Mucosal Bioengineering: Gut in a Dish

Ivanov, Ivaylo I.

doi:10.1016/j.it.2017.06.007

Cited by 2 publications

(1 citation statement)

References 9 publications

(9 reference statements)

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“…The authors were able to maintain both aerobic and anaerobic bacterial growth for the duration of the study (24 h) and identified immune and nonimmune transcriptional and functional responses to bacterial stimulation; thus, proteomics characterization of the system could be readily applied. While in its present form, this system has not yet been developed for human organs; advances in humanized mouse models may permit its application in human cell/tissues responses …”

Section: Model Systems To Study Bacteria Host–bacteria Interactions A...mentioning

confidence: 99%

Proteomic and Metaproteomic Approaches to Understand Host–Microbe Interactions

Starr

Deeke

et al. 2017

Anal. Chem.

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Section: Model Systems To Study Bacteria Host–bacteria Interactions A...mentioning

confidence: 99%

Proteomic and Metaproteomic Approaches to Understand Host–Microbe Interactions

Starr

Deeke

et al. 2017

Anal. Chem.

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Development and Organization of the Secondary and Tertiary Lymphoid Organs: Influence of Microbial and Food Antigens

Magrone

Jirillo

2019

EMIDDT

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Background:Secondary lymphoid organs (SLO) are distributed in many districts of the body and, especially, lymph nodes, spleen and gut-associated lymphoid tissue are the main cellular sites. On the other hand, tertiary lymphoid organs (TLO) are formed in response to inflammatory, infectious, autoimmune and neoplastic events. Developmental Studies: In the present review, emphasis will be placed on the developmental differences of SLO and TLO between small intestine and colon and on the role played by various chemokines and cell receptors. Undoubtedly, microbiota is indispensable for the formation of SLO and its absence leads to their poor formation, thus indicating its strict interaction with immune and non immune host cells. Furthermore, food antigens (for example, tryptophan derivatives, flavonoids and byphenils) bind the aryl hydrocarbon receptor on innate lymphoid cells (ILCs), thus promoting the development of postnatal lymphoid tissues. Also retinoic acid, a metabolite of vitamin A, contributes to SLO development during embryogenesis. Vitamin A deficiency seems to account for reduction of ILCs and scarce formation of solitary lymphoid tissue. Translational Studies: The role of lymphoid organs with special reference to intestinal TLO in the course of experimental and human disease will also be discussed. Future Perspectives: Finally, a new methodology, the so-called “gut-in-a dish”, which has facilitated the in vitro interaction study between microbe and intestinal immune cells, will be described.

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Mucosal Bioengineering: Gut in a Dish

Abstract: Studying the interactions between commensal microbes and host intestinal tissue networks is challenging due to the complexity and inaccessibility of the system. A recent study reports a novel organ culture system that will enhance our ability to dissect these interactions.

Cited by 2 publications

References 9 publications

Proteomic and Metaproteomic Approaches to Understand Host–Microbe Interactions

Proteomic and Metaproteomic Approaches to Understand Host–Microbe Interactions

Development and Organization of the Secondary and Tertiary Lymphoid Organs: Influence of Microbial and Food Antigens

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