Mucormycosis of the graft in a renal transplant recipient

Successful treatment of mucormycosis in a renal allograft recipient

“…In agreement with the previous reports [7][8][9][10][11][12][13] (Table 1) where all patients presented with pyrexia and graft dysfunction-due to combined graft rejection and mucormycosis; our patient also presented with prolonged pyrexia, graft dysfunction-due to acute rejection-associated with ethimoidal sinus mucormycosis and had survived after combined antifungal and aggressive anti-rejection therapies. The last case reported by Ahmed [14] showed that aggressive anti-rejection therapy with methylprednisolone and antithymocyte globulin seemed to contribute to the unfavorable outcome of his case.…”

“…The favorable outcome in two patients [10,11] could be attributed to the presence of emphysematous pyelonephritis-early diagnosis-in the first patient without receiving anti-rejection therapy. The second patient had acute cellular rejection, which was treated with methylprednisolone only.…”

“…Only one of them who presented with emphysematous graft pyelonephritis in spite that receiving no anti-rejection recovered with antifungal therapy. While Mitwalli et al [10] reported a case of an 18-year-old female, presented with pyrexia, cough, expectoration and graft dysfunction due to acute rejection and mucormycosis. The case was managed by anti-rejection with high-dose steroids and amphotericin B.…”

“…Urology and Nephrology Centre, Mansoura University, Mansoura, Egypt e-mail: ogheith@yahoo.com allograft and five extrarenal) were reported in English literature [2][3][4][5][6][7][8][9][10][11]. In all the 11 cases, the prognosis was poor and the story ended with either death of the patient or removal of the graft.…”

Mucormycosis of the Transplanted Kidney With Renal Papillary Necrosis

“…1 The presentation is usually in rhino-sino-orbital/cerebral, pulmonary, gastrointestinal, or disseminated form. 2 Renal allograft mucormycosis has been described in isolated case reports, [3][4][5] but its association with renal papillary necrosis has not been reported, even though renal papillary necrosis is known to occur in fungal infections of the native kidney, 6,7 as well as transplanted kidney. 8,9 We report one such case and review the literature.…”