Mucosa-associated lymphoid tissue lymphoma of the duodenum together with multiple intra-abdominal thromboses and hepatitis C virus infection: a case report

Abstract

Mucosa associated lymphoid tissue MALT lymphoma is a low grade malignancy that arises most commonly from the gastric mucosa. Small intestinal involvement is very rare. The causative relationship between Helicobacter pylori and the gastric MALT lymphoma is a well known issue, but recently there are several data suggesting the role of hepatitis C virus (HCV) infection in the pathogenesis of lymphoma including MALT lymphoma. Herein we present a rare case of duodenal MALT lymphoma with multiple intra-abdominal thromboses together with HCV infection that was confirmed by real-time polymerase chain reaction detecting HCV-RNA within the peripheral blood mononuclear cells.

Acute pancreatitis as the first manifestation of duodenal MALT lymphoma

“…Another interesting case of duodenal MALT lymphoma diagnosed together with multiple intra-abdominal thromboses and hepatitis C virus infection was published in 2009 by Ozkok et al 8 .…”

“…However, its contribution to the pathogenesis of lymphomas is not perfectly clear. It has been discussed as a potential infectious co-factor in the multiple-stage pathogenesis of MALT lymphomas 8 .…”

Acute pancreatitis as the first manifestation of duodenal MALT lymphoma

“…Histological investigation confirmed this tumor to be marginal B cell lymphoma 5 . Another interesting case of duodenal MALT lymphoma diagnosed together with multiple intra-abdominal thromboses and hepatitis C virus infection was published in 2009 by Ozkok et al 8 . Our case report is rare not only for the duodenal type of MALT lymphoma, but also for the unique manifestation of this neoplasm.…”

“…However, its contribution to the pathogenesis of lymphomas is not perfectly clear. It has been discussed as a potential infectious co-factor in the multiple-stage pathogenesis of MALT lymphomas 8 5,19 . Contrary to gastric MALT lymphoma, the role of Helicobacter pylori remains unclear.…”

Mantle Cell Lymphoma Presenting as a Gastric Mass & Multiple Lymphomatous Polyposis of the Duodenum: A Case Report and Review of the Literature

“…It has been shown that its eradication can be either effective [58][59][60] or ineffective [54,[61][62][63]. In MALT lymphoma, the pathogenesis is explained by Helicobacter pylori chronically stimulating the immune system of the GI tract to maintain an extended and prolonged proliferative state, thereby increasing the likelihood of lymphoid transformation [64]. Whether or not H. pylori have any role in MCL pathogenesis is yet to be determined.…”