Mucosal CD30-positive T-cell lymphoproliferations of the head and neck show a clinicopathologic spectrum similar to cutaneous CD30-positive T-cell lymphoproliferative disorders

Sciallis, Andrew P.; Law, Mark E.; Inwards, David J.; McClure, Rebecca F.; Macon, William R.; Kurtin, Paul J.; Doğan, Ahmet; Feldman, Andrew L.

doi:10.1038/modpathol.2012.38

Cited by 54 publications

(42 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CD30 + LPD may involve or be restricted to mucosal sites, particularly the oral cavity, orbit/conjunctiva, or nasal cavity/sinuses. 90,91 Similar cases have previously been reported as traumatic ulcerative granuloma with stromal eosinophilia. 92 Sciallis et al 91 referred to this condition as mucosal CD30 + T-cell lymphoproliferations of the head and neck and demonstrated that some of the lesions show a clinicopathologic spectrum similar to cutaneous CD30 + T-cell LPDs.…”

Section: Primary Cutaneous Cd30 + Lymphoproliferative Disorderssupporting

confidence: 65%

Cutaneous Lymphomas

Kempf

Kazakov

Kerl

2014

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Primary cutaneous T-cell lymphomas (CTCL) represent the majority of cutaneous lymphomas (CLs) and are a spectrum of diseases with a wide variety of clinical, histological, and phenotypic features and diverse biologic behavior. This review focuses on the observations on new variants of CTCL and recent developments in deciphering the pathogenetic mechanisms, which have implication for the nosologic concepts and future classification of CLs. Variants of mycosis fungoides (MF) such as the unilesional and the papular form have been characterized in more detail. Studies analyzed the expression of CD30 and PD-1 in MF and other forms of CTCL. New variants in the group of cutaneous CD30⁺ lymphoproliferative disorders include the epidermotropic CD8⁺ variant of lymphomatoid papulosis (type D) and angiocentric lymphomatoid papulosis (type E), which histologically mimic aggressive lymphomas, and therefore may be diagnostically challenging. Cutaneous proliferations of T cell-expressing markers of follicular helper T cells (PD-1, CXCL-13, and bcl-6) display a prognostically heterogeneous group. There is an increasing spectrum of CTCL with the expression of CD8 by tumor cells, including CD8⁺ MF, CD8⁺ forms of cutaneous CD30⁺ lymphoproliferative disorders, and CD8⁺ small/medium-sized lymphoproliferations, which are not included as distinct entities in the World Health Organization-European Organization for Research and Treatment of Cancer for CLs and the World Health Organization classification. Unusual presentations and incomplete phenotypes of blastic neoplasm of plasmacytoid dendritic cells are discussed. Clinicopathologic correlation is mandatory for the diagnosis of primary CLs. Analysis of genetic and epigenetic alterations in CLs revealed new diagnostic markers and putative targets for therapy of aggressive forms of CLs.

show abstract

Section: Primary Cutaneous Cd30 + Lymphoproliferative Disorderssupporting

confidence: 65%

Cutaneous Lymphomas

Kempf

Kazakov

Kerl

2014

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…We and others have reported cases resembling ALK-negative ALCL in mucosal sites or the upper aerodigestive tract [38,39]. These cases have a spectrum of clinical presentations, including localized, primary mucosal cases; systemic cases secondarily involving mucosal surfaces; and cases occurring in patients with cutaneous T-cell lymphoproliferative disease/lymphoma.…”

Section: Chromosomal Rearrangements In Alk-negative Alclmentioning

confidence: 97%

Genetics of anaplastic large cell lymphoma

Zeng

Feldman

2015

Leukemia & Lymphoma

View full text Add to dashboard Cite

Anaplastic large cell lymphoma (ALCL) comprises a group of T-cell non-Hodgkin lymphomas unified by common morphologic and immunophenotypic characteristics, but with a spectrum of clinical presentations and behaviors. Early identification of anaplastic lymphoma kinase (ALK) gene rearrangements in some ALCLs led to recognition of ALK as an important diagnostic and prognostic biomarker, and a key driver of ALCL pathobiology. Rearrangements and other genetic abnormalities of ALK subsequently were identified in diverse other human malignancies. Recent clinical, pathologic, and genetic data have begun to shed light on ALK-negative ALCLs, revealing significant heterogeneity within this more ill-defined entity.

show abstract

“…61 Involvement of oral mucosa and lips were much more common in our series than it has been reported in other LyP variants, in which the occurrence of oral LyP lesions is exceedingly rare. In 1 patient in our series, the disease started with oral mucosa involvement.…”

Section: Discussionmentioning

confidence: 37%

Angioinvasive Lymphomatoid Papulosis

Kempf

Kazakov

Schärer

et al. 2013

American Journal of Surgical Pathology

185

View full text Add to dashboard Cite

Lymphomatoid papulosis (LyP) belongs to the spectrum of primary cutaneous CD30-positive lymphoproliferative disorders. Clinically, LyP is characterized by a variable number of self-healing papulo-nodular lesions, with the typical waxing and waning course. Histologically, 4 types (A, B, C, and D) have been delineated. Angioinvasive growth and large ulcers are rare findings in LyP and simulate aggressive lymphoma. We retrospectively analyzed the clinicopathologic and molecular features of angioinvasive LyP in a series of 16 patients. This new form of LyP is characterized by oligolesional papules that rapidly ulcerate and evolve into large necrotic eschar-like lesions with a diameter of 1 to 4 cm and an angiocentric and angiodestructive infiltrate of small-sized to medium-sized atypical lymphocytes expressing CD30 and frequently CD8. As in other forms of LyP, the lesions underwent spontaneous regression after a few weeks. Recurrences were common, but the prognosis was excellent with no extracutaneous spread or disease-related deaths. Complete remission occurred in 9 of 16 patients (56%). This LyP variant should be distinguished from aggressive forms of angiocentric and angiodestructive and cytotoxic T-cell lymphomas. We propose the term LyP type E for this clinically and histologically unusual variant.

show abstract

Mucosal CD30-positive T-cell lymphoproliferations of the head and neck show a clinicopathologic spectrum similar to cutaneous CD30-positive T-cell lymphoproliferative disorders

Cited by 54 publications

References 37 publications

Cutaneous Lymphomas

Cutaneous Lymphomas

Genetics of anaplastic large cell lymphoma

Angioinvasive Lymphomatoid Papulosis

Contact Info

Product

Resources

About