Mucosal delivery of RNA vaccines by Newcastle disease virus vectors

García‐Sastre, Adolfo

doi:10.1016/j.crimmu.2022.10.001

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…However, sequences within some closely related genetic clades within the same lineage appeared to have overlap when assessed in a two-dimensional ordination. Within the PRRSv data (Figure 2B), the top two ranked amino acid positions (170,172) corresponded well with the classified genetic clades suggesting that these positions may be clade defining mutations. For example, L1A has primarily the EE motif, L1B has EN, and L1C has DG.…”

Section: Using Classlog To Identify Genetic Features Of Biological Re...mentioning

confidence: 71%

Section: Vector Vaccinesmentioning

confidence: 99%

“…Live vaccines can be designed by using viral vectors, such as Newcastle disease virus (NV), Vestibulo stomatitis virus (VSV), and adenoviruses (170)(171)(172). Viral vectors are genetically engineered to express novel antigens, such as the spike protein of the SARS-CoV-2 virus (170)(171)(172)(173). As the LAVs, vector viruses attach and replicate directly on the target mucosal tissue, solving the issues of delivery, dosage, and deposition (174).…”

Section: Vector Vaccinesmentioning

confidence: 99%

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Zoonotic Negative-Sense RNA Viruses

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Using Classlog To Identify Genetic Features Of Biological Re...mentioning

confidence: 71%

Section: Vector Vaccinesmentioning

confidence: 99%

Section: Vector Vaccinesmentioning

confidence: 99%

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Zoonotic Negative-Sense RNA Viruses

2024

Frontiers Research Topics

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“…As part of a further study, the use of rK148/beta-S as an intranasal vaccine and the IgA response in lungs will be evaluated. Unlike the Intramuscular vaccine, the intranasal vaccination can provide mucosal antibodies in the upper respiratory tract, offering protection against infection, blocking virus transmission, and reducing virus invasion of lungs [51] . Hence, the NDV vector vaccine platform shows a promise as a mucosal vaccine that can block infection and transmission through IgA, making it a potential candidate for a wide range of vaccines for respiratory diseases such as RSV, Parainfluenza, Adenovirus, and Influenza.…”

Section: Discussionmentioning

confidence: 99%

Intramuscular administration of recombinant Newcastle disease virus expressing SARS-CoV-2 spike protein protects hACE-2 TG mice against SARS-CoV-2 infection

Kim,

Lee,

Youk

et al. 2023

Vaccine

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“…Various viral vectors, including adenovirus, influenza virus, Newcastle disease virus (NDV), and other paramyxoviruses, have been proposed as vaccine vectors, mainly for parenteral immunizations, but more recently for mucosal ones as well [ 38 ].…”

Section: Mucosal Adjuvants and Delivery Systemsmentioning

confidence: 99%

The Bacterial Spore as a Mucosal Vaccine Delivery System

Saggese

Baccigalupi

Donadio

et al. 2023

IJMS

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The development of efficient mucosal vaccines is strongly dependent on the use of appropriate vectors. Various biological systems or synthetic nanoparticles have been proposed to display and deliver antigens to mucosal surfaces. The Bacillus spore, a metabolically quiescent and extremely resistant cell, has also been proposed as a mucosal vaccine delivery system and shown able to conjugate the advantages of live and synthetic systems. Several antigens have been displayed on the spore by either recombinant or non-recombinant approaches, and antigen-specific immune responses have been observed in animals immunized by the oral or nasal route. Here we review the use of the bacterial spore as a mucosal vaccine vehicle focusing on the advantages and drawbacks of using the spore and of the recombinant vs. non-recombinant approach to display antigens on the spore surface. An overview of the immune responses induced by antigen-displaying spores so far tested in animals is presented and discussed.

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Mucosal delivery of RNA vaccines by Newcastle disease virus vectors

Cited by 6 publications

References 33 publications

Zoonotic Negative-Sense RNA Viruses

Zoonotic Negative-Sense RNA Viruses

Intramuscular administration of recombinant Newcastle disease virus expressing SARS-CoV-2 spike protein protects hACE-2 TG mice against SARS-CoV-2 infection

The Bacterial Spore as a Mucosal Vaccine Delivery System

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