Mukaiyama aldol reaction: an effective asymmetric approach to access chiral natural products and their derivatives/analogues

Abstract

Mukaiyama aldol reaction results in the highly enantioselective and diastereoselective synthesis of β-hydroxy carbonyls. Here, total syntheses of some natural products via this reaction as a key step have been presented.

Manganese/Enzyme Sequential Catalytic Pathway for the Production of Optically Active γ-Functionalized Alcohols

“…Among them, the synthesis of γ-functionalized alcohols via the formation of C–C bonds is an appealing method. Specifically, the use of chiral auxiliaries, enzyme catalysts, organocatalysis, or chiral metal catalysts to achieve asymmetric aldol reactions is widely recognized as the most common strategy for the synthesis of chiral γ-functionalized alcohols (Scheme A). Several noteworthy methods for C–O bond formation based on functional group-oriented strategies have been reported as well (Scheme B).…”