Mucosal signaling in the bladder

Chai, Toby C.; Russo, Andrea; Yu, Shan Ping; Lu, Ming

doi:10.1016/j.autneu.2015.08.009

Cited by 22 publications

(22 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These transmitters may regulate the activity of primary bladder afferent nerves, which are anatomically located in close proximity to the urothelium. 16 This suggests that, in addition to forming an effective barrier to urine, the bladder urothelium also plays an important role in the transduction of bladder sensory inputs. Although the mechanisms of urothelial sensory transduction are not fully understood, several molecules appear to be involved in this process and have received a great deal of attention as potential therapeutic targets for bladder functional disorders, including IC, PBS, and OAB.…”

Section: The Role Of the Bladder Urotheliummentioning

confidence: 99%

Urothelial ATP signaling: what is its role in bladder sensation?

Takezawa

Kondo

Nonomura

et al. 2016

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

Section: The Role Of the Bladder Urotheliummentioning

confidence: 99%

Urothelial ATP signaling: what is its role in bladder sensation?

Takezawa

Kondo

Nonomura

et al. 2016

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

“…This research has yielded significant insight into the function of the detrusor muscle and valuable information concerning the sensory role of the urotheium [19,20] and various urothelial receptors [21]. Each of these prior studies has provided additional insight into the understanding of a clinically relevant urinary condition.…”

Section: Introductionmentioning

confidence: 99%

The urinary microbiota: a paradigm shift for bladder disorders?

Brubaker¹,

Wolfe

2016

Current Opinion in Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

Purpose of Review A resident microbial community (the female urinary microbiota, FUM) exists within the female bladder of many adult women. Information about the FUM is likely to modify the diagnosis, prevention and treatment of adult women with urinary disorders. This review highlights key findings from recent literature relevant to adult, non-pregnant women. Recent Findings Similar to other human microbial communities, the FUM varies in its characteristics, including organism diversity and predominant organism identity. Recent literature reveals previously undetected organisms and community characteristics that appear associated with certain urinary symptoms, including urinary tract infection and urgency urinary incontinence. The role of individual organisms may range from beneficial to pathogenic, and may vary based on an individual’s FUM characteristics. The simple dichotomy of “infected” or “sterile” no longer sufficiently captures the microbiological complexity of the female bladder. Summary Deeper understanding of the FUM should yield better methods to restore the microbiota to a healthy state, providing symptom relief. Opportunities to modify the FUM without antibiotic use are exciting possibilities for future research; stand-alone antibiotic use may be re-evaluated to improve treatment precision. Long-standing nomenclature for conditions such as asymptomatic bacteriuria and urinary tract infection will likely require modification.

show abstract

“…acting as an efficient barrier against urine as well as its accumulation, storage, and controlled release [32]. This process is being coordinated by the afferent and efferent neuronal pathways that transfer the sensory signals towards the central nervous system and feedback the response back to the bladder tissue, causing coordinated detrusor muscle contraction and voiding [33,34]. …”

Section: Bladder Anatomymentioning

confidence: 99%

Stem Cells in Functional Bladder Engineering

Smolar

Salemi

Horst

et al. 2016

Transfus Med Hemother

View full text Add to dashboard Cite

Conditions impairing bladder function in children and adults, such as myelomeningocele, posterior urethral valves, bladder exstrophy or spinal cord injury, often need urinary diversion or augmentation cystoplasty as when untreated they may cause severe bladder dysfunction and kidney failure. Currently, the gold standard therapy of end-stage bladder disease refractory to conservative management is enterocystoplasty, a surgical enlargement of the bladder with intestinal tissue. Despite providing functional improvement, enterocystoplasty is associated with significant long-term complications, such as recurrent urinary tract infections, metabolic abnormalities, stone formation, and malignancies. Therefore, there is a strong clinical need for alternative therapies for these reconstructive procedures, of which stem cell-based tissue engineering (TE) is considered to be the most promising future strategy. This review is focused on the recent progress in bladder stem cell research and therapy and the challenges that remain for the development of a functional bladder wall.

show abstract

Mucosal signaling in the bladder

Cited by 22 publications

References 67 publications

Urothelial ATP signaling: what is its role in bladder sensation?

Urothelial ATP signaling: what is its role in bladder sensation?

The urinary microbiota: a paradigm shift for bladder disorders?

Stem Cells in Functional Bladder Engineering

Contact Info

Product

Resources

About