Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line

Chen, Pei‐Ni; Chu, Shu‐Chen; Chiou, Hui‐Ling; Kuo, Wu‐Hsien; Chiang, Chui-Liang; Hsieh, Yih‐Shou

doi:10.1016/j.canlet.2005.04.033

Cited by 377 publications

(236 citation statements)

References 35 publications

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“…Antioxidant activity was Different superscripts in each column indicate the significant differences in the mean at P < 0.05 Table 3 Different superscripts in each column indicate the significant differences in the mean at P < 0.05 the highest in the cultivar Zolushka with the value of 10.17 g of AAE/kg FM. In other fruit species, including apples (Huber, Rupasinghe 2009), small berries, and stone fruit (Chen et al 2006), the values of antioxidant activity are mostly much lower. For example, in cherries there are values of up to 0.9 g of AAE/kg FM (Usenik et al 2008) and in plums the values can reach up to 6 g of AAE/kg FM (Rop et al 2009).…”

Section: Resultsmentioning

confidence: 99%

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Antioxidant and radical oxygen species scavenging activities of 12 cultivars of blue honeysuckle fruit

Rop¹,

Řezníček²,

Mlček³

et al. 2011

Hortic. Sci.

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Rop O., Řezníček V., Mlček J., Juríková T., Balík J., Sochor J., Kramářová D., 2011. Antioxidant and radical oxygen species scavenging activities of 12 cultivars of blue honeysuckle fruit. Hort. Sci. (Prague), 38: 63-70.The fruit of blue honeysuckle (Lonicera caerulea L. var. kamtchatica (Sevast.) Pojark.) belongs to the fruit of great value because of itsunique chemical composition. The aim of our measurement of this fruit species was to select the cultivars which could be the most suitable food supplement in relation to strengthening human immunity system. The comparison of the fruit of 12 cultivars was made. The highest contents of polyphenolic substances were recorded in the cultivar Zolushka with the value of 9.03 g of gallic acid/kg fresh mass. In particular cultivars the DPPH (2,2-diphenyl-1-picrylhydrazyl) test was performed to determine antioxidant activity which ranged from 6.59-10.17 g of ascorbic acid equivalent/kg fresh mass. For comparison, scavenging activity of reactive oxygen species (superoxide anion, hydroxyl radical, and nitric oxide) was determined by using a 25% methanolic extract of fruit of particular cultivars. Antioxidant potential was also assessed using the rat liver slice model. The highest values of scavenging activity were found in the cultivars Zolushka, Goluboe vreteno, and Gerda. The cultivars Zolushka, Goluboe vreteno, and Gerda had also high values of flavonoids. The presented results may be used when popularizing this fruit species and also when studying the properties of new food and genetic resources.

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Section: Resultsmentioning

confidence: 99%

“…Flavonoids are known to retain free radical scavenging activity by forming complexes with metal ions. Potent chelating activities with metal ions might come from abundant contents of kaempferol and quercetin (Chen et al 2006). Generally, flavonoids identify possessed antioxidant activity including scavenging free radicals (Crozier et al 2009).…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and radical oxygen species scavenging activities of 12 cultivars of blue honeysuckle fruit

Rop¹,

Řezníček²,

Mlček³

et al. 2011

Hortic. Sci.

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“…In particular, uPA has been implicated in remodeling of the ECM, enhancing both cell proliferation and migration, and modulating cell adhesion [Choong and Nadesapillai, 2003;Reuning et al, 2003]. Recently, it was suggested that the inhibitory effects of two mulberry anthocyanins, cyanidin 3-glucoside and cyanidin 3-rutinoside, on the invasion and motility of A549 human lung carcinoma cells were related to the inhibition of uPA and MMP-2 activities and to the induction of the expression of PAI and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) [Chen et al, 2006]. Furthermore, it was demonstrated that Dp inhibited the MMP-2 and MMP-9 activities of human fibrosarcoma HT-1080 cells, an effect that may be responsible, at least in part, for the inhibition of tumor cell invasiveness by the molecule [Nagase et al, 1998].…”

Section: Discussionmentioning

confidence: 99%

Anthocyanidins inhibit migration of glioblastoma cells: Structure‐activity relationship and involvement of the plasminolytic system

