Mucosal Adherence of Human Enteropathogenic Escherichia Coli

Escherichia coliin gastroenteritis of children in London and Jamaica

“…None the less, the negative toxin tests on jejunal isolations of E. coli must throw further doubt on the idea that enterotoxin production is the only pathogenic factor in infant gastroenteritis. Strains which produce enterotoxin may also require other properties such as mucosal adherence (McNeish et al 1975) and colonizing capacity ) before they are able to cause diarrhoea. Furthermore, some E. coli cause diarrhoea by mechanisms which do not involve enterotoxin.…”

The Fimbrial and Non-Fimbrial Haemagglutinins of Escherichia Coli

“…Interest in the haemagglutinating properties of E. coli has been re-awakened by discoveries associating them with the presence of particular K antigens, adhesiveness for intestinal epithelium, ability to colonise the upper intestine, and enteropathogenicity in man (Duguid, 1964;Evans et al, 1975;McNeish .et al., 1975;Evans, Evans and Tjoa, 1977;0rskov and 0rskov, 1977), pigs (Stirm et al, 1967;Jones andRutter, 1972,1974;Hohmann and Wilson, 1975;Isaacson, Nagy and Moon, 1977;Parry and Porter, 1978) and in calves {Burrows, Sellwood and Gibbons, 1976). Because different strains of E. coli may possess one or more kinds of haemagglutinin that require different cultural conditions for their development and different techniques and species of erythrocytes for their demonstration, and because most published studies have been made with only a few strains and a restricted range of tests, we thought it valuable to describe the haemagglutinating properties of a wide range of strains from different serotypes and sources.…”

Gastroenteritis in London and Jamaica: a clinical and bacteriological study

“…It is less certain however that malnutrition alone is accompanied by a small bowel flora abnormal for their background environment. The possibility that 'normal' bacteria in a malnourished bowel might however have special effects is still not excluded, and the relative significance of organisms attached to bowel mucosa is now under active study both in tropical sprue (Tomkins, Drasar & James, 1975) and in gastro-enteritis (McNeish et al 1975;Leading Article, 1977 (Leading Article, 1975). If production of enterotoxin is an important mechanism in the pathogenesis of acute diarrhoea, abnormal jejunal colonization should be found commonly in diarrhoeal disease, although such a finding must be interpreted cautiously in view of the non-specific influences of diarrhoea previously discussed (Gorbach et at.…”