Mucosal biofilms of Candida albicans

Ganguly, Shantanu; Mitchell, Aaron P.

doi:10.1016/j.mib.2011.06.001

Cited by 175 publications

(135 citation statements)

References 58 publications

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“…Biofilm formation by fungal pathogens on implanted medical devices is a serious medical problem (Ganguly and Mitchell, 2011). Cell adhesion and biofilm formation by C. albicans cells on host surfaces are also the first step in establishing infection.…”

Section: Resultsmentioning

confidence: 99%

(1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition

Zhao

Huang

Sun

et al. 2018

Microbial Biotechnology

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SummaryClinical treatment of Candida albicans infections has become more difficult due to the limited development of antifungal agents and the rapid emergence of drug resistance. In this study, we demonstrate the synthesis of a series of piperazine derivatives and the evaluation of their inhibitory activity against C. albicans virulence. Thirty‐four (1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives, including 25 new compounds, were synthesized and assessed for their efficacy against the physiology and pathogenesis of C. albicans. Several compounds strongly inhibited the morphological transition and virulence of C. albicans cells, although they did not influence the growth rate of the fungal pathogen. A leading novel compound, (1‐(4‐ethoxyphenyl)‐4‐(1‐biphenylol‐2‐hydroxypropyl)‐piperazine), significantly attenuated C. albicans virulence by interfering with the process of hyphal development, but it showed no cytotoxicity against human cells at a micromolar level. These findings suggest that (1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives could potentially be developed as novel therapeutic agents for the clinical treatment of C. albicans infections by interfering with morphological transition and virulence.

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Section: Resultsmentioning

confidence: 99%

(1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition

Zhao

Huang

Sun

et al. 2018

Microbial Biotechnology

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“…Fungal biofilm formation on implanted medical devices is a serious medical problem, because these biofilms can lead to life-threatening systemic infections (18). An established in vitro assay to study device colonization measures biofilm formation on surgical silicone elastomers (19).…”

Section: Resultsmentioning

confidence: 99%

Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis

Fazly¹,

Jain

Dehner³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

101

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Infection by pathogenic fungi, such as Candida albicans, begins with adhesion to host cells or implanted medical devices followed by biofilm formation. By high-throughput phenotypic screening of small molecules, we identified compounds that inhibit adhesion of C. albicans to polystyrene. Our lead candidate compound also inhibits binding of C. albicans to cultured human epithelial cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter, biofilm formation on silicone elastomers, and pathogenesis in a nematode infection model as well as alters fungal morphology in a mouse mucosal infection assay. We term this compound filastatin based on its strong inhibition of filamentation, and we use chemical genetic experiments to show that it acts downstream of multiple signaling pathways. These studies show that high-throughput functional assays targeting fungal adhesion can provide chemical probes for study of multiple aspects of fungal pathogenesis.hyphal morphogenesis | small molecule screening | fungal pathogens

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“…[1][2][3] Biofilms have been suggested to be an important factor in the pathogenesis of several Candida species. Due to the biofilms thickness and density, and likely due to the metabolic state of the yeast, antifungal drugs are not very effective in eradicating yeast contained therein.…”

Section: Introdutionmentioning

confidence: 99%

Biofilm Antifungal Susceptibility of Candida Urine Isolated from Ambulatory Patients

Becker¹,

Bulle²,

Rodrigues³

et al. 2016

Rev Epidemiol Control Infect

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Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. Justificativa e Objetivos: A associação entre a formação de biofilme e resistência antifúngica foi sugerida por ser um fator importante na patogênese de diversas espécies de Candida. Além disso, estudos têm incluído candidíase invasiva de pacientes hospitalizados; no entanto, existem poucos estudos que avaliaram a distribuição das espécies, suscetibilidade aos antifúngicos e formação de biofilme de espécies de Candida isoladas de pacientes ambulatoriais. Assim, o objetivo deste estudo foi avaliar se a produção de biofilme contribui para a resistência antifúngica em Candida isoladas de amostras de urina obtidas de pacientes de ambulatório. (1/9) de C. tropicalis foram resistentes cetoconazol e foram anidulafungina (ANI) não-suscetíveis. Conclusão: MétodosNossos resultados mostraram a alta capacidade de formação de biofilme entre espécies de Candida isoladas de pacientes ambulatoriais.Background and Objectives: the association between the biofilm formations an antifungal resistance has

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Mucosal biofilms of Candida albicans

Cited by 175 publications

References 58 publications

(1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition

(1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition

Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis

Biofilm Antifungal Susceptibility of Candida Urine Isolated from Ambulatory Patients

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