Mucosal Melanoma of the Head and Neck: A Systematic Review of the Literature

Lazarev, Stanislav; Gupta, Vishal; Hu, K.; Harrison, Louis B.; Bakst, Richard L.

doi:10.1016/j.ijrobp.2014.03.042

Cited by 103 publications

(116 citation statements)

References 63 publications

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“…The mixed type is most ed cells in the seromucinous glands. Most prior studies have not described pigmented cells in the seromucous glands as seen in our case [15][16][17][18][19][20][21]. The luminal lining cells contained not only melanin pigment (positive Fontana-Masson reaction) but also were immunoreactive for HMB-45, S-100 protein and melan A suggesting the production of melanin in these cells.…”

Section: Discussionmentioning

confidence: 50%

“…Mucosal melanomas are rare and are reported to have a more aggressive behavior than their cutaneous counterparts [12][13][14][15][16][17]. Sinonasal melanomas appear to be the most common of the head and neck mucosal melanomas [12,18].…”

Section: Discussionmentioning

confidence: 99%

“…Unlike cutaneous melanoma, sinonasal melanomas tend to be BRAF mutation negative but show mutations in KIT [16,17,20].…”

Section: Pathologic Findingsmentioning

confidence: 99%

See 2 more Smart Citations

Malignant Melanoma Arising in Association with Sinonasal Melanosis: A Case Report and Review of the Literature

Ewing¹

2017

Int J Pathol Clin Res

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

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Malignant Melanoma Arising in Association with Sinonasal Melanosis: A Case Report and Review of the Literature

Ewing¹

2017

Int J Pathol Clin Res

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“…[7][8][9] Clinical. With an equal sex distribution, there is a wide age range but more common in elderly (7th decade) patients (Table 2).…”

Section: Melanomamentioning

confidence: 99%

“…With an equal sex distribution, there is a wide age range but more common in elderly (7th decade) patients (Table 2). 7,9 Symptoms are non-specific, with melanorrhea (black flecked secretions) uncommon. A mass usually affects the sinonasal cavity (septum) more often than the paranasal sinuses.…”

Section: Melanomamentioning

confidence: 99%

Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach

Thompson

2017

Modern Pathology

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One of the most challenging diagnostic categories within tumors of the sinonasal tract is the small round blue cell tumors. Biopsies are usually small and limited, resulting in considerable diagnostic difficulty for practicing surgical pathologists. These tumors share several overlapping histologic and immunophenotypic findings while also showing considerable variation within and between cases. Specific tumor site of origin, imaging findings, and clinical findings must be combined with the histology and pertinent ancillary studies if the correct diagnosis is to be reached. Discrimination between neoplasms is critical as there are significant differences in therapy and overall outcome. It is important to have a well developed differential diagnosis for this category of tumors, where each of the diagnoses is considered, evaluated, and either confirmed or excluded from further consideration. In an undifferentiated tumor, showing a small round blue cell morphology, using the mnemonic 'MR SLEEP' helps to highlight tumors to consider: melanoma, mesenchymal chondrosarcoma, rhabdomyosarcoma, sinonasal undifferentiated carcinoma, squamous cell carcinoma (including NUT carcinoma), small cell osteosarcoma, lymphoma, esthesioneuroblastoma (olfactory neuroblastoma), Ewing sarcoma/primitive neuroectodermal tumor, pituitary adenoma, and plasmacytoma. A panel of pertinent immunohistochemistry studies, histochemistries and/or molecular tests should aid in reaching a diagnosis, especially when taking the pattern and intensity of reactions into consideration.

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Comparing endoscopic resection and open resection for management of sinonasal mucosal melanoma

Farber

Bavier

Crippen

et al. 2019

Int Forum Allergy Rhinol

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Background: Sinonasal mucosal melanoma (SMM) is a rare, aggressive cancer, optimally managed with complete surgical resection. This study aimed to assess the impact of surgical approach on outcomes by comparison of cases managed with open vs endoscopic resection. Methods:The National Cancer Database 2010-2015 datasets were queried for all cases of non-metastatic SMM initially managed with definitive surgery. Patients were grouped according to surgical approach (open vs endoscopic) and compared for patient, tumor, and treatment variables using chi-square analyses. Case-control matching was used to generate subgroups of cases paired 1:1 between groups, matched for significantly distributed variables. Subgroups were compared for perioperative outcomes and overall survival (OS) using Kaplan-Meier analyses. Results:Of the 686 cases of SMM managed with definitive surgery, 46.2% were treated endoscopically. Open and endoscopic groups did not differ significantly by T-stage, primary site, or rates of adjuvant therapies. Case-control matching for these variables generated a subpopulation of 240 paired cases. Comparison of matched groups found no significant differences in 30-day or 90-day mortality. Endoscopically managed patients had higher rates of unplanned readmission whereas open resection patients had longer length of stay (LOS). There was no significant difference in OS between groups. Conclusion:In surgically managed SMM, open resection patients have significantly longer LOS, whereas endoscopic patients have higher rates of unplanned readmission. Surgical approach does not appear to influence OS. C 2019 ARS-AAOA, LLC.

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Mucosal Melanoma of the Head and Neck: A Systematic Review of the Literature

Cited by 103 publications

References 63 publications

Malignant Melanoma Arising in Association with Sinonasal Melanosis: A Case Report and Review of the Literature

Malignant Melanoma Arising in Association with Sinonasal Melanosis: A Case Report and Review of the Literature

Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach

Comparing endoscopic resection and open resection for management of sinonasal mucosal melanoma

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