Mucosal expression of matrix metalloproteinases and their tissue inhibitors in ulcerative colitis patients

Kusugami, Kazuo; Nobata, Kazuo; Tsuzuki, Tomoyuki; Ando, Takafumi; Ina, Kenji

doi:10.1007/s005350300075

Cited by 4 publications

(5 citation statements)

References 12 publications

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“…[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Angiogenesis plays an important role in a wide range of physiological processes including embryogenesis, wound healing, growth of solid tumor, and rheumatoid arthritis. [3][4][5]21,29,30 It is thought that angiogenesis is regulated by a balance of angiogenic factors and angiogenesis inhibitors.…”

Section: Discussionmentioning

confidence: 99%

“…2 In this context, angiogenesis plays an important role as a protective factor in regeneration of injured tissues, [3][4][5] and investigations focused on several angiogenic factors in IBD have been increasing. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Numerous angiogenic factors have been identified to date. Among them, vascular endothelial growth factor (VEGF) is thought to play a principal role by stimulating migration and proliferation of endothelial cells (ECs) and the expression of angiogenesis-related genes.…”

Section: Introductionmentioning

confidence: 99%

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Altered expression of angiogenic factors in the VEGF-Ets-1 cascades in inflammatory bowel disease

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered expression of angiogenic factors in the VEGF-Ets-1 cascades in inflammatory bowel disease

et al. 2004

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“…Disturbance in the balance between the synthesis and breakdown of ECM components is involved in the pathological findings of IBD, leading to progressive tissue destruction (e.g. ulcers and fistulas) or excessive deposition of collagens (major component of ECM) resulting in fibrosis (2). Matrix metalloproteinases (MMPs) and their inhibitors and growth factors are important players in this tissue remodeling process.…”

mentioning

confidence: 99%

Infliximab Restores the Dysfunctional Matrix Remodeling Protein and Growth Factor Gene Expression in Patients with Inflammatory Bowel Disease

Bruyn

Machiels²,

Vandooren

et al. 2014

Inflammatory Bowel Diseases

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“…of collagens, finally causing ulcers, fistulas and fibrosis (16), MMPs are key in the intestinal tissue remodeling process (17). In addition, their upregulation may lead to patients with CD not responding to anti-TNFα therapy (18).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive bioinformatics analyses of Crohn's disease

Zhou

Zhan

Huang

et al. 2017

Molecular Medicine Reports

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Crohn's disease (CD) is a chronic, relapsing inflammatory disease with increasing incidence and prevalence worldwide. In previous years, the accumulation of microarray data has provided us an approach to obtain further insight into CD. In the present study, the microarray data of CD was comprehensively analyzed using multiple bioinformatics methods, and the pathobiological process of the disease was examined. Gene expression data from colon tissues of patients with CD were obtained from the Gene Expression Omnibus database; following which differentially expressed genes were identified between CD and control sample groups. Subsequently, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to investigate which functions and pathways in which the differentially expressed genes enriched. TargetScan and miRDB databases were then used to predict which microRNAs (miRNAs) regulated the differentially expressed genes. As a result, a total of 432 differentially expressed genes, including 229 upregulated and 203 downregulated genes, including matrix metallopeptidase 3 and glutathione S‑transferase α1, were identified in CD samples. These differentially expressed genes were significantly involved in regulation of the inflammatory response, innate immune response, cell migration, extracellular matrix organization, Janus kinase/signal transducers and activators of transcription signaling pathway, and cytokine‑cytokine receptor interaction. The miRNA-gene network showed that miR‑149‑3p and miR‑4447 regulated the most differentially expressed genes. These findings extend current understanding of the mechanisms underlying CD, and the differentially expressed genes and regulator miRNAs identified may be used as potential biomarkers and therapeutic targets for CD.

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Mucosal expression of matrix metalloproteinases and their tissue inhibitors in ulcerative colitis patients

Cited by 4 publications

References 12 publications

Altered expression of angiogenic factors in the VEGF-Ets-1 cascades in inflammatory bowel disease

Altered expression of angiogenic factors in the VEGF-Ets-1 cascades in inflammatory bowel disease

Infliximab Restores the Dysfunctional Matrix Remodeling Protein and Growth Factor Gene Expression in Patients with Inflammatory Bowel Disease

Comprehensive bioinformatics analyses of Crohn's disease

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