Mucormycosis of the mandible after dental extractions in a patient with acute myelogenous leukemia

Salisbury, Paul Lee; Caloss, Ron; Cruz, Julia M.; Powell, Bayard L.; Cole, R D; Kohut, Robert I.

doi:10.1016/s1079-2104(97)90240-7

Cited by 62 publications

(48 citation statements)

References 7 publications

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“…Furthermore, it has been suggested that vascular ruptures and bleeding due to dental extractions may create a portal of entry for fungi into the maxillofacial regions. 5,20 Intraorally, the hard palate is usually affected because of its proximity to the infection of the nasal fossa and paranasal sinuses. In addition, isolated intraoral involvement is extremely rare.…”

Section: Discussionmentioning

confidence: 99%

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Mucormycosis of the Hard Palate Masquerading As Carcinoma

Manjunatha

Das

Sutariya

et al. 2012

Clinics and Practice

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A growing number of medically compromised patients are encountered by dentists in their practices. Opportunistic fungal infections such as mucormycosis usually occur in immunocompromised patients but can infect healthy individuals as well. Mucormycosis is an acute opportunistic, uncommon, frequently fatal fungal infection, caused by a saprophytic fungus that belongs to the class of phycomycetes. Among the clinical differential diagnosis we can consider squamous cell carcinoma. Such cases present as chronic ulcers with raised margins causing exposure of underlying bone. There is a close histopathological resemblance between mucormycosis and aspergillosis. Microscopically, aspergillosis has septate branching hyphae, which can be distinguished from mucormycotic hyphae by a smaller width and prominent acute angulations of branching hyphae. A definitive diagnosis of mucormycosis can be made by tissue biopsy that identifies the characteristic hyphae, by positive culture or both. The culture of diseased tissue may be negative and histopathologic examination is essential for early diagnosis. Mucormycosis was long regarded as a fatal infection with poor prognosis. However with early medical and surgical management survival rates are now thought to exceed 80%. In the present case, the fungus was identified by hematoxylin and eosin stain and confirmed by Grocott's silver methenamine special staining technique. Removal of the necrotic bone, which acted as a nidus of infection, was done. Post-operatively patient was advised an obturator to prevent oronasal regurgitation. Since mucormycosis occurs infrequently, it may pose a diagnostic and therapeutic dilemma for those who are not familiar with its clinical presentation.

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Section: Discussionmentioning

confidence: 99%

“…5,6 The disease has a worldwide distribution without age or race preference. 7 Rhinocerebral form of mucormycosis frequently presents with oral manifestations and may lead to considerable dilemma in clinicians unfamiliar with this entity, which in turn may worsen the prognosis for the patient.…”

Section: Introductionmentioning

confidence: 99%

Mucormycosis of the Hard Palate Masquerading As Carcinoma

Manjunatha

Das

Sutariya

et al. 2012

Clinics and Practice

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“…and several bacterial co-pathogens were isolated from debrided tissue. Salisbury and coworkers reported a 60-year-old with acute myelogenous leukemia who similarly developed progressive gingival necrosis following the extraction of four second molars (Salisbury et al, 1997). Stains of debrided soft tissue demonstrated hyphal elements and an unspecified member of the Mucorales family was isolated from tissue.…”

Section: Discussionmentioning

confidence: 99%

Zygomycosis originating from an odontogenic infection in a pediatric oncology patient

Adderson

Rowland

McGregor

et al. 2010

Diagnostic Microbiology and Infectious Disease

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“…900 ml blood was evacuated and advice for gradual decompression, unclamping for 5-6 seconds and occurs in the maxillofacial region, there are only few reported cases of RM in the mandible. 6,17 Radiographically, maxillary mucormycosis typically shows opacification of the paranasal sinuses without fluid level, thickening of the sinus mucosa and bone distraction of the sinus walls [ Figure: 7& 8]. As some of these radiographic features may resemble sinusitis, McDonogh et al warned that any diabetic patient in a ketoacidotic state presenting with clinical and radiographic features of rhinosinusitis should be suspected as having mucormycosis until proven otherwise 21 .…”

Section: Examination Of Eyesmentioning

confidence: 99%

“…Once fungal hyphae enter into the blood stream they can disseminate to other organs such as cerebrum or lungs which can be fatal for the patient. Mucor hyphae form thrombi within the blood vessels which reduce vascularity to the tissues and cause necrosis 17 . With orbital involvement, function of the cranial nerves II, III, IV and VI may be lost or impaired, with resultant proptosis, ptosis, papillary dilation, visual loss as well as periorbital cellulitis.…”

Section: Examination Of Eyesmentioning

confidence: 99%

Rhino Cerebral Mucormycosis with Post Surgical Complications in Diabetes: A Case Report

Mahmood

Quraishi

Shahid³

et al. 2017

Anwer Khan Mod Med Coll J

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Rhinocerebral mucormycosis is a rare life-threatening infection caused by fungi from the order Mucorales. The disease occurs mostly in association with diabetic ketoacidosis. Because of its rapid progression and high mortality, early recognition and aggressive treatment offer the only chance to increase the survival rate. A case of rhinocerebral mucormycosis in a diabetic male patient presenting as post surgical complication is reported. The clincal manifestations, diagnosis, and treatment of rhinocerebral mucormycosis are discussed.Anwer Khan Modern Medical College Journal Vol. 7, No. 2: Jul 2016, P 56-62

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Mucormycosis of the mandible after dental extractions in a patient with acute myelogenous leukemia

Cited by 62 publications

References 7 publications

Mucormycosis of the Hard Palate Masquerading As Carcinoma

Mucormycosis of the Hard Palate Masquerading As Carcinoma

Zygomycosis originating from an odontogenic infection in a pediatric oncology patient

Rhino Cerebral Mucormycosis with Post Surgical Complications in Diabetes: A Case Report

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