Mucosal Adjuvants

Elson, Charles O.; Dertzbaugh, Mark T.

doi:10.1016/b978-0-12-524730-6.50038-5

Cited by 45 publications

(32 citation statements)

References 91 publications

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“…Cholera toxin (CT), one of the most potent mucosal immunogens identified to date, has been shown to enhance the immunogenicity of relatively poor mucosal immunogens, such as the influenza virus , when co-delivered orally (Elson & Dertzbaugh, 1994). A combination of CT and a protein based T-dependent soluble antigen, such as ovalbumin (OVA), is therefore a good model to study mucosal immuno-responses (Elson & Dertzbaugh, 1994).…”

Section: Introductionmentioning

confidence: 99%

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Enhancement of Mucosal Antibody Responses by Dietary Whey Protein Concentrate

Low¹,

Rutherfurd²,

Cross³

et al. 2001

Food and Agricultural Immunology

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The effect of dietary bovine whey protein concentrate (WPC) on gut mucosal antibody responses to orally-administered antigens was investigated in BALB/c mice. Test mice were fed a diet containing 20% (w /w ) total protein of a novel WPC (ALACEN 472) for 12 weeks.Test and control (chow-fed) mice were immunized orally with cholera toxin (CT) and ovalbumin (OVA) at different times throughout the dietary regime, and gut mucosal antibody responses were assessed at the end of the experiment. Both groups of mice produced mucosal antibodies against CT and OVA, although responses were significantly higher among WPCfed mice, regardless of the time-point at which immunizations were administered throughout the study. WPC had no significant effect on blood lymphocyte phenotype expression or splenic T or B cell mitogenesis, suggesting that the immunomodulatory action was not due to systemic lymphocyte activation. This study confirms previous reports that dietary WPC can potentiate humoral immunity in mice, and provides the first evidence that WPC can enhance mucosal antibody responses to orally-administered antigens.

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Section: Introductionmentioning

confidence: 99%

“…A combination of CT and a protein based T-dependent soluble antigen, such as ovalbumin (OVA), is therefore a good model to study mucosal immuno-responses (Elson & Dertzbaugh, 1994). The objective of this study was to first determine whether dietary WPC could modulate mucosal antibody responses to CT and OVA co-administered orally to mice.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Mucosal Antibody Responses by Dietary Whey Protein Concentrate

Low¹,

Rutherfurd²,

Cross³

et al. 2001

Food and Agricultural Immunology

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“…35 In Cirebon during the British interregnum, 'the most beautiful and productive coffee plantations' were cut down to establish rice fields. 36 But switching from coffee to foodstuffs was quite rational. Coffee marketing was thoroughly disrupted by the British blockade of Java, and poor coffee prices prevailed after the Napoleonic wars, falling to as low as a third of former levels by 1826.…”

Section: The Evolution Of Forced Coffee Cultivation In Nineteenth-cenmentioning

confidence: 99%

“…Much coffee was what the Dutch disparagingly and rather misleadingly referred to as kopi pagar (hedgerow coffee), notably in Kedu and Banyumas. 87 Hedges had a low productivity per tree, but output per hectare was high, and they served a useful double function. Moreover, much of the coffee classified as kopi pagar was in reality grown in small plots close to villages.…”

Section: The Evolution Of Forced Coffee Cultivation In Nineteenth-cenmentioning

confidence: 99%

“…11^ A decree of 1866 restricting coffee cultivation to within four paal of the villages assigned to these tasks was abruptly withdrawn the following year, when it threatened ruin to government income from Pasuruan and Priangan. 117 Replanting in old coffee lands became the centre-piece of the reforms, but it was a signal failure. Half-hearted attempts were made in Cirebon to replant old coffee groves close to villages, but this was alleged to have contributed to devastating attacks of leaf blight.…”

Section: The Evolution Of Forced Coffee Cultivation In Nineteenth-cenmentioning

confidence: 99%

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The impact of forced coffee cultivation on Java, 1805–1917

Clarence‐Smith¹

1994

Indonesia Circle. School of Oriental & African Studies. New

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Induction of Th1 and Th2 CD4⁺ T cell responses by oral or parenteral immunization with ISCOMS

1995

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We examined the ability of oral or parenteral immunization with immune stimulating complexes containing ovalbumin (ISCOMS-OVA) to prime T cell proliferative and cytokine responses. A single subcutaneous immunization with ISCOMS-OVA primed potent antigen-specific proliferative responses in the draining popliteal lymph node, which were entirely dependent on the presence of CD4+ T cells. CD8+ T cells did not proliferate in vitro even in the presence of the appropriate peptide epitope and exogenous interleukin (IL)-2. Primed popliteal lymph node cells produced IL-2, IL-5 and interferon (IFN)-gamma, but not IL-4 when restimulated with OVA in vitro. Serum antigen-specific IgG1 and IgG2a antibody responses were also primed by subcutaneous immunization with ISCOMS-OVA, confirming the stimulation of both Th1 and Th2 cells in vivo. Spleen cells from subcutaneously primed mice produced a similar pattern of cytokines, indicating that disseminated priming had occurred. Oral immunization with ISCOMS-OVA also primed local antigen-specific proliferative responses in the mesenteric lymph node and primed an identical pattern of systemic cytokine responses in the spleen. The ability of ISCOMS to prime both Th1 and Th2 CD4+ T cell responses may be central to their potent adjuvant activities and confirm the potential of ISCOMS as future oral vaccine vectors.

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Mucosal Adjuvants

Cited by 45 publications

References 91 publications

Enhancement of Mucosal Antibody Responses by Dietary Whey Protein Concentrate

Enhancement of Mucosal Antibody Responses by Dietary Whey Protein Concentrate

The impact of forced coffee cultivation on Java, 1805–1917

Induction of Th1 and Th2 CD4⁺ T cell responses by oral or parenteral immunization with ISCOMS

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Mucosal Adjuvants

Cited by 45 publications

References 91 publications

Enhancement of Mucosal Antibody Responses by Dietary Whey Protein Concentrate

Enhancement of Mucosal Antibody Responses by Dietary Whey Protein Concentrate

The impact of forced coffee cultivation on Java, 1805–1917

Induction of Th1 and Th2 CD4+ T cell responses by oral or parenteral immunization with ISCOMS

Contact Info

Product

Resources

About

Induction of Th1 and Th2 CD4⁺ T cell responses by oral or parenteral immunization with ISCOMS