Mucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental application

Abstract

The current study aimed to investigate the effectiveness of a developed sodium alginate and polyvinylpyrrolidone K-25 (PVP K-25) polymeric wafer for the co-delivery of ketorolac and lidocaine to soft tissues for healing and pain control following gingivectomy. Nine ketorolac/lidocaine lyophilized wafers were formulated and assessed for their hydration capacity, mucoadhesion ability and in vitro release profile to select the optimum system for further clinical investigation. Wafer F6 containing 2:1 sodium alginate to PVP K-25 and 10% glycerol showed optimum properties and was selected for the clinical study. Twenty patients were included in the study and the ketorolac/lidocaine wafer was assessed versus a market product. Visual pain analog was evaluated daily for the first week and wound healing index was evaluated for one week, two weeks and one month following the procedure. The developed ketorolac/lidocaine polymeric wafer proved to be an effective method of reducing pain and discomfort together with enhancing wound healing following gingivectomy.

Hydrogel Containing PEG-Coated Fluconazole Nanoparticles with Enhanced Solubility and Antifungal Activity

“…The surface morphology of plain PEG and FLC-PEG-NPs was examined using SEM instrument operated at 4-25 kV on samples gold-sputtered for 120 s at 10 mA under argon gas and low pressure [15,16].…”

Development of Composition and Technologies of Dental Film with Ketorolac Trometamine

“…Thus, the samples based on alginate (1, 2, 3) had the higher moisture content but the lower tensile than the sample based on xanthan gum (4). Adding of Carbopol 971P NF in the compositions (2,3,5) had different impact on properties of this dosage form -it increased tensile and mucoadhesion for the samples based on xanthan gum and decreased adhesion property and disintegration time for the sample based on alginate. For the alginate Manucol LKX the adding of 0.05 % Carbopol 971P NF in the composition contributed to homogeneously distribution of the substance in the thin film and also made it elasticity.…”

“…Selected polymers have less irritating effect and are biocompatible with mucosal membrane. Using their combinations, it also can be reached the high technology characteristics (tensile, mucoadhesion), are not inferior to polyvinyl alcohol and polyvinylpyrrolidone, which often apply for producing the thin films [3,9]. Furthermore, dental films, keeping the same shape during the exposition for a long time, could cause discomfort among the patients in applying or could be displaced involuntary by movements of the tongue.…”

“…Furthermore, thin films are convenient and harmless to use, and patients can use them themselves. If it is necessary, it possible to remove films from the place of application easily [1][2][3]. The last advantage is significant in terms of consumer preferences in selecting drug delivery system in dental practice.…”

“…Among all these drugs for using in dentistry non-steroidal antiinflammatory drugs play an important role. Pain is the major symptom faced by patients in the process of endodontic treatment in extraction of teeth or part of the gum, after dental implant insertion etc [3][4][5]. Ketorolac is used successfully in dentistry because of strong analgesic effect comparable with narcotic analgesics, but unlike them, ketorolac does not affect at opiate receptors.…”