Mucosal melanoma of the head and neck

Ascierto, Paolo A.; Accorona, Remo; Botti, Gerardo; Farina, Davide; Fossati, Piero; Gatta, Gemma; Gogas, Helen; Lombardi, Davide; Maroldi, Roberto; Nicolai, Piero; Ravanelli, Marco; Vanella, Vito

doi:10.1016/j.critrevonc.2017.01.019

Cited by 145 publications

(230 citation statements)

References 139 publications

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“…Treatment options for localized lesions include surgical treatment and radiation therapy. Surgery is still considered the most effective treatment for mucosal melanomas . In contrast, adjuvant postoperative radiation therapy may improve locoregional control but does not appear to affect survival .…”

Section: Discussionmentioning

confidence: 99%

“…Although mucosal melanomas are known to be radioresistant, a recent retrospective multicenter study showed that carbon ion radiation therapy resulted in good local control and overall survival with acceptable toxicities . Complete surgical excision with clear margins is one of the most important prognostic factors . However, wide surgical excision is often difficult because of anatomical complexity and proximity to vital structures …”

Section: Discussionmentioning

confidence: 99%

“…Mucosal melanomas are rare aggressive cancers of mucosal surfaces with clinical and pathological characteristics distinct from cutaneous melanomas, warranting different treatment approaches . Mucosal melanomas are often invasive when diagnosed and have a very high propensity to relapse, which are associated with a poor prognosis …”

Section: Introductionmentioning

confidence: 99%

“…New treatment options have been developed and approved for patients with advanced melanoma. Immunotherapies, such as monoclonal antibodies, which target cytotoxic T‐lymphocyte‐associated molecule‐4, ipilimumab and the programmed death (PD)‐1/PD‐ligand 1 pathway inhibitors, nivolumab and pembrolizumab, are treatment options for unresectable or metastatic lesions …”

Section: Introductionmentioning

confidence: 99%

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Synergistic effects of interferon‐beta and nivolumab in oral mucosal melanoma

Fusumae

Chiang

Okada

et al. 2017

The Journal of Dermatology

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Mucosal melanoma is a rare aggressive cancer with a very poor prognosis. Clinical and pathological characteristics of mucosal melanoma differ from those of cutaneous melanoma and there are no established management guidelines for mucosal melanoma. Complete surgical excision is one of the most effective treatments for localized lesions, while targeted therapies and immunotherapies, such as monoclonal antibodies that target cytotoxic T-lymphocyte-associated molecule-4, and the programmed death (PD)-1/PD-ligand 1 pathway inhibitors, are treatment options for unresectable or metastatic lesions. Here, we describe the case of a patient with oral mucosal melanoma with multiple metastases. In our case, local injection of interferon (IFN)-b with dacarbazine-nimustinevincristine therapy provided antitumor effects on an invasive tumor on the upper gingiva. Nivolumab therapy produced complete remission of lymph node and bone metastases. In contrast, the remaining in situ portion of oral mucosal melanoma on the hard palate was refractory to IFN-b monotherapy and nivolumab therapy. However, after administration of nivolumab, peritumoral injection of IFN-b showed rapid therapeutic effects. Our case suggested that nivolumab upregulated the antitumor effects of IFN-b, which induced the recruitment of CD8 + T cells into the tumor microenvironment contributing to the deletion of tumor cells. Combination therapy of IFN-b and nivolumab may be a potential treatment option for patients with oral mucosal melanoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synergistic effects of interferon‐beta and nivolumab in oral mucosal melanoma

Fusumae

Chiang

Okada

et al. 2017

The Journal of Dermatology

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“…Clinical examination by fiberscopic or endoscopic investigation is useful, but they cannot appreciate the extent of the disease or guide towards a diagnosis. In some cases, multiple lesions (for instance, satellite lesions) can be frequently observed, even centimetres away from the main tumor, with spreading occurring along the mucosal/submucosal planes 16 . Macroscopically, the tumor was reddish-crimson, covered by greyish exudates and very friable, which consists in the fact that one third of mucosal melanomas are achromic 17 .…”

Section: Discussionmentioning

confidence: 99%

Primary sinonasal mucosal melanoma – Case report and literature review

Evsei

Birceanu-Corobea

Melinte

et al. 2017

Romanian Journal of Rhinology

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BACKGROUND. Primary sinonasal mucosal melanoma is a rare tumor with a poor survival rate. There is an inherent difficulty in diagnosing these lesions, especially because their complex anatomic locations and symptoms can be frequently confused with other benign or malignant processes. The purpose of our study was to report a difficult case and review the literature and recent research on therapeutic modalities. MATERIAL AND METHODS. We herein report a 61-year-old female patient, with a history of right eye enucleation and prosthesis, who presented with obstruction of the left nostril, anterior and posterior mucopurulent rhinorrhea, anosmia, left facial numbness, left exophthalmia accompanied by ipsilateral epiphora and decreased visual acuity. RESULTS. Clinical and imagistic testing revealed a large, grayish, fleshy tumor localized in the left maxillary sinus, with extension to the left orbit (producing osteolysis of the inferior and medial orbital walls), nasopharynx, ethmoidal cells and left frontal sinus. Pathological and immunohistochemical examination confirmed the diagnosis of mucosal melanoma. Other primary sites were excluded. The patient succumbed shortly after, following only palliative treatment. CONCLUSION. Early diagnosis of primary sinonasal mucosal melanoma is essential but very difficult to detect. Any symptoms such as unilateral epistaxis or nasal obstruction in a patient over the age of 60 should be rendered suspicious. Pathological and immunohistochemical examination for diagnosis and prognostic factors are important. Although surgery is the first option for treatment, one must consider, according to tumor staging, radiotherapy and chemotherapy with immunotherapy as a viable course of treatment for advanced cases.

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