Mucosa-associated lymphoid tissue (MALT) variant of primary rectal lymphoma: a review of the English literature

Kelley, Scott R.

doi:10.1007/s00384-016-2734-z

Cited by 17 publications

(14 citation statements)

References 57 publications

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“…Approximately 20% of patients with colorectal MALT lymphoma are H. pylori positive, and other chronic inflammation has not been documented except for a case of rectal MALT lymphoma that was possibly associated with primary biliary cirrhosis and secondary Sjögren syndrome [ 37 , 38 , 39 ]. MALT lymphoma of the large intestine affects individuals in their fifth through seventh decades, with a female predominance [ 38 , 40 , 41 ]. The ileocecum and the rectum are commonly affected [ 40 , 42 ].…”

Section: Clinicopathological Features Of Gi Lymphomasmentioning

confidence: 99%

“…Patients with colorectal MALT lymphoma sometimes present with abdominal discomfort, diarrhea, constipation, or a positive fecal occult blood test [ 40 , 43 ]. Approximately 90% of colorectal MALT lymphomas are localized clinical stage Lugano I-II, and bone marrow involvement is rarely seen (4–9%) [ 37 , 40 , 41 ].…”

Section: Clinicopathological Features Of Gi Lymphomasmentioning

confidence: 99%

“…In the rectum, a polypoid lesion has been reported to be 10-fold more common than an ulcerative lesion [ 37 ]. The tumors also vary in size, with the majority measuring between 15 and 30 mm [ 39 , 41 , 43 , 72 ]. A magnified endoscopy of the tumor surface shows a type I pit pattern with dilated tree-like microvessels on NBI [ 73 ].…”

Section: Endoscopic Findingsmentioning

confidence: 99%

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Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in the Gastrointestinal Tract in the Modern Era

Ishikawa

Nakamura

Satou

et al. 2022

Cancers

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Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) typically arises from sites such as the stomach, where there is no organized lymphoid tissue. Close associations between Helicobacter pylori and gastric MALT lymphoma or Campylobacter jejuni and immunoproliferative small intestinal disease (IPSID) have been established. A subset of tumors is associated with chromosomal rearrangement and/or genetic alterations. This disease often presents as localized disease, requiring diverse treatment approaches, from antibiotic therapy to radiotherapy and immunochemotherapy. Eradication therapy for H. pylori effectively cures gastric MALT lymphoma in most patients. However, treatment strategies for H. pylori-negative gastric MALT lymphoma are still challenging. In addition, the effectiveness of antibiotic therapy has been controversial in intestinal MALT lymphoma, except for IPSID. Endoscopic treatment has been noted to usually achieve complete remission in endoscopically resectable colorectal MALT lymphoma with localized disease. MALT lymphoma has been excluded from post-transplant lymphoproliferative disorders with the exception of Epstein–Barr virus (EBV)-positive marginal zone lymphoma (MZL). We also describe the expanding spectrum of EBV-negative MZL and a close association of the disease with the gastrointestinal tract.

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Section: Clinicopathological Features Of Gi Lymphomasmentioning

confidence: 99%

Section: Clinicopathological Features Of Gi Lymphomasmentioning

confidence: 99%

Section: Endoscopic Findingsmentioning

confidence: 99%

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Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in the Gastrointestinal Tract in the Modern Era

Ishikawa

Nakamura

Satou

et al. 2022

Cancers

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“…Matsuo et al [ 13 ] reported a case of H. pylori -positive colon MALT lymphoma but did not report H. pylori eradication treatment. Kelley[ 14 ] retrospectively analyzed 51 primary rectal lymphoma patients, only 12 of whom were H. pylori -positive, and did not confirm a relationship between this bacterium and the disease because there was no direct pathological evidence on rectal biopsy. Kikuchi et al [ 15 ] summarized the literature on antibiotic treatment in patients with H. pylori -negative primary colorectal lymphoma and found that it may be associated with other luminal microorganisms.…”

Section: Discussionmentioning

confidence: 99%

Laterally spreading tumor-like primary rectal mucosa-associated lymphoid tissue lymphoma: A case report

