Mucosal Esophageal Squamous Cell Carcinoma With Intramural Gastric Metastasis Invading Liver and Pancreas: A Case Report

Nakazawa, Nobuaki; Fukuchi, Minoru; Sakurai, Shunsuke; Naitoh, Hiroshi; Kiriyama, Shinsuke; Fukasawa, Tetsuo; Tabe, Yuichi; Yamauchi, Hayato; Suzuki, Masaki; Yoshida, Tatsushi; Kuwano, Hiroyuki

doi:10.9738/intsurg-d-13-00069.1

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…The incidence of IGM is higher in advanced-stage ESCC[ 5 , 22 ], as only a few cases of IGM in the early-stage ESCC have been reported. From mucosal ESCC, to our best knowledge, only 6 cases (including the present one) have been documented[ 10 - 13 , 23 ]. Therefore, although the probability of lymphatic metastasis is very low, it can still occur even if the tumor is confined to the mucosa.…”

Section: Discussionmentioning

confidence: 99%

“…In our case, what really surprised us was that from November 2021 (PET-CT suggested abnormal cardiac metabolism) to November 2022 (gastroendoscopy revealed a Borrmann type II lesion in the cardiac area), metastases to the cardia grew rapidly and were so large that no significant primary lesions were found in the esophagus. The cardiac area is rich in blood supply, which is conducive to the root proliferation of squamous cells, and the cardiac area is significantly large[ 23 , 24 ]. Primary gastric adenocarcinoma sometimes has a similar gross appearance but a higher incidence in the lower part of the stomach.…”

Section: Discussionmentioning

confidence: 99%

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Mucosal esophageal carcinoma following endoscopic submucosal dissection with giant gastric metastasis: A case report and review of literature

Yang,

Sun,

Zhang

2023

World J Gastroenterol

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BACKGROUND Esophageal carcinoma is a highly aggressive digestive cancer responsible for a notable proportion of cancer-related deaths worldwide. Its elevated metastatic rate contributes to a poor prognosis in affected patients. In this case review, we aim to summarize the metastatic characteristics of intramural gastric metastasis (IGM) in mucosal esophageal squamous carcinoma. CASE SUMMARY A 56-year-old man was admitted to our hospital because of a dry cough with an esophageal sensation for one year. Endoscopic examination revealed a 2.0 cm 1.0 cm, superficial esophageal squamous cell carcinoma, and the patient underwent endoscopic submucosal dissection (ESD). Fifteen months after ESD, positron emission tomography/computed tomography revealed that the metabolism of the stomach cardia wall had increased slightly. However, the mucosa of the gastric cardia was smooth under gastroendoscopy. Two years after ESD, endoscopic examination revealed a giant gastric cardia carcinoma, while the esophageal mucosa was smooth, and no advanced cancer was found. A biopsy of the gastric cardia indicated squamous-cell carcinoma. The patient received immunochemotherapy and radiotherapy for esophageal cancer for 8 mo and is currently under follow-up. CONCLUSION Early-stage esophageal carcinoma with IGM is rare. Despite the ESD of the primary lesion, IGM may still occur and should be closely monitored after ESD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mucosal esophageal carcinoma following endoscopic submucosal dissection with giant gastric metastasis: A case report and review of literature

Yang,

Sun,

Zhang

2023

World J Gastroenterol

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“…However, Kato et al reported no marked difference in outcomes between chemotherapy and chemoradiation for patients with gastric IM [ 11 ]. It is generally agreed that gastric IM requires multidisciplinary treatment, including surgery [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Combined treatment with surgery and immune checkpoint inhibitor extended survival in a case of gastric intramural metastasis from esophageal cancer: a case report

et al. 2023

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Background Intramural metastasis (IM) of esophageal cancer is classified as distant metastasis according to the Japanese Classification of Esophageal Cancer, and it is well-known to be associated with a poor prognosis. We herein report a case of perforated gastric IM of esophageal cancer that was successfully controlled with nonradical surgery and subsequent immune checkpoint inhibitor (ICI) treatment. Case presentation A 72-year-old woman was referred to our department for the treatment of esophageal cancer and perforated gastric ulcer. A histological examination of the main tumor and gastric ulcer lesion revealed squamous cell carcinoma. Since the gastric wall tumor had invaded the celiac artery, complete resection was considered impossible. Chemotherapy was administered but led to severe adverse events, so palliative resection was performed. Two months after surgery, computed tomography revealed enlargement of the residual tumor around the celiac artery. However, after nivolumab monotherapy was started, the tumor diminished remarkably, and the quality of life of the patient dramatically improved. Nine months after nonradical surgery, she is surviving without any disease concern. Conclusions With the increased availability of ICIs, multidisciplinary treatment with surgery and ICIs can potentially lead to long-term survival, even in cases expected to have a poor prognosis.

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“…Findings regarding gastrointestinal cancers are summarized in Table 2. [57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72]…”

Section: Gastrointestinal Cancermentioning

confidence: 99%

Metastasis to the stomach: a systematic review

Ibrahimli,

Aliyev,

Majidli

et al. 2023

F1000Res

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Background: This study reviews the literature on gastric metastases (GM) in terms of diagnosis, treatment, and outcomes. The goal of this study was to provide clinicians with a reliable and beneficial source to understand gastric metastases arising from various primary tumors and to present the growing literature in an easily accessible form. Methods: Articles published in English language from implementation of MEDLINE and Cochrane databases until May 2022 were considered for the systematic review. Articles other than English language, letters to the editor, posters, and clinical images were excluded. Hematogenous and lymphogenic metastases were included whereas direct tumoral invasion and seeding were excluded. Articles and abstracts were analyzed and last selection was done after cross-referencing and by use of defined eligibility criteria. Results: In total 1,521 publications were identified and 170 articles were finally included totaling 186 patients with GM. The median age of patients was 62 years. Gynecologic cancer was the most common cancer type causing GM (67 patients), followed by lung cancer (33 patients), renal cancer (20 patients), and melanoma (19 patients). One of the main treatment methods performed for metastasis was resection surgery (n=62), sometimes combined with chemotherapy (ChT) or immunotherapy. ChT was the other most used treatment method (n=78). Also, immunotherapy was amongst the most preferred treatment options after surgery and ChT (n=10). Conclusions: As 172 case reports were screened in the systematic review from different journals, heterogeneity was inevitable. Some articles missed important information such as complete follow-up or clinical information. Moreover, since all of the included articles were case reports quality assessment could not be performed. Among 172 case reports reviewed, resection surgery was performed the most and was sometimes combined with ChT and immunotherapy. Further research about what type of treatment has the best outcomes for patients with gastric metastases is needed.

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Mucosal Esophageal Squamous Cell Carcinoma With Intramural Gastric Metastasis Invading Liver and Pancreas: A Case Report

Cited by 4 publications

References 13 publications

Mucosal esophageal carcinoma following endoscopic submucosal dissection with giant gastric metastasis: A case report and review of literature

Mucosal esophageal carcinoma following endoscopic submucosal dissection with giant gastric metastasis: A case report and review of literature

Combined treatment with surgery and immune checkpoint inhibitor extended survival in a case of gastric intramural metastasis from esophageal cancer: a case report

Metastasis to the stomach: a systematic review

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