Lamy

Lafleur

Bédard

et al. 2006

J of Cellular Biochemistry

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Complete resection of malignant glioblastomas is usually impossible because of diffuse and widespread invasion of tumor cells, and complementary approaches need to be developed in order to improve the efficacy of current treatments. Consumption of fruits and berries has been associated with decreased risk of developing cancer and there is great interest in the use of molecules from dietary origin to improve anticancer therapies. In this work, we report that the aglycons of the most abundant anthocyanins in fruits, cyanidin (Cy), delphinidin (Dp), and petunidin (Pt), act as potent inhibitors of glioblastoma cell migration. Dp clearly exhibited the highest inhibitory potency, this effect being related to the ortho-dihydroxyphenyl structure on the B-ring and the presence of a free hydroxyl group at position 3. Dp decreases the expression of both urokinase-type plasminogen activator receptor (uPAR) and the low-density lipoprotein receptor-related protein (LRP), acting at the transcriptional levels. In addition, Dp upregulated urokinase-type plasminogen activator (uPA) and downregulated the plasminogen activator inhibitor-1 (PAI-1) but decreased, in a concentration-dependent manner, the uPA-dependent conversion of plasminogen to plasmin, indicating that the upregulation of uPA observed with these compounds was not associated with induction of the plasminolytic activity. Overall, these results demonstrate that Dp, Pt, and Cy affect plasminogen activation, thus leading to the inhibition of glioblastoma cell migration and therefore they may be helpful for the development of new strategies for cancer prevention and therapy.

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“…Anthocyanins are a group of natural flavonoids responsible for the red, violet and blue colours of berries and fruits (Nyman & Kumpulainen 2001;Tian et al 2006). As the common antioxidants, anthocyanins may have health benefits in the prevention of chronic and degenerative diseases including heart diseases and cancer (Wu & Prior 2005;Chen et al 2006). In recent years, as increasing attention has been paid to health benefits of natural anthocyanins, the substitution of synthetic pigments by natural anthocyanins for has already become a social trend.…”

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confidence: 99%

“…Mulberry fruit has plentiful anthocyanins. These occur as cyanidin-3-glucoside and cyanidin-3-rutinoside (Suh et al 2004;Chen et al 2006;Lin & Tang 2007). As a traditional Chinese edible fruit, mulberry fruit is used effectively in folk medicine to treat fever, protect the liver from damage, strengthen the joints, facilitate the discharge of urine, and lower the blood pressure (Yang 1998;Jia et al 1999;Chen et al 2005Chen et al , 2006Bae & Suh 2007).…”

mentioning

confidence: 99%

Separation and character analysis of anthocyanins from mulberry (Morus alba L.) pomace

Zhang¹,

He²,

QiuHong³

et al. 2011

Czech J. Food Sci.

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Zhang W., He J., Pan Q., Han F., Duan C. (2011): Separation and character analysis of anthocyanins from mulberry (Morus alba L.) pomace. Czech J. Food Sci., 29: 268-276.Mulberry pomace, as a by-product of juice and wine making, was investigated as a potential source of natural anthocyanins. The results showed that anthocyanin contents in mulberry pomace from two varieties were above 250 mg/100 g, that is 74%-79% of that in mulberry whole fruit. Thus, mulberry pomace could be a potential anthocyanins source. The anthocyanins in mulberry pomace had an attractive red colour with the chroma at 5.0 and hue angle at 6.8. Five anthocyanins were identified in mulberry pomace, cyanidin-3-glucoside and cyanidin-3-rutinoside being the major anthocyanins. The method of the separation of the two anthocyanins was studied showing that both anthocyanins with purities above 98% could be well separated on Sephadex LH-20 by eluting with 10% ethanol containing 1% of acetic acid after purification with AB-8 macroporous resin. The recovery of the complete process of both anthocyanins was 57.4%. Cyanidin-3-glucoside and cyanidin-3-rutinoside had more attractive colours and strong antioxidant activities and could be used as potential food colourants and antioxidants.

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Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line

Cited by 377 publications

References 35 publications

Antioxidant and radical oxygen species scavenging activities of 12 cultivars of blue honeysuckle fruit

Antioxidant and radical oxygen species scavenging activities of 12 cultivars of blue honeysuckle fruit

Anthocyanidins inhibit migration of glioblastoma cells: Structure‐activity relationship and involvement of the plasminolytic system

Separation and character analysis of anthocyanins from mulberry (Morus alba L.) pomace

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