Mucosal Melanoma of the Oral Cavity: What is the Role of Elective Neck Dissection?

Haimowitz, Sean; Cohen, David; Dhanda, Aatin K; Barron, Kendyl; Povolotskiy, Roman; Roden, Dylan F.

doi:10.1002/lary.30152

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…In a systematic review of 25 patients with primary gastric melanoma, six had metastatic disease, and their 5-year survival rate was <5 percent. 14 Furthermore, ICI treatment only increased the 5-year overall survival rate to 25 percent, 15…”

Section: Discussionmentioning

confidence: 99%

A Curious Case of Primary Gastric Mucosal Melanoma

Sohail,

Samar,

Qureshi

et al. 2024

Korean J Gastroenterol

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Malignant melanoma is a neoplasm of melanin-producing cells predominantly of cutaneous origin, which uncommonly develops within gut mucosa. We present the case of a 58-year-old woman with complaints of abdominal pain, loss of appetite and weight. Esophagogastroduodenoscopy revealed a gastric mass and systemic imaging demonstrated widespread nodal and bilateral adrenal gland involvement. Histopathology of the gastric mass confirmed primary malignant mucosal melanoma of the stomach. The patient received three cycles of Nivolumab but did not respond, and thus, was then offered best supportive care. Although infrequent, mucosal melanoma can arise from the gastrointestinal tract, and in contrast to the cutaneous form, advanced disease usually has a dismal prognosis and responds poorly to immune checkpoint inhibitors. Primary gastric melanoma is an aggressive disease that is diagnosed by exclusion after the differential diagnosis of metastasis from a cutaneous or unknown primary site has been conducted. If available, patients with treatment-naïve mucosal melanoma should be considered for enrollment in clinical trials.

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Section: Discussionmentioning

confidence: 99%

A Curious Case of Primary Gastric Mucosal Melanoma

Sohail,

Samar,

Qureshi

et al. 2024

Korean J Gastroenterol

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Surgical resection and overall survival in cT4b sinonasal non‐squamous cell carcinoma

Patel,

Haleem,

Revercomb

et al. 2024

Laryngoscope Investig Oto

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ObjectiveSurgical resection is associated with higher overall survival (OS) than definitive radiotherapy (RT) or chemoradiotherapy (CRT) in cT4b sinonasal squamous cell carcinoma (SCC). Our study investigates the survival benefit of surgical resection in cT4b sinonasal non‐SCC.MethodsThe 2004 to 2019 National Cancer Database was queried for patients with cT4b sinonasal non‐SCC undergoing definitive treatment with (1) surgical resection + additional therapy (RT, chemotherapy, or both), (2) RT alone, or (3) CRT. Surgical resection + additional therapy and definitive RT/CRT were compared with Kaplan–Meier and multivariable Cox regression models.ResultsOf 629 patients satisfying inclusion criteria, 513 (81.6%) underwent surgical resection + additional therapy and 116 (18.4%) underwent definitive RT/CRT. The most frequent histologic types were undifferentiated carcinoma (23.7%), adenoid cystic carcinoma (22.6%), and adenocarcinoma (20.7%). Few patients presented with clinical nodal metastasis (15.7%). There were 4 (0.8%) mortalities within 90 days of surgical resection. Patients undergoing surgical resection with positive surgical margins had higher 5‐year OS than those undergoing definitive RT/CRT (56.3% vs. 39.4%, p = .039) and similar 5‐year OS as those with negative margins (56.3% vs. 63.9%, p = .059). Patients undergoing neoadjuvant chemotherapy had similar 5‐year OS as those undergoing definitive RT/CRT (60.9% vs. 39.5%, p = .053). Age at diagnosis, tumor diameter, and surgical resection + additional therapy (aHR 0.64, 95% CI 0.45–0.91) were associated with OS (p < .05).ConclusionSurgical resection + additional therapy was associated with higher OS than definitive RT/CRT in cT4b sinonasal non‐SCC. Surgical resection may benefit select patient with cT4b sinonasal non‐SCC.Level of Evidence4.

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Mucosal Melanoma of the Oral Cavity: What is the Role of Elective Neck Dissection?

Cited by 2 publications

References 31 publications

A Curious Case of Primary Gastric Mucosal Melanoma

A Curious Case of Primary Gastric Mucosal Melanoma

Surgical resection and overall survival in cT4b sinonasal non‐squamous cell carcinoma

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