Mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (STZ)-induced diabetic rats fed high-fat diet

Evaluation of a Standardized Extract from Morus alba against α‐Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double‐Blind Clinical Trial

“…In addition, in the acute toxicity evaluation, no toxicity was observed. M. alba extracts have been previously reported to have antihyperglycemic effect in STZ-induced diabetic rats [27] and in diet-induced obese mice [28] and to block inflammatory response in STZ-diabetic mice model [29] and in STZ-induced diabetic rats fed high-fat diet [30]. Among them, Jeszka-Skowron et al have reported that DNJ may suggest additional roles in the gut to reduce or inhibit intestinal glucose digestion and absorption [30].…”

Effects of flavonoids-rich Chinese bayberry (Myrica rubra Sieb. et Zucc.) pulp extracts on glucose consumption in human HepG2 cells

“…Litchi pulp extracts with high (-)-epicatechin content resulted in a significant glucose consumption activity (Lv et al, 2014). Mulberry leaf extracts exerted antidiabetic effects by increasing plasma insulin and decreasing blood glucose in diabetic rats fed with high fat diet (Jeszka-Skowron et al, 2014). Anthocyanin-rich bilberry extract significantly reduced the blood glucose and enhanced insulin sensitivity in type 2 diabetic mice (Takikawa, Inoue, Horio, & Tsuda, 2010).…”

Mulberry polyphenols induce cell cycle arrest of vascular smooth muscle cells by inducing NO production and activating AMPK and p53

“…Similarly, mulberry leaves have also shown promising biological effects (Jeszka-Skowron et al, 2014;Wu et al, 2013). Previous studies have shown the anti-hyperlipidemic, anticancer, liver-protecting, anti-inflammatory, and anti-obesity effects of mulberry water extracts (Hsu et al, 2012;Jeong, Jang, Kim, Kwon, & Kim, 2010;Ou et al, 2011Ou et al, , 2013Park, Lee, & Kim, 2013;Peng et al, 2011) as well as their ability to inhibit the development of atherosclerosis in cholesterol-fed rabbits (Chen et al, 2005).…”