Mucosal leishmaniasis in the Sudan

Milošev, B.; Daoud, E. H.; Hadi, A. El; Hassan, A.M. El; Sati, Mohammed Hamad

doi:10.1080/00034983.1969.11686607

Cited by 20 publications

(6 citation statements)

References 8 publications

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“…These studies describe a cohort of CL patients over a certain period, ranging from two to nine years. Chronologically, 10 studies reported CL cases in periods before 1980 [ 41 , 45 , 47 , 52 , 74 , 76 – 80 ], 11 described patient groups observed between 1980–2000 [ 35 , 57 , 59 , 67 , 69 , 81 – 87 ], and seven between 2000 and 2013 [ 58 , 60 , 88 – 92 ].…”

Section: Resultsmentioning

confidence: 99%

“…The higher proportion of complicated or atypical lesions are frequently reported from teaching hospitals or specialized services. This includes sporotrichoid CL with painless subcutaneous nodules along the lymphatic vessels in Sudan [ 80 , 87 ], or the diffuse CL in Ethiopia, which appear pseudo-lepromatous and can result in fungating or tumor-like lesions [ 52 , 80 ].…”

Section: Resultsmentioning

confidence: 99%

“…In the case of DCL, spontaneous cure almost never happens. Mucocutaneous leishmaniasis is rare in Africa, but cases have been reported from Sudan and Ethiopia [ 52 , 80 , 100 ]. The lesions tend to be infiltrative and result in chronic edematous inflammation involving the lips, nose, buccal mucosa and larynx are.…”

Section: Resultsmentioning

confidence: 99%

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Uncharted territory of the epidemiological burden of cutaneous leishmaniasis in sub-Saharan Africa—A systematic review

et al. 2018

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IntroductionCutaneous leishmaniasis (CL) is the most frequent form of leishmaniasis, with 0.7 to 1.2 million cases per year globally. However, the burden of CL is poorly documented in some regions. We carried out this review to synthesize knowledge on the epidemiological burden of CL in sub-Saharan Africa.MethodsWe systematically searched PubMed, CABI Global health, Africa Index Medicus databases for publications on CL and its burden. There were no restrictions on language/publication date. Case series with less than ten patients, species identification studies, reviews, non-human, and non-CL focused studies were excluded. Findings were extracted and described. The review was conducted following PRISMA guidelines; the protocol was registered in PROSPERO (42016036272).ResultsFrom 289 identified records, 54 met eligibility criteria and were included in the synthesis. CL was reported from 13 of the 48 sub-Saharan African countries (3 eastern, nine western and one from southern Africa). More than half of the records (30/54; 56%) were from western Africa, notably Senegal, Burkina Faso and Mali. All studies were observational: 29 were descriptive case series (total 13,257 cases), and 24 followed a cross-sectional design. The majority (78%) of the studies were carried out before the year 2000. Forty-two studies mentioned the parasite species, but was either assumed or attributed on the historical account. Regional differences in clinical manifestations were reported. We found high variability across methodologies, leading to difficulties to compare or combine data. The prevalence in hospital settings among suspected cases ranged between 0.1 and 14.2%. At the community level, CL prevalence varied widely between studies. Outbreaks of thousands of cases occurred in Ethiopia, Ghana, and Sudan. Polymorphism of CL in HIV-infected people is a concern. Key information gaps in CL burden here include population-based CL prevalence/incidence, risk factors, and its socio-economic burden.ConclusionThe evidence on CL epidemiology in sub-Saharan Africa is scanty. The CL frequency and severity are poorly identified. There is a need for population-based studies to define the CL burden better. Endemic countries should consider research and action to improve burden estimation and essential control measures including diagnosis and treatment capacity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Uncharted territory of the epidemiological burden of cutaneous leishmaniasis in sub-Saharan Africa—A systematic review

et al. 2018

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“…In Italy 10 cases of mucosal leishmaniasis have been reported [10]: the present case is the first to be documented of isolated laryngeal leishmaniasis and the second case described in an immunocompetent host [13].…”

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confidence: 94%

“…A few reports have indicated that L. donovani [4][5][6][7][8][9], as well as L. infantum [10][11][12][13][14], may cause localized mucosal disease in the absence of concomitant visceral or cutaneous leishmaniasis.…”

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confidence: 99%