Mucosal Dendritic Cells

Lambrecht, Bart; Iwasaki, Akiko; Kelsall, Brian L.

doi:10.1016/b978-0-12-415847-4.00025-2

Cited by 4 publications

(3 citation statements)

References 509 publications

(715 reference statements)

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“…[109] The epidermis includes many immunocompetent dendritic cells that identify, process, and crosspresent antigens via the major histocompatibility complex-I to CD8+ T lymphocytes. The use of MNs represents an interesting approach [110][111][112] to potentially reduce dendritic cell contribution to the growth and differentiation of lymphocytes, influencing the quantitative nature of the immune response in terms of memory cell formation upon repeated exposure to vaccine-induced pathogens. [111] The potential dose-sparing effects of MNs were demonstrated in a recent investigation where anthrax vaccines were delivered using a MN-based intradermal delivery technique.…”

Section: Microneedles For Drug/molecule Deliverymentioning

confidence: 99%

“…The use of MNs represents an interesting approach [110][111][112] to potentially reduce dendritic cell contribution to the growth and differentiation of lymphocytes, influencing the quantitative nature of the immune response in terms of memory cell formation upon repeated exposure to vaccine-induced pathogens. [111] The potential dose-sparing effects of MNs were demonstrated in a recent investigation where anthrax vaccines were delivered using a MN-based intradermal delivery technique. [113] Low antigen doses delivered via MNs elicited an immune response and antibody levels comparable to those obtained with intramuscular injection.…”

Section: Microneedles For Drug/molecule Deliverymentioning

confidence: 99%

“…The use of MNs represents an interesting approach [ 110–112 ] to potentially reduce dendritic cell contribution to the growth and differentiation of lymphocytes, influencing the quantitative nature of the immune response in terms of memory cell formation upon repeated exposure to vaccine‐induced pathogens. [ 111 ]…”

Section: Microneedle Individual Functionsmentioning

confidence: 99%

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Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Ertas,

Erdem

et al. 2024

Small

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Microneedles (MNs) have maintained their popularity in therapeutic and diagnostic medical applications throughout the past decade. MNs are originally designed to gently puncture the stratum corneum layer of the skin and have lately evolved into intelligent devices with functions including bodily fluid extraction, biosensing, and drug administration. MNs offer limited invasiveness, ease of application, and minimal discomfort. Initially manufactured solely from metals, MNs are now available in polymer‐based varieties. MNs can be used to create systems that deliver drugs and chemicals uniformly, collect bodily fluids, and are stimulus‐sensitive. Although these advancements are favorable in terms of biocompatibility and production costs, they are insufficient for the therapeutic use of MNs. This is the first comprehensive review that discusses individual MN functions toward the evolution and development of smart and multifunctional MNs for a variety of novel and impactful future applications. The study examines fabrication techniques, application purposes, and experimental details of MN constructs that perform multiple functions concurrently, including sensing, drug‐molecule release, sampling, and remote communication capabilities. It is highly likely that in the near future, MN‐based smart devices will be a useful and important component of standard medical practice for different applications.

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Section: Microneedles For Drug/molecule Deliverymentioning

confidence: 99%

Section: Microneedles For Drug/molecule Deliverymentioning

confidence: 99%

Section: Microneedle Individual Functionsmentioning

confidence: 99%

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Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Ertas,

Erdem

et al. 2024

Small

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Mucosal Immunity in Sexually Transmitted Infections

Městecký

Russell

2018

Diagnostics to Pathogenomics of Sexually Transmitted Infections

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Hapten sensitization to vaginal mucosa induces less recruitment of dendritic cells accompanying TGF‐β‐expressing CD206⁺ cells compared with skin

Nakayama

Nishijo

Miyazawa

et al. 2022

Immunity Inflam & Disease

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Introduction: Contact hypersensitivity (CHS), a type of delayed-type hypersensitivity, is induced by hapten exposure to the skin and mucosa. We previously reported that, in a murine model of CHS, the vaginal mucosa (VM) sensitization showed lower T-cell responses as compared with the abdominal skin sensitization. To investigate mechanisms of impaired CHS by the VM sensitization, we compared migration of hapten-captured dendritic cells (DCs) in the draining lymph nodes (dLNs) and recruitment of DCs at the sensitized local sites.Methods: Fluorescein isothiocyanate (FITC) or 2,4-dinitrofluorobenzene (DNFB) was used as hapten, and migration of FITC + DCs in the dLNs and local recruitment of MHC class II + and CD11c + cells were compared between abdominal skin and VM sensitization by flow cytometric analyses and immunohistochemistry. Expression of tumor growth factor (TGF)-β at mRNA and protein levels, and local recruitment of CD206 + cells were examined after VM sensitization.Results: VM sensitization showed less numbers of FITC + MHC class IIhigh CD11c + migratory DCs in the dLNs at 6 and 24 h, as compared with skin sensitization. Both skin and VM sensitization induced the recruitment of dermal/submucosal DCs at 6 h, but the number of submucosal DCs in the VM was significantly decreased at 24 h. VM showed persistently higher mRNA levels of TGF-β2/β3 expression than those of the skin before and after sensitization. In the VM sensitization, increment of CD206 + MHC class II + cells was observed especially at the deep lamina propria at 24 h. Most of CD206 + cells were also positive for the binding to Fc chimeric TGF-β receptor that interacts with all TGF-β isoforms, suggesting TGF-β expression. Conclusion:DC migration to dLNs and localization of DCs at the sensitized sites are limited in the VM sensitization. Our results suggest that the existence

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Mucosal Dendritic Cells

Cited by 4 publications

References 509 publications

Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Mucosal Immunity in Sexually Transmitted Infections

Hapten sensitization to vaginal mucosa induces less recruitment of dendritic cells accompanying TGF‐β‐expressing CD206⁺ cells compared with skin

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Mucosal Dendritic Cells

Cited by 4 publications

References 509 publications

Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Mucosal Immunity in Sexually Transmitted Infections

Hapten sensitization to vaginal mucosa induces less recruitment of dendritic cells accompanying TGF‐β‐expressing CD206+ cells compared with skin

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Product

Resources

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Hapten sensitization to vaginal mucosa induces less recruitment of dendritic cells accompanying TGF‐β‐expressing CD206⁺ cells compared with skin