Mucosal immunization of calves with recombinant bovine adenovirus-3: induction of protective immunity to bovine herpesvirus-1.

Zakhartchouk, Alexander N.; Pyne, Caron; Mutwiri, George; Papp, Zsuzsánna; Baca-Estrada, Maria E.; Griebel, Philip; Babiuk, Lorne A.; Tikoo, Suresh K.

doi:10.1099/0022-1317-80-5-1263

Cited by 63 publications

(47 citation statements)

References 25 publications

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“…Several subunit vaccines were tested. They consist mainly of glycoproteins B, C or D expressed in different systems such as transfected cell cultures [204], recombinant baculoviruses [203], recombinant adenoviruses [60,62,163,226], or recombinant tobacco mosaïc virus [157]. The gD based subunit vaccines are the most efficacious at reducing clinical disease and virus excretion when they are formulated with effective adjuvants.…”

Section: New Trends In Bohv-1 Vaccinesmentioning

confidence: 99%

Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis

et al. 2007

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-Bovine herpesvirus 1 (BoHV-1), classified as an alphaherpesvirus, is a major pathogen of cattle. Primary infection is accompanied by various clinical manifestations such as infectious bovine rhinotracheitis, abortion, infectious pustular vulvovaginitis, and systemic infection in neonates. When animals survive, a life-long latent infection is established in nervous sensory ganglia. Several reactivation stimuli can lead to viral re-excretion, which is responsible for the maintenance of BoHV-1 within a cattle herd. This paper focuses on an updated pathogenesis based on a molecular characterization of BoHV-1 and the description of the virus cycle. Special emphasis is accorded to the impact of the latency and reactivation cycle on the epidemiology and the control of BoHV-1. Several European countries have initiated BoHV-1 eradication schemes because of the significant losses incurred by disease and trading restrictions. The vaccines used against BoHV-1 are described in this context where the differentiation of infected from vaccinated animals is of critical importance to achieve BoHV-1 eradication.

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Section: New Trends In Bohv-1 Vaccinesmentioning

confidence: 99%

Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis

et al. 2007

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“…One of our earlier observations that recombinant bovine adenovirus vaccine vectors had a tropism for PMNs triggered an interest in determining the role of PMNs in the induction of a specific immune response. As bovine adenoviral vectors can stimulate strong immune reactions [16], we tested the hypothesis that bovine PMNs might function as antigen-presenting cells (APCs), thereby providing a link between the innate and adaptive branches of the immune system. As there was a growing body of literature to suggest that PMNs from other species could assume such a role, we began by investigating the expression of MHC class II, a key protein involved in antigen presentation, on bovine PMNs.…”

Section: Introductionmentioning

confidence: 99%

Bovine polymorphonuclear cells passively acquire membrane lipids and integral membrane proteins from apoptotic and necrotic cells

Whale

Beskorwayne

Babiuk

et al. 2006

Journal of Leukocyte Biology

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Immune cells can acquire membrane fragments and integral membrane proteins from dead and dying cells or in the case of immature dendritic cells, from live cells. While investigating the possibility that bovine polymorphonuclear cells (PMNs) might present antigen, coculture assays confirmed that integral membrane proteins were transferred rapidly and efficiently to bovine PMNs from a variety of apoptotic and necrotic cells. Specifically, we observed that PMNs rapidly acquired proteins such as major histocompatibility complex (MHC) class II and CD3 from a variety of syngeneic, allogeneic, and xenogeneic cell types. Such acquisition occurred within 40 min of PMN coculture with isolated peripheral blood mononuclear cells, and this acquisition occurred with equal efficiency at 4 degrees C and 37 degrees C. The transfer of murine MHC class II to bovine PMNs precluded the possibility of endogenous protein expression. We also demonstrated the transfer of fluorescently labeled plasma membrane lipids and biotinylated integral membrane proteins. Collectively, these observations support the hypothesis that membrane protein transfer was mediated by the fusion of membrane fragments or microvesicles with the PMN plasma membrane and not by phagocytosis of cell fragments. These observations indicate that phenotypic studies of PMNs must consider circumstances whereby PMNs may passively acquire membrane lipids and a variety of integral membrane proteins from dead or dying cells.

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“…Many vector vaccines have been developed for the poultry industry, based on pox virus, herpesvirus, or adenovirus (80). A BHV1 deletion mutant and bovine adenovirus-3 have also been described as vector and found to induce protective immunity in cattle (75,103). There is some evidence that incorporation of the G protein of BRSV enhances the virulence of a gE-deleted BHV1 vector (85).…”

Section: Replicating Vector Vaccinesmentioning

confidence: 97%

Vaccinology: Present and future of veterinary viral vaccinology: A review

Oirschot¹

2001

Veterinary Quarterly

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This review deals briefly with some key developments in veterinary vaccinology, lists the types of vaccines that are used for vaccinations commonly performed in food animals as well as in companion animals, and indicates that the practising veterinarian can select the best vaccine by comparing the results of efficacy studies. Diva (Differentiating Infected from Vaccinated Animals; also termed marker) vaccines and companion diagnostic tests have been developed that can be used for progammes aimed to control or eradicate virus infections. Vaccine-induced herd immunity, which can be measured relatively easily when diva vaccines are used, is a crucial issue in such programmes. Current vaccine research follows many routes towards novel vaccines, which can be divided into non-replicating ('killed') and replicating ('live') vaccines. Promising trends are the development of DNA vaccination, vector vaccines, and attenuation of DNA and RNA viruses by DNA technology. The lack of (in vitro) correlates of vaccine protection markedly hampers progress in vaccine research. Various characteristics of an 'ideal' vaccine are listed, such as multivalency and the induction of lifelong immunity after one non-invasive administration in animals with maternal immunity. Future research should be aimed at developing vaccines that approach the ideal as closely as possible and which are directed against diseases not yet controlled by vaccination and against newly emerging diseases.

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Mucosal immunization of calves with recombinant bovine adenovirus-3: induction of protective immunity to bovine herpesvirus-1.

Cited by 63 publications

References 25 publications

Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis

Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis

Bovine polymorphonuclear cells passively acquire membrane lipids and integral membrane proteins from apoptotic and necrotic cells

Vaccinology: Present and future of veterinary viral vaccinology: A review

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