Mucormycosis: Oral and prosthodontic implications. A report of 14 patients

Kurrasch, Madeline; Beumer, John; Kagawa, Tsuneo

doi:10.1016/s0022-3913(82)80095-4

Cited by 24 publications

(22 citation statements)

References 14 publications

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“…The infection is often associated with acidosis due to diabetes, diarrhea, or uremia. Diabetic acidosis was considered to be the predisposing condition in 50–70% of the reported patients with mucormycosis prior to the HIV pandemic (103,104). More recently it is commonly seen associated with HIV infection and AIDS (101,105).…”

Section: Oral Manifestations Of Uncommon Systemic Mycosesmentioning

confidence: 99%

Candidiasis and other fungal diseases of the mouth

2002

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The advent of the human immunodeficiency virus (HIV) and the increasing prevalence of immunocompromised individuals due to surgical and medical advances have resulted in a resurgence of opportunistic infections including oral candidiasis and other rare mycoses which were once considered exotic. It is now recognized that oral candidiasis may present in many clinical guises that may confound the unwary clinician. Other mycotic diseases such aspergillosis, cryptococcosis, histoplasmosis, and mucormycosis may manifest intraorally both as primary lesions and as secondary manifestation of systemic disease. The primary oral pathology of most of the latter mycoses is ulcerations that respond well to systemic therapy with the polyene, amphotericin B. In general, the management of oral fungal infections has been revolutionized by the triazole group of drugs, fluconazole and itraconazole, although recent reports indicate an alarming increase of resistant organisms in particular to fluconazole. The first part of this review attempts to provide an overview of clinical variants of oral candidiasis and current therapeutic techniques, while the latter part outlines the rare oral mycoses and their management.

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Section: Oral Manifestations Of Uncommon Systemic Mycosesmentioning

confidence: 99%

Candidiasis and other fungal diseases of the mouth

2002

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“…These have usually suffered from the rhinocerebral form (Muresan, 1960;Baum, 1967;Blodi et al, 1969;Kurrasch et al, 1982), though the pulmonary (Record & Ginder, 1976) and gastrointestinal (Horowitz et al, 1974) varieties have also been seen in previously healthy people. The significance of such cases is not easily understood, for few appear to have been followed-up for a significant period, and little attention has been paid to the more subtle defects of leucocyte function that may arise from specific genetic anomalies.…”

Section: Other Underlying Conditionsmentioning

confidence: 99%

“…Where appropriate, lung or gut resection may be valuable (Eden & Santos, 1979;Gribetz et al, 1980;Wright et al, 1980). Adequate surgery to the face may leave a substantial defect, and since such patients may have, on recovery, a good life expectancy, there is a major challenge to the skills of prosthetists (Kurrasch et al, 1982). Cures have followed medical treatment alone (Hauch, 1977;Hamill et al, 1983), but adequate debridement as well provides a much better prognosis (Anaissie & Shikhani, 1985).…”

Section: Treatment and Prognosismentioning

confidence: 99%

Systemic zygomycosis

Benbow

Stoddart

1986

Postgraduate Medical Journal

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“…More frequently, mucormycosis begins as a clinically subtle sinusitis or periorbital panniculitis, but, occasionally, patients with mucormycosis may be referred to dentists for dental pain or subperiostal swelling of the jaws [15]. Delayed diagnosis or inappropriate treatment may result in mucosal ulceration and bone destruction, leading to intra-and extra-oral mid-facial defects that require surgical intervention [15]. Nevertheless, mucormycosis frequently is lethal for the patients, due to extensive tissue destruction and brain involvement.…”

Section: Introductionmentioning

confidence: 99%

Combined mucormycosis and aspergillosis of the oro-sinonasal region in a patient affected by Castleman disease

et al. 2004

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One case of aspergillosis and mucormycosis occurring in a patient with stage-IV Castleman disease was investigated. The patient, who had undergone polychemotherapy and was in otherwise good general condition, without lymphadenopathies or imbalance of the immune system, presented with a palatal ulceration that progressively involved the palatal mucosa and bone, the paranasal sinuses and the orbit. Repeated cultural examinations were always negative. He had undergone multiple cytological smears of the inflammatory infiltration and biopsies of both the oral and nasal mucosa, which resulted in extensive necrotic debris and suppurative inflammation, and, on the very last biopsy, fungal hyphae, spores and conidia were also detected. These were large, branching, mostly non-septate hyphae, associated with conidiophores and conidia, the latter appearing dark brown to black in the histological preparations. Following the diagnosis of combined mucormycosis and aspergillosis, the patient underwent prolonged topic and systemic antibiotic treatment that resulted curative. Mucormycosis usually is a fatal complication of head and neck or systemic disorders, leading to severe immune suppression. Nevertheless, early diagnosis may be achieved using a combination of special stains and may lead to effective antibiotic treatment and cure of the patient, even if associated with other opportunistic infections, such as aspergillosis.

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Mucormycosis: Oral and prosthodontic implications. A report of 14 patients

Cited by 24 publications

References 14 publications

Candidiasis and other fungal diseases of the mouth

Candidiasis and other fungal diseases of the mouth

Systemic zygomycosis

Combined mucormycosis and aspergillosis of the oro-sinonasal region in a patient affected by Castleman disease

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