Mucosal iodine staining improves endoscopic visualization of squamous dysplasia and squamous cell carcinoma of the esophagus in linxian, china

Dawsey, Sanford M.; Fleischer, David E.; Wang, Guo‐Qing; Zeng, Bin; Kidwell, Jean; Lü, Ning; Lewin, Klaus J.; Roth, Mark J.; Tio, T. Lok; Taylor, Philip R.

doi:10.1002/(sici)1097-0142(19980715)83:2<220::aid-cncr4>3.3.co;2-o

Cited by 68 publications

(105 citation statements)

References 29 publications

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“…Therefore, lightly stained and unstained esophageal lesions are not exclusive to esophageal cancer. Our results showed that the accuracy of lugol's lightly stained and unstained for identifying CAPs was only 67.4% (140/356), which is consistent with Dawsey et al [7]. Lightly stained lesions with iodine were more difficult to distinguish esophageal squamous cell CAPs from NCNPs: in our 204 lightly stained lesions, there were 88 CAPs and 116 NCNPs.…”

Section: Discussionsupporting

confidence: 91%

“…In particular, chromoendoscopy with lugol's solution significantly improves the early detection of esophageal CAPs [2][3][4][5][6]. Dye endoscopy by lugol's solution can make the presence and extent of esophageal lesions more clear, which is helpful in diagnosing early CAPs but its specificity is quite low [7]. Therefore, it is essential to develop new methods for detecting esophageal CAPs with a higher specificity.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of double vital staining with lugol's iodine and methylene blue in diagnosing superficial esophageal lesions

Peng

Long

et al. 2010

Scandinavian Journal of Gastroenterology

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Evaluation of double vital staining with lugol's iodine and methylene blue in diagnosing superficial esophageal lesions

Peng

Long

et al. 2010

Scandinavian Journal of Gastroenterology

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“…These methods typically involve relatively low trauma and are relatively inexpensive. Moreover, endoscopy with iodine staining has sufficient sensitivity and specificity for detecting EC and precursor lesions 15. However, endoscopy is expensive and may cause severe side effects such as perforation, cardiopulmonary events, iodine allergy, bleeding and potential psychological harm 25.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of endoscopic screening for esophageal cancer in China (ESECC): design and preliminary results of a population-based randomised controlled trial

Liu

et al. 2018

Gut

134

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“…One observational study indicated that iodine chromoendoscopy improved lesion delineation in 88% of cases involving oesophageal HGD or SCC 85. Expert endoscopists proposed that iodine chromoendoscopy is indispensable for the accurate delineation of oesophageal SCCs, enabling the borders of the lesion to be accurately established before endoscopic treatment 86 87.…”

Section: Consensus Statementsmentioning

confidence: 99%

An Asian consensus on standards of diagnostic upper endoscopy for neoplasia

Chiu

Uedo²,

Singh

et al. 2018

Gut

123

103

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BackgroundThis is a consensus developed by a group of expert endoscopists aiming to standardise the preparation, process and endoscopic procedural steps for diagnosis of early upper gastrointestinal (GI) cancers.MethodThe Delphi method was used to develop consensus statements through identification of clinical questions on diagnostic endoscopy. Three consensus meetings were conducted to consolidate the statements and voting. We conducted a systematic literature search on evidence for each statement. The statements were presented in the second consensus meeting and revised according to comments. The final voting was conducted at the third consensus meeting on the level of evidence and agreement.ResultsRisk stratification should be conducted before endoscopy and high risk endoscopic findings should raise an index of suspicion. The presence of premalignant mucosal changes should be documented and use of sedation is recommended to enhance detection of superficial upper GI neoplasms. The use of antispasmodics and mucolytics enhanced visualisation of the upper GI tract, and systematic endoscopic mapping should be conducted to improve detection. Sufficient examination time and structured training on diagnosis improves detection. Image enhanced endoscopy in addition to white light imaging improves detection of superficial upper GI cancer. Magnifying endoscopy with narrow-band imaging is recommended for characterisation of upper GI superficial neoplasms. Endoscopic characterisation can avoid unnecessary biopsy.ConclusionThis consensus provides guidance for the performance of endoscopic diagnosis and characterisation for early gastric and oesophageal neoplasia based on the evidence. This will enhance the quality of endoscopic diagnosis and improve detection of early upper GI cancers.

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Mucosal iodine staining improves endoscopic visualization of squamous dysplasia and squamous cell carcinoma of the esophagus in linxian, china

Cited by 68 publications

References 29 publications

Evaluation of double vital staining with lugol's iodine and methylene blue in diagnosing superficial esophageal lesions

Evaluation of double vital staining with lugol's iodine and methylene blue in diagnosing superficial esophageal lesions

Efficacy of endoscopic screening for esophageal cancer in China (ESECC): design and preliminary results of a population-based randomised controlled trial

An Asian consensus on standards of diagnostic upper endoscopy for neoplasia

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