

Shrivastav

Shah

2022

Case Reports in Nephrology

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Mucormycosis is a rare invasive fungal infection with a high mortality rate caused by members of the family Mucoraceae. It mainly affects immunocompromised hosts such as poorly controlled diabetes mellitus, previous solid organ transplant, high-dose steroids, and hematologic malignancy. The most common sites of the disease are rhinocerebral, the skin, the lungs, and the gastrointestinal tract. In this era of COVID-19 infection, there has been a significant rise in invasive mucormycosis predominantly reported from southeast. We present a case of isolated renal mucormycosis in an apparently healthy individual with post-COVID-19 infection presenting as unilateral hydronephrosis. Timely identifying at-risk populations and having a high degree of suspicion with involvement of multidisciplinary teams are of utmost importance to diagnose and treat a rare and fatal infection. Even if there is a long history, antifungal drugs and removal of the source can result in a good outcome.

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Mucormycosis and acute kidney injury

Cited by 21 publications

References 29 publications

CKD and Infectious Diseases in Asia Pacific: Challenges and Opportunities

CKD and Infectious Diseases in Asia Pacific: Challenges and Opportunities

Hyponatremia in COVID-19 Infection - Possible Causal Factors and Management

Renal Mucormycosis: Post-COVID-19 Infection Presenting as Unilateral Hydronephrosis in a Young Immunocompetent Male

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