Mucormycosis and Myiasis in Uncontrolled Diabetes: A Double Whammy

Toshniwal, Om Prakash D; Sm, Ravi Prakash; Gill, Navneet; Verma, Sankalp; Kailasam, S

doi:10.5005/jp-journals-10011-1112

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…9 Three common groups of mucorales cause mucormycosis in humans namely, rhizopus, rhizomucor and absidi, with rhizopus accounting for 90% of cases involving the head and neck region. 10 Mucorales are cultured from the oral cavity, nasal passage and pharynx of healthy individuals without any clinical signs of infection. Invariably mucormycosis manifests when the organisms affect the immunocompromised patients.…”

Section: Mucormycosis Commonly Known As Black Fungus Hasmentioning

confidence: 99%

Review on mucormycosis in the oro-facial region: an overview

Sonawane

Ahire

Saha

2021

Int J Community Med Public Health

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The study aims to identify the clinical manifestation of mucormycosis in the oro-facial region to distinguish the role of meticulous intraoral examination for early and timely diagnosis based on the review of reported cases, to propose the role of diabetes mellitus as a predisposing risk factor for mucormycosis in the oro-facial region, to propose the association of traumatic incidents like tooth extraction as a risk factor for mucormycosis in immune-compromised individuals and to perceive the use of amphotericin-B in its treatment. A systematic review was conducted on an electronic database, Google Scholar to analyze the existing data for the clinical manifestation of mucormycosis in the orofacial region. Out of the existing literature on this topic for various timelines, a period of 10 years from 2011 to 2021 was selected for the study. The sample size was calculated taking into consideration the 99.99% confidence interval. The data was extracted from these relevant articles in Microsoft Excel, showing remarkable conclusions. Mucormycosis does not show stereotypical clinical manifestations and thus the diagnosis of mucormycosis has to be confirmed through culture studies and histopathological or radiological ways. Diabetes Mellitus serves as a predisposing factor for mucormycosis in the oro-facial region other than the COVID-19 infection and immune-compromised conditions. Amphotericin-B was a drug of choice for the treatment of mucormycosis by many practitioners. The only hindrance to its usage being its nephrotoxicity.

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Section: Mucormycosis Commonly Known As Black Fungus Hasmentioning

confidence: 99%

Review on mucormycosis in the oro-facial region: an overview

Sonawane

Ahire

Saha

2021

Int J Community Med Public Health

View full text Add to dashboard Cite

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Triple whammy in pandemic: COVID-19, mucormycosis and myiasis

Sood

Bhardwaj

Priya

et al. 2023

IJOAS

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Mucormycosis is a fatal opportunistic fungal infection most commonly seen in immunocompromised individuals. The mortality can vary depending on the extent of the disease, starting in the paranasal sinuses, reaching the orbit, and eventually spreading intracranially. The sudden surge of Mucormycosis along with COVID-19 infections has rightfully been described as an epidemic amidst a pandemic. While the exact etiological factor is still being investigated, uncontrolled diabetes seems to be the most common inciting factor. Mucormycosis being angioinvasive, often leads to thrombus formation in the vessels, which leads to the necrosis of the tissues and bones, most commonly the maxilla. This necrotic tissue forms an ideal culture for various organisms and is a potential source for maggots' infestation. The presence of nasal myiasis further worsens the clinical status of the patients, making them prone to life-threatening complications. Thus, nasal myiasis seems to be an independent prognosticating factor in such cases. Here, we have described two such cases, our approach to management and mortality despite the best possible management.Two cases are being presented of elderly patients with comorbidities of type 2 diabetes mellitus and coronary artery disease. Both patients had a recent onset of COVID-19 and presented with intraorbital and intracranial disease extension along with nasal myiasis. Both patients succumbed to the fulminant pathology despite aggressive management.Mucormycosis, COVID-19 and nasal myiasis combine together to form a fatal triad, which despite early identification and aggressive management, carries a poor prognosis.

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Mucormycosis and Myiasis in Uncontrolled Diabetes: A Double Whammy

Cited by 2 publications

References 12 publications

Review on mucormycosis in the oro-facial region: an overview

Review on mucormycosis in the oro-facial region: an overview

Triple whammy in pandemic: COVID-19, mucormycosis and myiasis

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