Mueller Polarimetry of Brain Tissues

Novikova, Tatiana; Pierangelo, Angelo; Schucht, Philippe; Meglinski, Igor; Rodríguez-Núñez, Omar; Lee, Hee Ryung

doi:10.1007/978-3-031-04741-1_8

Cited by 8 publications

(5 citation statements)

References 68 publications

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“…The maps of the azimuth calculated with either Lu-Chipman decomposition (Fig. 1c) or Eqs (2)(3)(4)(5) demonstrate the compelling similarity. The drop in values of linear retardance in the central zone of the specimen (see Figs 1(b,c)) is highly likely related to either presence of underlying crossing fiber tracts or out-of-plane orientation of the fiber tracts.…”

Section: Resultsmentioning

confidence: 79%

“…The complete Mueller polarimetry represents a non-contact optical modality that is widely used in both clinical and pre-clinical studies of biological tissues. 1,2 However, the utility of polarimetric information acquired via each of 16 measurement channels is difficult to assess because of non-linear data compression algorithms of the complete MMs that are commonly used for the meaningful physical interpretation of tissue optical properties, namely, its diattenuation, retardance and depolarization. Several studies have reported the results on using the reduced number of MM elements for the analysis and diagnosis of tissue.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Partial Mueller polarimetry for the complete optical diagnosis of biological tissue

Novikova,

Ramella-Roman,

Felger

et al. 2023

Emerging Technologies for Cell and Tissue Characterization II

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Imaging Mueller polarimetry has already proved its potential for biomedical applications. However, tissue characterization utilizing all 16 elements of the Mueller matrix (MM) is not straightforward and requires data postprocessing decomposition algorithms. We developed the theoretical framework and performed the experimental studies on extracting the polarimetric parameters of phantoms and biological tissue while using only part of MM elements and validating them against the results of Lu-Chipman decomposition of corresponding complete MMs. Our findings open an avenue for developing simple and compact polarimetric systems operating at video rates that can be translated to clinics for real-time tissue diagnosis and monitoring.

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Section: Resultsmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Partial Mueller polarimetry for the complete optical diagnosis of biological tissue

Novikova,

Ramella-Roman,

Felger

et al. 2023

Emerging Technologies for Cell and Tissue Characterization II

View full text Add to dashboard Cite

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“…The group recently launched a multiyear, in-depth clinical project, which has been awarded a Swiss National Science Foundation Sinergia grant 205904. After 3 years of the HORAO conference, we have already published a series of promising preclinical results [ 49 - 53 ].…”

Section: Resultsmentioning

confidence: 99%

Exploring Novel Innovation Strategies to Close a Technology Gap in Neurosurgery: HORAO Crowdsourcing Campaign

Schucht¹,

Mathis²,

Murek³

et al. 2023

J Med Internet Res

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Background Scientific research is typically performed by expert individuals or groups who investigate potential solutions in a sequential manner. Given the current worldwide exponential increase in technical innovations, potential solutions for any new problem might already exist, even though they were developed to solve a different problem. Therefore, in crowdsourcing ideation, a research question is explained to a much larger group of individuals beyond the specialist community to obtain a multitude of diverse, outside-the-box solutions. These are then assessed in parallel by a group of experts for their capacity to solve the new problem. The 2 key problems in brain tumor surgery are the difficulty of discerning the exact border between a tumor and the surrounding brain, and the difficulty of identifying the function of a specific area of the brain. Both problems could be solved by a method that visualizes the highly organized fiber tracts within the brain; the absence of fibers would reveal the tumor, whereas the spatial orientation of the tracts would reveal the area’s function. To raise awareness about our challenge of developing a means of intraoperative, real-time, noninvasive identification of fiber tracts and tumor borders to improve neurosurgical oncology, we turned to the crowd with a crowdsourcing ideation challenge. Objective Our objective was to evaluate the feasibility of a crowdsourcing ideation campaign for finding novel solutions to challenges in neuroscience. The purpose of this paper is to introduce our chosen crowdsourcing method and discuss it in the context of the current literature. Methods We ran a prize-based crowdsourcing ideation competition called HORAO on the commercial platform HeroX. Prize money previously collected through a crowdfunding campaign was offered as an incentive. Using a multistage approach, an expert jury first selected promising technical solutions based on broad, predefined criteria, coached the respective solvers in the second stage, and finally selected the winners in a conference setting. We performed a postchallenge web-based survey among the solvers crowd to find out about their backgrounds and demographics. Results Our web-based campaign reached more than 20,000 people (views). We received 45 proposals from 32 individuals and 7 teams, working in 26 countries on 4 continents. The postchallenge survey revealed that most of the submissions came from single solvers or teams working in engineering or the natural sciences, with additional submissions from other nonmedical fields. We engaged in further exchanges with 3 out of the 5 finalists and finally initiated a successful scientific collaboration with the winner of the challenge. Conclusions This open innovation competition is the first of its kind in medical technology research. A prize-based crowdsourcing ideation campaign is a promising strategy for raising awareness about a specific problem, finding innovative solutions, and establishing new scientific collaborations beyond strictly disciplinary domains.

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Section: Outcomementioning

confidence: 99%

Exploring Novel Innovation Strategies to Close a Technology Gap in Neurosurgery: HORAO Crowdsourcing Campaign (Preprint)

Schucht¹,

Mathis²,

Murek³

et al. 2022

Preprint

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BACKGROUND With the current exponential increase in technical innovations worldwide, potential solutions for any new problem might already exist, despite having been developed to solve a different problem. We reached out to the crowd to raise awareness of our challenge of developing intraoperative, real-time identification of fiber tracts and tumor borders to improve neurosurgical oncology. OBJECTIVE Our objective was to evaluate the feasibility of crowdsourcing campaigns for raising awareness and finding out-of-the-box solutions for challenges in neuroscience. METHODS We ran a prize-based crowdsourcing competition on the commercial platform HeroX offering prize money previously collected through a crowdfunding campaign. In a multi-stage approach, we selected promising technical solutions based on broad, predefined criteria. RESULTS Our online campaign attracted more than 20,000 views, and we received 45 proposals from 32 individuals and 7 teams. These solvers, who were working in various fields, came from 26 countries on 4 continents. Further exchanges with 3 of the 5 finalists ensued, and a successful scientific collaboration was initiated with the winner of the challenge. CONCLUSIONS Prize-based crowdsourcing campaigns are a promising strategy for raising awareness, finding innovative solutions, and establishing new scientific collaborations in neuroscience. CLINICALTRIAL N/A

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Mueller Polarimetry of Brain Tissues

Cited by 8 publications

References 68 publications

Partial Mueller polarimetry for the complete optical diagnosis of biological tissue

Partial Mueller polarimetry for the complete optical diagnosis of biological tissue

Exploring Novel Innovation Strategies to Close a Technology Gap in Neurosurgery: HORAO Crowdsourcing Campaign

Exploring Novel Innovation Strategies to Close a Technology Gap in Neurosurgery: HORAO Crowdsourcing Campaign (Preprint)

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