Wei¹,

Min²,

Ren³

et al. 2021

WJCC

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BACKGROUND Colorectal mucosa-associated lymphoid tissue (MALT) lymphoma is a rare disease, and only a few cases have been reported to date. It has no specific clinical presentations and shows various endoscopic appearances. There is no uniform consensus on its treatment. With the advancement of endoscopic technology, endoscopic treatment has achieved better results in individual case reports of early-stage patients. CASE SUMMARY We report a case of rectal MALT in a 57-year-old Chinese man with no symptoms who received endoscopy as part of a routine physical examination, which incidentally found a 25 mm × 20 mm, laterally spreading tumor (LST)-like elevated lesion in the rectum. Therefore, he was referred to our hospital for further endoscopic treatment. Complete and curable removal of the tumor was performed by endoscopic submucosal dissection. We observed enlarged and dilated branch-like vessels similar to those of gastric MALT lymphoma on magnifying endoscopy with narrow-band imaging. And immunopathological staining showed hyperplastic capillaries in the mucosa. Histopathological findings revealed diffusely hyperplastic lymphoid tissue in the lamina propria, with a visible lymphoid follicle structure surrounded by a large number of diffusely infiltrated lymphoid cells that had a relatively simple morphology and clear cytoplasm. In addition, immunohistochemical analysis suggested strongly positive expression for CD20 and Bcl-2. Gene rearrangement results showed positivity for IGH-A, IGH-C, IGK-B, and IGL. Taking all the above findings together, we arrived at a diagnosis of extranodal marginal zone B-cell lymphoma of MALT lymphoma. Positron emission tomography-computed tomography examination showed no other lesions involved. The patient will be followed by periodic endoscopic observation. CONCLUSION In conclusion, we report a case of rectal MALT with an LST-like appearance treated by endoscopic submucosal dissection. Further studies will be needed to explore the clinical behavior, endoscopic appearance, and treatment of rectal MALT.

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“…Although most often found in the stomach, 2.5% of MALT lymphomas are found in the colon [2]. In addition, since colonic MALT lymphomas are often detected in the invasion depth of mucosal and submucosal layers as relatively small tumors, they are extremely rarely found as a deeply invasive mass-forming tumor [3][4][5]. The association between gastric MALT lymphoma and chronic Helicobacter pylori (H. pylori) infection is evident, so the treatment of gastric MALT lymphomas is well established.…”

Section: Introductionmentioning

confidence: 99%

Mass-forming mucosa-associated lymphoid tissue lymphoma of the cecum treated by laparoscopy-assisted bowel resection

et al. 2019

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Colonic mucosa-associated lymphoid tissue (MALT) lymphoma is very rare, especially those which form a mass. Although the characteristics and treatment methods of gastric MALT lymphomas are well established, those of colonic MALT lymphomas have been insufficiently described. Here, we report a case of mass-forming cecal MALT lymphoma that was successfully treated by laparoscopy-assisted bowel resection. A 60-year-old woman with right lower abdominal pain and a palpable tumor was referred to our hospital. Colonoscopy showed a smooth elevated submucosal tumor-like lesion in the cecum. Histological and immunochemical findings were consistent with MALT lymphoma. Serum tumor marker levels were within normal range. Enhanced abdominal computed tomography showed a large tumor 55 mm in diameter in the cecum and edema of a few paracolic lymph nodes. The tumor was diagnosed as cecal MALT lymphoma classified as stage II1 by Lugano classification, and laparoscopy-assisted ileocecal resection was performed. The postoperative course was uneventful and the patient underwent eradication therapy for Helicobacter pylori. A year after the operation she has had no recurrence. In patients with mass-forming colonic MALT lymphoma without dissemination, surgical resection may be a feasible treatment.

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Mucosa-associated lymphoid tissue (MALT) variant of primary rectal lymphoma: a review of the English literature

Abstract: Complete regression of primary rectal MALT lymphoma was achieved using various therapeutic strategies, although the numbers of different treatment modalities are too small to draw definitive conclusions.

Cited by 17 publications

References 57 publications

Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in the Gastrointestinal Tract in the Modern Era

Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in the Gastrointestinal Tract in the Modern Era

Laterally spreading tumor-like primary rectal mucosa-associated lymphoid tissue lymphoma: A case report

Mass-forming mucosa-associated lymphoid tissue lymphoma of the cecum treated by laparoscopy-assisted bowel resection

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