Mucormycosis in a Non-Hodgkin Lymphoma Patient Caused by Syncephalastrum racemosum: Case Report and Review of Literature

Rodríguez-Gutiérrez, Georgina; Carrillo-Casas, Erika M.; Arenas, Roberto; García-Méndez, Jorge; Toussaint, Sonia; Moreno-Morales, Mónica E; Schcolnik‐Cabrera, Alejandro; Xicohtencatl‐Cortes, Juan; Hernández‐Castro, Rigoberto

doi:10.1007/s11046-015-9878-1

Cited by 18 publications

(7 citation statements)

References 18 publications

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“…Fungal infections in cancer patients are common. Among the fungal signatures we detected were yeasts like Candida, Geotrichum, Rhodotorula, Trichosporon as well as fungi causing Mucormycosis, Aspergillosis (cutaneous infections) and dermatophytes like Epidermophyton and Trichophyton are commonly known to be associated with cancers (Mays et al, 2006 ; Ansari et al, 2015 ; Banerjee et al, 2015 ; Jung et al, 2015 ; Rodríguez-Gutiérrez et al, 2015 ; Berkovits et al, 2016 ). Also, we detected Fonsecaea infection, which is seen to predispose squamous cell carcinoma development (Azevedo et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Distinct Microbial Signatures Associated With Different Breast Cancer Types

et al. 2018

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A dysbiotic microbiome can potentially contribute to the pathogenesis of many different diseases including cancer. Breast cancer is the second leading cause of cancer death in women. Thus, we investigated the diversity of the microbiome in the four major types of breast cancer: endocrine receptor (ER) positive, triple positive, Her2 positive and triple negative breast cancers. Using a whole genome and transcriptome amplification and a pan-pathogen microarray (PathoChip) strategy, we detected unique and common viral, bacterial, fungal and parasitic signatures for each of the breast cancer types. These were validated by PCR and Sanger sequencing. Hierarchical cluster analysis of the breast cancer samples, based on their detected microbial signatures, showed distinct patterns for the triple negative and triple positive samples, while the ER positive and Her2 positive samples shared similar microbial signatures. These signatures, unique or common to the different breast cancer types, provide a new line of investigation to gain further insights into prognosis, treatment strategies and clinical outcome, as well as better understanding of the role of the micro-organisms in the development and progression of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Distinct Microbial Signatures Associated With Different Breast Cancer Types

et al. 2018

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“…In immunocompromised patients, they have high mortality rates (20%–40% for Candida albicans , 20%–70% for Cryptococus neoformans , and 50%–90% for Aspergillus fumigatus ) [72]. Moreover, new infections due to opportunistic fungi, have emerged recently [73,74,75,76,77]. One of these difficult to treat pathogens is Candida glabrata .…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Antifungal Screening of 2-{[1-(5-Alkyl/arylalkylpyrazin-2-yl)ethylidene]hydrazono}-1,3-thiazolidin-4-ones

Opletalová

Dolezel²,

Kuneš

et al. 2016

Molecules

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Abstract:Two novel thiosemicarbazones and eight novel 2-{[1-(5-alkyl/arylalkylpyrazin-2-yl) ethylidene]hydrazono}-1,3-thiazolidin-4-ones were prepared and tested against a panel of eight fungal strains-Candida albicans ATCC 44859, Candida tropicalis 156, Candida krusei E 28, Candida glabrata 20/I, Trichosporon asahii 1188, Aspergillus fumigatus 231, Lichtheimia corymbifera 272, and Trichophyton interdigitale 445. 1,3-Thiazolidin-4-ones exhibited activity against all strains, the most potent derivative was 2-{[1-(5-butylpyrazin-2-yl)ethylidene]hydrazono}e-1,3-thiazolidin-4-one. Susceptibility of C. glabrata to the studied 1,3-thiazolidin-4-ones (minimum inhibitory concentrations (MICs) were in the range 0.57 to 2.78 mg/L) is of great interest as this opportunistic pathogen is poorly susceptible to azoles and becomes resistant to echinocandins. Antifungal potency of thiosemicarbazones was slightly lower than that of 1,3-thiazolidin-4-ones.

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“…Most cases are reported in immunocompromised individuals ( Table 1 ), e.g. patients on long term steroids, poorly controlled diabetes [ 9 ], or patients with malignancy [ 13 ]. These patients are at high risk of developing an infection [ 7 ] and the combination of compromised immune status with a fungal infection, no doubt has a high mortality.…”

Section: Discussionmentioning

confidence: 99%

“…The most common species of this order are Rhizopus and Mucor [ 3 ] but there are certain rare species such as Syncephalastrum . These are often responsible for opportunistic fungal infections in immunocompromised patients [ 13 ]. Syncephalastrum racemosum , the species of the genus Syncephalastrum species is potentially fatal to human beings.…”

Section: Introductionmentioning

confidence: 99%

Invasive pulmonary infection by Syncephalastrum species: Two case reports and review of literature

Irshad

Nasir

Hashmi

et al. 2020

IDCases

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Background Syncephalastrum species belong to the class Zygomycetes and order Mucorale. These are found in the environment and tropical soil, usually presenting as colonizers and rarely cause human infection. Syncephalastrum racemosum is a species of the genus Syncephalastrum and is the most commonly identified pathogen. Most cases are reported in immunocompromised individuals, such as patients on long term steroids, poorly controlled diabetes, or patients with malignancy. Case presentation We are describing two cases of rare fungal infection by Syncephalastrum species causing invasive pulmonary manifestation. Both patients had compromised immune status and presented with worsening dyspnea to the emergency room. Both had signs and symptoms of bilateral worsening pneumonia evident by chest X-ray showing bilateral pulmonary infiltrates. Syncephalastrum species were isolated from sputum cultures. Deoxycholate amphotericin B was started and the response was monitored. One patient expired while the other improved. Syncephalastrum species belong to class Mucormycosis, rarely causing invasive infection but when they do outcome is potentially fatal. Very few cases are reported worldwide so the clinical course is still unclear. To the best of our knowledge, these are the first two cases to be reported from Pakistan. Conclusions These two cases describe pneumonia as a result of concomitant infection by rare fungal species Syncephalastrum and MRSA in immunocompromised patients. Few cases are reported so limited data is available to understand complete disease implications. Mucormycosis is a therapeutic challenge because of the phylogenetic diversity, un-availability of any serological testing and invasive disease pattern.

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Mucormycosis in a Non-Hodgkin Lymphoma Patient Caused by Syncephalastrum racemosum: Case Report and Review of Literature

Cited by 18 publications

References 18 publications

Distinct Microbial Signatures Associated With Different Breast Cancer Types

Distinct Microbial Signatures Associated With Different Breast Cancer Types

Synthesis and Antifungal Screening of 2-{[1-(5-Alkyl/arylalkylpyrazin-2-yl)ethylidene]hydrazono}-1,3-thiazolidin-4-ones

Invasive pulmonary infection by Syncephalastrum species: Two case reports and review of literature

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