1981
DOI: 10.1152/ajpgi.1981.240.6.g442
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Mucosal gastrin receptor. VI. Induction by corticosterone in newborn rats

Abstract: Serum and antral gastrin levels as well as specific binding of [125I]gastrin-17 to a 270-30,000 g oxyntic gland mucosa crude membrane preparation were measured in rats between 5 and 40 days of age. Rats were normally weaned at day 18, although weaning was prevented in some animals until day 25. The results of these studies confirmed our previous data showing that mucosal gastrin receptors and antral gastrin levels begin to increase at the time of normal weaning and reach adult levels within a few days. Althoug… Show more

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Cited by 32 publications
(33 citation statements)
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“…In the present work, we used hydrocorti sone acetate which is similar in activity to corticosterone but is longer acting [9], Three different doses of hydrocortisone were stud ied, two pharmacological and one which has been previously considered to be in a physi ological range [10][11][12], It should be pointed out that the highest dose of hydrocortisone was used only in order to check whether it would increase the antral gastrin content in suckling rats as previously reported with such high doses [8]. Hydrocortisone-treated rats gained weight during treatment, how ever, their body weight was lesser than that of their saline counterparts at the end of treatment.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In the present work, we used hydrocorti sone acetate which is similar in activity to corticosterone but is longer acting [9], Three different doses of hydrocortisone were stud ied, two pharmacological and one which has been previously considered to be in a physi ological range [10][11][12], It should be pointed out that the highest dose of hydrocortisone was used only in order to check whether it would increase the antral gastrin content in suckling rats as previously reported with such high doses [8]. Hydrocortisone-treated rats gained weight during treatment, how ever, their body weight was lesser than that of their saline counterparts at the end of treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, bombesin [1,2] and epidermal growth factor [3][4][5] have been reported to stimulate the oxyntic mucosal growth in un weaned rats, and bombesin to stimulate that of the antral mucosa [2], Glucocorticoids also seem to play a major role before the weaning period. Indeed, in the very young rat, from the perinatal period until weaning (around the 20th day of life), high doses (up to 250 mg/kg) of hydrocortisone or cortico sterone, the natural corticosteroid hormone of the rat, induce a precocious differentia tion of gastric chief cells [6], increase basal acid output [7], and stimulate certain intesti nal enzyme activities [8], They also induce a premature appearance of gastrin receptors [9] and noticeably augment antral gastrin levels [8,9], However, using biochemical methods, it has been reported that glucocor ticoid treatment during development does not affect the gastric mucosal DNA content in the rat [7] nor the gastric DNA synthesis in the mouse [4] while it induces a decrease in mucosal cell proliferation in the colon of rat pups [10], On the whole, it appears that the main effect of glucocorticoids is maturation of the gastrointestinal functional activities rather than stimulation of cell growth, although few works have dealt with the latter point. So, the current study examines the influence of a 6-day administration of hydrocortisone on the development of the gastric mucosa and some gastric cell populations in suckling rats using histological quantitative and morpho metric methods.…”
mentioning
confidence: 99%
“…17,18) Moreover, glucocorticoid triggers the appearance of gastrin receptors in the rat gastric mucosa and a significant increase in antral gastrin. 19) Glucocorticoid stimulates the maturation of H,K-ATPase in the infant rat stomach. 20) Therefore, we compared the effects of hydrocortisone on the expression of MUC5AC and PgC mRNA in the rat gastric mucosa.…”
Section: Discussionmentioning
confidence: 99%
“…In the rat, mucosal gastrin receptors appear at the normal time for weaning, even if weaning to solid chow is artificially delayed. In fact, the appearance of mucosal gastrin receptors in the rat, like many other changes in rat gastrointestinal function, appears to be mediated by adrenal corticosteroids (26). Whether gastrin receptors in neonatal canine LES, gastric muscle, and oxyntic gland are induced by corticosteroids is unknown, but such an-hypothesis may be drawn from the rodent studies to account for these observations in the beagle.…”
Section: Discussionmentioning
confidence: 99%